rap1b
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  • Official Full Name
  • RAP1B, member of RAS oncogene family
  • Background
  • Rap1 and Rap2 belong to the Ras subfamily of small GTPases and are activated by a wide variety of stimuli through integrins, receptor tyrosine kinases (RTKs), G-protein coupled receptors (GPCR), death domain associated receptors (DD-R) and ion channels (1
  • Synonyms
  • RAP1B; RAP1B, member of RAS oncogene family; ras-related protein Rap-1b; DKFZp586H0723; K REV; RAL1B; RAS-related protein RAP1B; small GTP binding protein; GTP-binding protein smg p21B; Ras family small GTP binding protein RAP1B; K-REV; FLJ18601
Cat.#:RAP1B-3469HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAP1B, His-tagged
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Cat.#:RAP1B-1127HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAP1B, Member Of RAS Oncogene Family
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Cat.#:RAP1B-2177HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAP1B, GST-tagged
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Cat.#:RAP1B-4924RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RAP1B Protein
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Cat.#:RAP1B-844CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus RAP1B Protein, His-tagged
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Cat.#:RAP1B-3785RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey RAP1B Protein, His-tagged
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Cat.#:RAP1B-1777CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RAP1B
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Cat.#:RAP1B-9939ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RAP1B
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Cat.#:RAP1B-2528HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RAP1B 293 Cell Lysate
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Involved Pathway

RAP1B involved in several pathways and played different roles in them. We selected most pathways RAP1B participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAP1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
MAPK8A; ECSIT; FLNC; HRASA; CACNA2D4; NTF3; HSPA6; PPM1NB; RAF1; PLA2G4C
Ras signaling pathway
RALB; IKBKB; FGFR4; PLA2G5; RRAS; VEGFB; GNG12; PRKCA; Pdgfa&Pdgfb; SHC3
Rap signaling pathway
MAPK11; PLCB1; AKT2; FGFR2; BCAR1; MAP2K3; FGF6; GNAS; PIK3R3; PDGFRA
cAMP signaling pathway
GNAI2; PPARA; CAMK4; GRIA1; PIK3CB; PLN; HTR4; PIK3R2; RAC2; GRIN2D
Chemokine signaling pathway
SHC1; Ccl12; CXCL5; PIK3R3; GSK3B; PIK3R1; GNGT1; MAPK3; CXCR6; ITK
Focal adhesion
ITGA6; MAPK10; ITGB6; COL6A4; PIK3R5; PRKCG; HGF; ACTN1; TNXB; LAMA5
Platelet activation
P2RX1; GNAI1; GP5; PLA2G4F; PRKG2; PIK3CB; GNAI3; VASP; SRC; GNAQ
Leukocyte transendothelial migration
CLDN5; CLDN8; NCF1; NOX3; ACTN2; MYL2; VCL; MLLT4; PIK3CG; MYL9
Long-term potentiation
PRKACG; PPP3R2; CAMK2D; GRIN2B; PRKACA; GRIA1; ARAF; CAMK2G; PPP1CC; PRKCB
Neurotrophin signaling pathway
PIK3CB; MAP3K1; SHC4; MAGED1; MAP2K2; KIDINS220; ZFP110; ABL1; PLCG1; YWHAE
Pancreatic secretion
CPA1; AMY2B; PNLIPRP1; CPB1; CA2; PLCB2; TRPC1; ATP1B4; ATP2B1; RAP1A
Renal cell carcinoma
HIF1A; PAK1; MAP2K2; EGLN1; NRAS; VEGFA; PIK3R5; SOS1; TCEB2; SLC2A1

Protein Function

RAP1B has several biochemical functions, for example, GDP binding, GTP binding, GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAP1B itself. We selected most functions RAP1B had, and list some proteins which have the same functions with RAP1B. You can find most of the proteins on our site.
Function
Related Protein
Function GDP binding
Related Protein RAB9B; EIF2B1; ARF1; RHOB; RAP2B; RAB5C; RAB4A; RAB8B; RAB17; RAB18
Function GTP binding
Related Protein RHEBL1; GNAI1; RAB22A; SEPT7A; ARHGAP5; RASL10A; ARL10; RAB5AB; RAB9A; RABL6
Function GTPase activity
Related Protein SAR1B; TUBB1; GNA13; RND3; GTPBP2; RAB27B; RAB17; RAB5B; SEPT4; RAB39A
Function protein binding
Related Protein TXNDC11; AKIP1; C19orf40; EFNB1; CCT2; POU2F3; EDC3; WBP11; FGFBP1; UPF3A
Function protein complex binding
Related Protein ABI2; KRAS; LCK; SLC27A5; KRIT1; ATM; LRRC16A; RIPK1; UQCRFS1; DLG4

Interacting Protein

RAP1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAP1B here. Most of them are supplied by our site. Hope this information will be useful for your research of RAP1B.
RALGDS; RASSF5; VCAM1; UBC; RAP1GAP; RAPGEF3; MCC; PAK2; MAP3K14; SMURF2; RGL2

RAP1B Related Articles

Sayyah, J; Bartakova, A; et al. The Ras-related Protein, Rap1A, Mediates Thrombin-stimulated, Integrin-dependent Glioblastoma Cell Proliferation and Tumor Growth. JOURNAL OF BIOLOGICAL CHEMISTRY 289:17689-17698(2014).
Subramanian, H; Zahedi, RP; et al. Phosphorylation of CalDAG-GEFI by protein kinase A prevents Rap1b activation. JOURNAL OF THROMBOSIS AND HAEMOSTASIS 11:1574-1582(2013).