RNF34 Protein, ring finger protein 34, E3 ubiquitin protein ligase


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Official Full Name ring finger protein 34, E3 ubiquitin protein ligase
Background The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Synonyms RNF34; ring finger protein 34, E3 ubiquitin protein ligase; ring finger protein 34; E3 ubiquitin-protein ligase RNF34; FLJ21786; RIF; RIFF; caspase regulator CARP1; RING finger protein RIFF; FYVE-RING finger protein MOMO; caspases-8 and -10-associated RIN
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human RNF34-2279HCL Recombinant Human RNF34 293 Cell Lysate HEK293 N/A
    Human RNF34-336H Recombinant Human ring finger protein 34, E3 ubiquitin protein ligase, His-tagged E.coli His
    Human RNF34-638H Recombinant Human RNF34 Protein, GST-tagged, Active Insect Cell GST
    Human RNF34-682H Recombinant Human RNF34 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse RNF34-14344M Recombinant Mouse RNF34 Protein Mammalian Cell His
    Rat RNF34-5081R Recombinant Rat RNF34 Protein Mammalian Cell His
    Rhesus Macaque RNF34-3942R Recombinant Rhesus monkey RNF34 Protein, His-tagged Mammalian Cell His
    Chicken RNF34-1337C Recombinant Chicken RNF34 Mammalian Cell His

    RNF34 involved in several pathways and played different roles in them. We selected most pathways RNF34 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &amp, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF34 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adaptive Immune System LILRA3; SIGLEC8; ATG7; KIF26A; IGHM; OSCAR; MAP3K8; CTSK; NPEPPS; OSBPL1A
    Antigen processing: Ubiquitination &amp UBE2F; TRIM50; TPP2; RNF123; ASB3; SPSB2; ASB13; FBXO17; TRIM63; ASB9
    Proteasome degradation DTX3L; ASB11; UBE2V2; RNF220; ASB9; LTN1; TRIM39; RNF111; CMTM2A; UCHL3
    Class I MHC mediated antigen processing &amp WWP1; ASB6; UBE2V1; PJA1; KLHL20; RNF182; VPRBP; B2ML; STUB1; ASB3
    presentation KLHL20; PJA1; ASB8; TRIM50; GAN; UBA5; ERAP1; ATG7; RNF34; TRIM63
    Immune System KPNA3; NLRP4C; MASP2; IFI16; TXN; PPAPDC1B; MGC174155; IFI35; AF251705; IFIT11

    RNF34 has several biochemical functions, for example, ligase activity, p53 binding, phosphatidylinositol phosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF34 itself. We selected most functions RNF34 had, and list some proteins which have the same functions with RNF34. You can find most of the proteins on our site.

    Function Related Protein
    ligase activity SMURF1; ACSF2; BRAP; DZIP3; MARCH6; UBE2D1B; SHPRH; PELI2; CCNB1IP1; RANBP2
    p53 binding RFFL; CDKN2AIP; HSPD1; RNF34; EP300; TRP63; USP10; GSK3B; SMYD2; DAXX
    phosphatidylinositol phosphate binding RPH3A; RNF34; PLCD1; SNX11; GAP43; ANKFY1
    protein binding SNCAIP; KCP; RYR1; SMNDC1; TPRGL; ATF2; DRAXIN; THY1; TAS2R16; Ccl27a
    ubiquitin protein ligase activity RNF19B; MARCH8; RNF2; PPIL2; RNF121; SIAH1; MED10; UBE2B; BRAP; TRIM72
    ubiquitin protein ligase binding TMEM173; GABARAP; UBE2S; UBE2V2; TRIM28; SPOP; BLZF1; RB1; LC3; LTBR
    zinc ion binding KDM1B; RNF32; ZMAT4; RORB; CNOT4; PIAS4A; TRIM16; CSRP1B; MYLIPB; LONRF1L

    RNF34 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF34 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF34.

    APPBP2; CASP8; UBA1; UBE2N; UBE2V1; phosphatidylinositol-3-phosphate; phosphatidylinositol; phosphatidylinositol 4-phosphates; TRIM23; UBE2H; CASP10; UBE2F; PHF7

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