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RAPGEF4

Official Full Name

Rap guanine nucleotide exchange factor (GEF) 4
Overview

EPAC1 and EPAC2 (exchange proteins activated by cyclic AMP) are guanine nucleotide exchange factors (GEFs) that catalyze the exchange of GDP for GTP, activating Rap1 and Rap2 small GTPases. Rap activation by EPAC is cAMP-dependent and mediates cAMP signal
Synonyms

RAPGEF4; Rap guanine nucleotide exchange factor (GEF) 4; rap guanine nucleotide exchange factor 4; exchange protein directly activated by cAMP 2; cAMP GEFII; cAMP regulated guanine nucleotide exchange factor;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	RAPGEF4-2182H	Recombinant Human RAPGEF4, His-tagged	E.coli	His	C-term-300aa	$319 / 25ug
Human	RAPGEF4-2637H	Recombinant Human Rap Guanine Nucleotide Exchange Factor (GEF) 4	E.coli	N/A		Inquiry
Human	RAPGEF4-2520HCL	Recombinant Human RAPGEF4 293 Cell Lysate	HEK293	N/A		Inquiry
Mouse	Rapgef4-5378M	Recombinant Mouse Rapgef4 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry

Involved Pathway
Protein Function
Interacting Protein
RAPGEF4 Related Articles

RAPGEF4 involved in several pathways and played different roles in them. We selected most pathways RAPGEF4 participated on our site, such as Adaptive Immune System, Adrenergic signaling in cardiomyocytes, Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAPGEF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Adaptive Immune System	IFI30;CTSE;IGLC2;DZIP3;RNF123;AGO1;PJA2;STIM1B;CD200R1
Adrenergic signaling in cardiomyocytes	TNNC1B;TPM4A;SCN4BA;ATP1B2A;ATP2B1A;TMEM8C;PPP1CB;ATF6B;TNNC1
Hemostasis	PROCA;KIF4A;NADL1.1;IGF2B;ZFPM1;SLC7A8A;CD84;HBE1;KIF4
Immune System	BTR06;KIF2C;HCST;IFI27;CD300E;DEFB106A;TRIM2;IRF2;PLD4
Insulin secretion	KCNN4;PRKACA;KCNMB2;INS1;KCNN3;ATP1A3;CAMK2D;ATP1B3;CREB5
Integration of energy metabolism	SYT5;ARL2BP;RAPGEF4;GNG13A;MARCKSB;MARCKSA;GNG13B;RAPGEF3;KCNS3A
Integrin alphaIIb beta3 signaling	RAPGEF4;LOC100514666;RAPGEF3;ITGB3A;FN1B

RAPGEF4 has several biochemical functions, for example, Ras GTPase binding, Ras guanyl-nucleotide exchange factor activity, cAMP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAPGEF4 itself. We selected most functions RAPGEF4 had, and list some proteins which have the same functions with RAPGEF4. You can find most of the proteins on our site.

Function	Related Protein
Ras GTPase binding	RAPGEF4;RAPGEF6;RGL3;PLCE1;CIB1;RASGRP3;RAP1GAP;MAP2K1;SH3BP4
Ras guanyl-nucleotide exchange factor activity	RASGRP4;RASGEF1BA;RAPGEF4;RASGEF1BB;KNDC1;RASGEF1B;RGL2;ADRB1;RASGEF1A
cAMP binding	HCN2;CNGA2;PRKAR1B;HCN4;CNGA4;PDE4B;PDE10A;BVES;PRKAR2A
guanyl-nucleotide exchange factor activity	TAGAP;KNDC1;RINL;FFAR1;ARHGEF7B;NET1;RAPGEFL1;ARHGEF3L;ARHGEF7A
protein binding	SFRP1;EXOC7;CDKN1A;ITCH;CCDC11;PTK2;RFX1;AHNAK;DHRS2

RAPGEF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAPGEF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAPGEF4.

C16orf45; ATXN1; SLC22A7; 3',5'-cyclic amp

Hwang, JY; Sim, X; et al. Genome-Wide Association Meta-analysis Identifies Novel Variants Associated With Fasting Plasma Glucose in East Asians. DIABETES 64:291-298(2015).

Vadnais, ML; Aghajanian, HK; et al. Signaling in Sperm: Toward a Molecular Understanding of the Acquisition of Sperm Motility in the Mouse Epididymis. BIOLOGY OF REPRODUCTION 89:-(2013).