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PHKB

Official Full Name

phosphorylase kinase, beta
Overview

Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, encoded by this gene, which is a member of the phosphorylase b kinase regulatory subunit family. The gamma subunit also includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9B, also known as phosphorylase kinase deficiency of liver and muscle. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. Two pseudogenes have been found on chromosomes 14 and 20, respectively.
Synonyms

PHKB; phosphorylase kinase, beta; phosphorylase b kinase regulatory subunit beta; DKFZp781E15103; FLJ41698; Phosphorylase kinase B; Phosphorylase kinase beta polypeptide; Phosphorylase kinase beta subunit; OTTHUMP00000164134; phosphorylase kinase beta-subunit; phosphorylase kinase subunit beta;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rhesus Macaque

Source

HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
Myc
DDK
MYC

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	PHKB-3423H	Recombinant Human PHKB Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK	Inquiry
Mouse	PHKB-12739M	Recombinant Mouse PHKB Protein	Mammalian Cell	His	Inquiry
Mouse	Phkb-200M	Recombinant Mouse Phkb Protein, MYC/DDK-tagged	HEK293T	MYC/DDK	Inquiry
Mouse	PHKB-6699M	Recombinant Mouse PHKB Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	PHKB-6699M-B	Recombinant Mouse PHKB Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rhesus Macaque	PHKB-3411R	Recombinant Rhesus monkey PHKB Protein, His-tagged	Mammalian Cell	His	Inquiry
Rhesus Macaque	PHKB-3229R	Recombinant Rhesus Macaque PHKB Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rhesus Macaque	PHKB-3229R-B	Recombinant Rhesus Macaque PHKB Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Chicken	PHKB-1757C	Recombinant Chicken PHKB	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
PHKB Related Articles

PHKB involved in several pathways and played different roles in them. We selected most pathways PHKB participated on our site, such as Calcium signaling pathway, Insulin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PHKB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Calcium signaling pathway	ERBB3;RYR1;SLC8A3;PPP3R1B;GRIN2A;CALML3;CACNA1B;PLCG1;MYLK
Insulin signaling pathway	SOCS3;INS;FBP1;PRKAR2AB;FOXO1B;PRKAA2;CALM;PRKCI;TSC1A

PHKB has several biochemical functions, for example, calmodulin binding, catalytic activity, contributes_to phosphorylase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PHKB itself. We selected most functions PHKB had, and list some proteins which have the same functions with PHKB. You can find most of the proteins on our site.

Function	Related Protein
calmodulin binding	KCNN1B;DDX5;MYH10;RYR1;GAP43;CAMK2D;PLCB3;RGS16;CAMK1D
catalytic activity	OLFM4;PFKMA;ALAD;ACSL1;SLC3A2A;HADHAB;CKMT2A;TM9SF1;PKM
contributes_to phosphorylase kinase activity	PHKA1;PHKB
phosphorylase kinase activity	PHKG1B;PHKG2;PHKG1;PHKG1A;PHKB;PHKA2

PHKB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PHKB here. Most of them are supplied by our site. Hope this information will be useful for your research of PHKB.

CALM1

de Luna, N; Brull, A; et al. PYGM expression analysis in white blood cells: A complementary tool for diagnosing McArdle disease?. NEUROMUSCULAR DISORDERS 24:1079-1086(2014).

Ammendola, M; Sacco, R; et al. Correlation between Serum Tryptase, Mast Cells Positive to Tryptase and Microvascular Density in Colo-Rectal Cancer Patients: Possible Biological-Clinical Significance. PLOS ONE 9:-(2014).