rap1b
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  • Official Full Name
  • RAP1B, member of RAS oncogene family
  • Background
  • Rap1 and Rap2 belong to the Ras subfamily of small GTPases and are activated by a wide variety of stimuli through integrins, receptor tyrosine kinases (RTKs), G-protein coupled receptors (GPCR), death domain associated receptors (DD-R) and ion channels (1
  • Synonyms
  • RAP1B; RAP1B, member of RAS oncogene family; ras-related protein Rap-1b; DKFZp586H0723; K REV; RAL1B; RAS-related protein RAP1B; small GTP binding protein; GTP-binding protein smg p21B; Ras family small GTP binding protein RAP1B; K-REV; FLJ18601
Cat.#:RAP1B-3469HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAP1B, His-tagged
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Cat.#:RAP1B-1127HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAP1B, Member Of RAS Oncogene Family
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Cat.#:RAP1B-2177HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAP1B, GST-tagged
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Cat.#:RAP1B-4924RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RAP1B Protein
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Cat.#:RAP1B-844CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus RAP1B Protein, His-tagged
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Cat.#:RAP1B-3785RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey RAP1B Protein, His-tagged
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Cat.#:RAP1B-1777CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RAP1B
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Cat.#:RAP1B-9939ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RAP1B
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Cat.#:RAP1B-2528HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RAP1B 293 Cell Lysate
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Involved Pathway

RAP1B involved in several pathways and played different roles in them. We selected most pathways RAP1B participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAP1B were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
TGFBR1; MAP2K2; MAPK12; MAPK14A; PRKACA; CACNB2A; MAP3K2; FASLG; CACNA1D; RAP1AA
Ras signaling pathway
NFKB1; PAK3; PLA1A; GNG8; PRKCA; ANGPT2; PLA2G2D; MET; GRIN2A; PDGFRA
Rap signaling pathway
SIPA1L2; SKAP1; PLCB3; RAC2; MAP2K1; FGF3; CALM1; PDGFD; PRKD2; FGF19
cAMP signaling pathway
RAC2; PIK3R5; PDE4B; CAMK2B; NPY; PIK3R1; AKT1; ATP1A1; GRIA4; GRIN2D
Chemokine signaling pathway
PXN; Ccl12; CXCL5; CCL4L2; PRKACA; GNG11; GNG5; GM1987; CCL16; CCL13
Focal adhesion
COL6A5; MAPK8A; COL27A1B; HRASB; PARVA; CCND2A; COL5A1; PIK3R3B; CCND1; VCLA
Platelet activation
PPP1R12A; MYL12A; MAPK3; VASP; ARHGEF1; COL27A1; PIK3R1; MAPK1; PIK3R5; FGG
Leukocyte transendothelial migration
MMP9; CLDN9; RHOH; CLDN7; CLDN6; ARHGAP35; CLDN16; PIK3CG; CXCR4; BCAR1
Long-term potentiation
RPS6KA2; CALM4; MAPK3; GRIN1; MAP2K2; CAMK4; CAMK2B; PPP3CA; GRIN2B; PLCB1
Neurotrophin signaling pathway
GAB1; PSEN1; PIK3CA; NGF; MAPK7; PIK3R2; PDPK1; CALM1; MAP3K1; NFKB1
Pancreatic secretion
RAB27B; RAB8A; PRSS2; PRSS3; RAB3D; RYR2; ATP1A1; ATP1B1; ATP2A2; PLA2G3
Renal cell carcinoma
RAP1B; EGLN1; PIK3CD; MAP2K2; ETS1; SOS1; TCEB2; PAK6; PIK3CB; PAK1

Protein Function

RAP1B has several biochemical functions, for example, GDP binding, GTP binding, GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAP1B itself. We selected most functions RAP1B had, and list some proteins which have the same functions with RAP1B. You can find most of the proteins on our site.
Function
Related Protein
Function GDP binding
Related Protein SRP54B; RAB7L1; RAB9A; RRAGC; GNAI1; PRPS2; ARF1; RAB40C; RAB27B; GEM
Function GTP binding
Related Protein IRGF1; GTPBP4; GTPBP5; MOCS1; MXA; TUBB4B; RAB9B; NOLC1; RAB36; EFTUD1
Function GTPase activity
Related Protein RALBB; DNM1B; GNL3; DNM1; RAB5AA; ARF4; DNM2A; RAB40B; TUBB2B; TBCC
Function protein binding
Related Protein CCDC92; GAPDHS; TCP1; KDM5B; DUSP19; MAPK11; CLDN18; ZNF230; FATE1; KCNE3
Function protein complex binding
Related Protein CDK2; MYC; ST13; CDKN1A; ANKRD32; PLK2; PFKP; DRD1; ADM2; SREBF1

Interacting Protein

RAP1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAP1B here. Most of them are supplied by our site. Hope this information will be useful for your research of RAP1B.
RALGDS; RASSF5; VCAM1; UBC; RAP1GAP; RAPGEF3; MCC; PAK2; MAP3K14; SMURF2; RGL2

RAP1B Related Articles

Sayyah, J; Bartakova, A; et al. The Ras-related Protein, Rap1A, Mediates Thrombin-stimulated, Integrin-dependent Glioblastoma Cell Proliferation and Tumor Growth. JOURNAL OF BIOLOGICAL CHEMISTRY 289:17689-17698(2014).
Subramanian, H; Zahedi, RP; et al. Phosphorylation of CalDAG-GEFI by protein kinase A prevents Rap1b activation. JOURNAL OF THROMBOSIS AND HAEMOSTASIS 11:1574-1582(2013).