RAPGEF4

  • Official Full Name

    Rap guanine nucleotide exchange factor (GEF) 4
  • Overview

    EPAC1 and EPAC2 (exchange proteins activated by cyclic AMP) are guanine nucleotide exchange factors (GEFs) that catalyze the exchange of GDP for GTP, activating Rap1 and Rap2 small GTPases. Rap activation by EPAC is cAMP-dependent and mediates cAMP signal
  • Synonyms

    RAPGEF4;Rap guanine nucleotide exchange factor (GEF) 4;rap guanine nucleotide exchange factor 4;exchange protein directly activated by cAMP 2;cAMP GEFII;cAMP regulated guanine nucleotide exchange factor
Cat.# Product name Source (Host) Species Tag Protein Length Price
RAPGEF4-2182H Recombinant Human RAPGEF4, His-tagged E.coli Human His C-term-300aa
RAPGEF4-2637H Recombinant Human Rap Guanine Nucleotide Exchange Factor (GEF) 4 E.coli Human Non
RAPGEF4-2520HCL Recombinant Human RAPGEF4 293 Cell Lysate HEK293 Human Non
Rapgef4-5378M Recombinant Mouse Rapgef4 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc

    Involved Pathway

    RAPGEF4 involved in several pathways and played different roles in them. We selected most pathways RAPGEF4 participated on our site, such as Adaptive Immune System,Adrenergic signaling in cardiomyocytes,Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAPGEF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Insulin secretion VAMP2,GCG,PRKCB,INS1,ADCYAP1,GNAQ,RIMS2,PLCB4,PRKCA,KCNMA1
    Adaptive Immune System KIF2A,NA,CD200R1,ARF1,AGO3,SIGLEC7,RNF144B,GAN,RNF41,SH2D1B
    Integrin alphaIIb beta3 signaling ITGB3A,LOC100514666,FN1B,RAPGEF3
    Hemostasis F9A,GATA6,GATA1A,CD177,DGKQ,KIF2B,KIF3C,CABLES1,MYB,KIFC1
    Adrenergic signaling in cardiomyocytes PPP2R5B,CACNA1D,CACNG2A,AKT2L,GNA15.4,FXYD2,PPP2R5EB,PLCB1,CACNG1A,ACTC1
    Immune System PAG1,MICA,RCA2.1,RIPK3,TRIM10,GAN,CFHL1,POLR3G,FAM49BA,KIF26A
    Integration of energy metabolism KCNJ11,KCNC2,MARCKSB,GNB5A,RAPGEF3,ARL2BP,KCNB1,ARL2,KCNS3,MARCKSA

    Protein Function

    RAPGEF4 has several biochemical functions, for example, Ras GTPase binding,Ras guanyl-nucleotide exchange factor activity,cAMP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAPGEF4 itself. We selected most functions RAPGEF4 had, and list some proteins which have the same functions with RAPGEF4. You can find most of the proteins on our site.

    Function Related Protein
    cAMP binding HCN2,PRKAR1B,PDE4A,CNGA2,PDE4D,HCN4,PDE4B,PDE11A,PDE2A,CNMPD1
    Ras GTPase binding SPHK2,RAP1A,MAPKAP1,RIN1,CIB1,SH3BP4,MAP2K1,RAPGEF6,MLLT4,RASGRP3
    protein binding CASC3,AHSA1,TMEM30A,MEI4,CEP120,PPFIA4,SNAP23,ADRB1,SLMAP,RPRD1A
    guanyl-nucleotide exchange factor activity SH2D3C,PLCE1,PREX1,FGD6,TRIO,DOCK7,ARHGEF4,P2RY12,ARHGEF7A,PTGIR
    Ras guanyl-nucleotide exchange factor activity ADRB1,RASGEF1B,RASGEF1BA,RAPGEF5,RASGRP1,RGL2,RASGRP3,RAB3A,KNDC1,RASGEF1BB

    Interacting Protein

    RAPGEF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAPGEF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAPGEF4.

    C16orf45;ATXN1;SLC22A7;3',5'-cyclic amp

    Resources

    References

    • Hwang, JY; Sim, X; et al. Genome-Wide Association Meta-analysis Identifies Novel Variants Associated With Fasting Plasma Glucose in East Asians. DIABETES 64:291-298(2015).
    • Vadnais, ML; Aghajanian, HK; et al. Signaling in Sperm: Toward a Molecular Understanding of the Acquisition of Sperm Motility in the Mouse Epididymis. BIOLOGY OF REPRODUCTION 89:-(2013).

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