rnf34
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  • Official Full Name
  • ring finger protein 34, E3 ubiquitin protein ligase
  • Background
  • The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
  • Synonyms
  • RNF34; ring finger protein 34, E3 ubiquitin protein ligase; ring finger protein 34; E3 ubiquitin-protein ligase RNF34; FLJ21786; RIF; RIFF; caspase regulator CARP1; RING finger protein RIFF; FYVE-RING finger protein MOMO; caspases-8 and -10-associated RIN
Cat.#:RNF34-682HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human RNF34 Protein, MYC/DDK-tagged
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Cat.#:RNF34-336HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ring finger protein 34, E3 ubiquitin protein ligase, His-tagged
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Cat.#:RNF34-638HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human RNF34 Protein, GST-tagged, Active
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Cat.#:RNF34-14344MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RNF34 Protein
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Cat.#:RNF34-5081RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RNF34 Protein
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Cat.#:RNF34-3942RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey RNF34 Protein, His-tagged
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Cat.#:RNF34-1337CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RNF34
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Cat.#:RNF34-2279HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RNF34 293 Cell Lysate
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Involved Pathway

RNF34 involved in several pathways and played different roles in them. We selected most pathways RNF34 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF34 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
KIFAP3; LILRA1; KIF4A; TRIM9; SIGLEC6; ASB3; SLAMF6; TPP2; DNM1; EGFR
Antigen processing: Ubiquitination &
ASB6; STUB1; UFL1; UBR1; SH3RF1; UBE2V1; FBXO44; UBA5; ASB3; UBE2F
Proteasome degradation
ASB7; SH3RF1; ASB2; TRIM11; DTX3L; NPEPPS; UBE2U; UBE2F; WSB1; ASB17
Class I MHC mediated antigen processing &
CYBA; LRR1; UBE2L6; SEC61B; TRIM69; CYBB; FBXO3; CTSL1; ARIH2; UBE2V1
presentation
RNF220; FCGR1B; LRR1; ERAP1; TRIM63; MKRN1; ASB4; ASB6; RNF144B; TRIM39
Immune System
KPNA3; TRIM48; RAET1E; ASB10; NCR3LG1; RNF220; CFD; PPIAL4A; RNF25; PANX1B

Protein Function

RNF34 has several biochemical functions, for example, ligase activity, p53 binding, phosphatidylinositol phosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF34 itself. We selected most functions RNF34 had, and list some proteins which have the same functions with RNF34. You can find most of the proteins on our site.
Function
Related Protein
Function ligase activity
Related Protein TNFAIP3; ZSWIM2; NAPRT; RNF169; UBE2L3B; NEURL1B; PIAS4; TRIM50; ACSF2; TTLL5
Function p53 binding
Related Protein TP53BP1; ZFP346; NUAK1; RNF20; TP63; BANP; ANKRD1; CDK5; AXIN1; ZNF385A
Function phosphatidylinositol phosphate binding
Related Protein RNF34; SNX11; ANKFY1; GAP43; RPH3A; PLCD1
Function protein binding
Related Protein SPINK7; ID1; SPANXD; TEF; POU2F3; ZNF544; OSR2; SIX5; BARD1; DHPS
Function ubiquitin protein ligase activity
Related Protein RBX1; PPIL2; MED21; UBE2N; MSL2A; UBE3C; CDK8; HECW1B; HECW2; UBE2G1B
Function ubiquitin protein ligase binding
Related Protein RNF20; TRAF4; TRIM28; TUBA1B; UBE2T; UBE2H; MAGEA2B; UBOX5; SMC6; IKBKG
Function zinc ion binding
Related Protein KAT7; CBLB; ZDHHC16A; PHC2B; QPCTL; TTC3; PML; RBM14A; NEIL1; TLL1

Interacting Protein

RNF34 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF34 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF34.
APPBP2; CASP8; UBA1; UBE2N; UBE2V1; phosphatidylinositol-3-phosphate; phosphatidylinositol; phosphatidylinositol 4-phosphates; TRIM23; UBE2H; CASP10; UBE2F; PHF7