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RNF6

Official Full Name

ring finger protein (C3H2C3 type) 6
Overview

The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed.
Synonyms

RNF6; ring finger protein (C3H2C3 type) 6; E3 ubiquitin-protein ligase RNF6; DKFZp686P0776; RING H2 protein RNF 6; Ring finger protein 6; RING H2 protein; RING H2 protein RNF6; RNF 6; OTTHUMP00000018154; OTTHUMP00000018155; OTTHUMP00000018156; RING-H2 protein RNF-6;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	RNF6-2348H	Recombinant Human RNF6, His-tagged	E.coli	His	1-300aa	$319 / 25ug
Human	RNF6-1529HCL	Recombinant Human RNF6 cell lysate		N/A		Inquiry
Mouse	RNF6-14353M	Recombinant Mouse RNF6 Protein	Mammalian Cell	His		Inquiry
Mouse	RNF6-7689M	Recombinant Mouse RNF6 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	RNF6-7689M-B	Recombinant Mouse RNF6 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
RNF6 Related Articles

RNF6 involved in several pathways and played different roles in them. We selected most pathways RNF6 participated on our site, such as Adaptive Immune System, Androgen receptor signaling pathway, Antigen processing: Ubiquitination &amp, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Adaptive Immune System	TREML1;MGC174857;ASB4;CD96;TREML2;FGF18B;AGO2;STIM1B;FGF20A
Androgen receptor signaling pathway	HTATIP;NCOA2;CTNNB1;GNB2L1;JUN;RANBP9;ETV5A;KDM1A;KAT7B
Antigen processing: Ubiquitination &amp	ARIH2;UBE2V1;RBCK1;UBE2V2;RNF123;BLMH;FBXO3;RNF41;GAN
Proteasome degradation	TRIM63;RNF138;ASB14;UBE2V1;UBE2U;VPRBP;UBR1;FBXO27;UBA5
Class I MHC mediated antigen processing &amp	CTSL2;CTSL1;CTSS;ASB4;ASB14;TRIM41;KLHL21;FBXO27;ASB13
presentation	RNF182;RNF41;UBE2E3;ASB18;RNF6;MKRN1;ERAP1;FBXO17;RNF19B
Immune System	DYNC1H1;CTSLL;LILRA2;CD200R2;NLRP4;TRIM48;RIPK3;KPNA3;OSCAR

RNF6 has several biochemical functions, for example, DNA binding, androgen receptor binding, ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF6 itself. We selected most functions RNF6 had, and list some proteins which have the same functions with RNF6. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	PTF1A;PPARG;CENPW;LYL1;HMGXB3;NR4A2;GBX1;RYBP;KDM5D
androgen receptor binding	PRPF6;PRMT2;SMARCA4;DAXX;NCOA3;PARK7;PIAS1;FOXP1;NCOA1
ligase activity	RC3H2;ITCHA;TRIM6;MARCH5;BTR22;MARCH3;ARIH2;BRAP;UBE2G1A
protein binding	LASP1;KRT5;PRPF40A;ZMYND11;CAPRIN2;NID2;S100A13;CCNG1;NARG2
ubiquitin protein ligase activity	UBR5;FLJ11011L;RAD18;UBE2V1;MARCH1;UBE2A;TRIM24;RBBP6;UBE2S
ubiquitin-protein transferase activity	RNF38;TRAF7;NLRC4;TRAF3;ITCH;PRKCQ;MARCH8;RNF41;CBLB
zinc ion binding	BMI1A;MT1H;CTCF;ZCCHC17;ZFP276;ADAM17;POLR2I;CA3;TRIM35-24

RNF6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF6 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF6.

AR; UBE2H; bmf_human_gene; rel1_human_gene; klk3_human_gene; RNF14

Stoll, H; et al. Filling the Gap between Pseudopotential and All-Electron Schemes: Frozen-Core Calculations with Efficient Use of Density-Fitting. JOURNAL OF CHEMICAL THEORY AND COMPUTATION 10:3857-3862(2014).

Linn, DE; Yang, X; et al. Differential Regulation of Androgen Receptor by PIM-1 Kinases via Phosphorylation-dependent Recruitment of Distinct Ubiquitin E3 Ligases. JOURNAL OF BIOLOGICAL CHEMISTRY 287:22959-22968(2012).