rapgef4
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  • Official Full Name
  • Rap guanine nucleotide exchange factor (GEF) 4
  • Background
  • EPAC1 and EPAC2 (exchange proteins activated by cyclic AMP) are guanine nucleotide exchange factors (GEFs) that catalyze the exchange of GDP for GTP, activating Rap1 and Rap2 small GTPases. Rap activation by EPAC is cAMP-dependent and mediates cAMP signal
  • Synonyms
  • RAPGEF4; Rap guanine nucleotide exchange factor (GEF) 4; rap guanine nucleotide exchange factor 4; exchange protein directly activated by cAMP 2; cAMP GEFII; cAMP regulated guanine nucleotide exchange factor
Cat.#:RAPGEF4-2637HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Rap Guanine Nucleotide Exchange Factor (GEF) 4
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Cat.#:RAPGEF4-2182HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAPGEF4, His-tagged
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Cat.#:RAPGEF4-2520HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RAPGEF4 293 Cell Lysate
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Involved Pathway

RAPGEF4 involved in several pathways and played different roles in them. We selected most pathways RAPGEF4 participated on our site, such as Adaptive Immune System, Adrenergic signaling in cardiomyocytes, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAPGEF4 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
LRR1; RNF25; RNF14; CLEC2D; BLK; CLTA; BLMH; ASB14; KIFAP3; FRS2
Adrenergic signaling in cardiomyocytes
CACNA2D1A; PPP1CAB; ADCY8; SLC14A2; ATP2A2; CACNG8; MAPK14B; PIK3R5; AKT1; AKT3A
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
GNB5B; GCGB; GCGA; RAPGEF3; AKAP5; KCNB1; GNB5A; KCNS3A; KCNS3; KCNC2
Hemostasis
HBG1; RHOGA; ANGPT2A; IRF2; DOCK10; SERPINE2; KIF5A; DGKG; SIRPA; CABLES2
Immune System
TRIM17; FBXO44; NLRP4B; DEFA1; SIGIRR; IL1RN; KIF5A; KIF11; BTR09; PANX1A
Insulin secretion
FXYD2; ATP1B3; CREB5; CCKAR; KCNJ11; RAB3A; VAMP2; PDX1; PRKACA; PRKCG
Integration of energy metabolism
KCNJ11; ARL2; RAPGEF4; MARCKSA; RAPGEF3; KCNB1; ARL2BP; KCNC2; KCNS3A; GNB5A
Integrin alphaIIb beta3 signaling
RAPGEF3; LOC100514666; FN1B; ITGB3A; RAPGEF4

Protein Function

RAPGEF4 has several biochemical functions, for example, Ras GTPase binding, Ras guanyl-nucleotide exchange factor activity, cAMP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAPGEF4 itself. We selected most functions RAPGEF4 had, and list some proteins which have the same functions with RAPGEF4. You can find most of the proteins on our site.
Function
Related Protein
Function Ras GTPase binding
Related Protein PLCE1; SPHK2; RAP1GAP; RAPGEF4; CIB1; MLLT4; RASGRP3; RGL3; RAP1A; RIN1
Function Ras guanyl-nucleotide exchange factor activity
Related Protein ADRB1; SOS1; RASGEF1A; RASGEF1B; RAPGEF5; RAB3A; RASGRP4; RASGRP3; RAPGEF4; RGL2
Function cAMP binding
Related Protein CNGA2; CNMPD1; PDE4A; PDE2A; HCN2; PRKAR1B; BVES; PDE4D; PDE3A; PDE4B
Function guanyl-nucleotide exchange factor activity
Related Protein DENND5B; RASGRF2B; TBXAS1; KALRN; RINL; RIC8; SH2D3C; RANGRF; RASGEF1BA; ARHGEF1B
Function protein binding
Related Protein TMED9; KRT5; MATN4; MOB3C; STT3A; LRRC7; DFFA; CHMP4C; LZTS1; SPATA2

Interacting Protein

RAPGEF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAPGEF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAPGEF4.
C16orf45; ATXN1; SLC22A7; 3',5'-cyclic amp

RAPGEF4 Related Articles

Hwang, JY; Sim, X; et al. Genome-Wide Association Meta-analysis Identifies Novel Variants Associated With Fasting Plasma Glucose in East Asians. DIABETES 64:291-298(2015).
Vadnais, ML; Aghajanian, HK; et al. Signaling in Sperm: Toward a Molecular Understanding of the Acquisition of Sperm Motility in the Mouse Epididymis. BIOLOGY OF REPRODUCTION 89:-(2013).