sec23ip
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  • Official Full Name
  • SEC23 interacting protein
  • Background
  • This gene encodes a member of the phosphatidic acid preferring-phospholipase A1 family. The encoded protein is localized to endoplasmic reticulum exit sites and plays a critical role in ER-Golgi transport as part of the multimeric coat protein II complex. An orthologous gene in frogs is required for normal neural crest cell development, suggesting that this gene may play a role in Waardenburg syndrome neural crest defects. Alternatively spliced transcript variants have been observed for this gene.
  • Synonyms
  • SEC23IP; SEC23 interacting protein; SEC23-interacting protein; P125; MSTP053; Phospholipase; Sec23 interacting protein p125; OTTHUMP00000020613; P125A
Cat.#:SEC23IP-2564HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SEC23IP, GST-tagged
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Cat.#:SEC23IP-4711ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SEC23IP
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Cat.#:SEC23IP-1992HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SEC23IP 293 Cell Lysate
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Involved Pathway

SEC23IP involved in several pathways and played different roles in them. We selected most pathways SEC23IP participated on our site, such as Asparagine N-linked glycosylation, COPII (Coat Protein 2) Mediated Vesicle Transport, ER to Golgi Anterograde Transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with SEC23IP were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Asparagine N-linked glycosylation
PPP6R1; MPDU1B; SLC35A1; ZNF408; MCFD2; TMED2; TRAPPC4; YKT6; MAGT1; OS9
COPII (Coat Protein 2) Mediated Vesicle Transport
GOLGA2; CTSC; TRAPPC4; TRAPPC2; CNIH3; TRAPPC5; SEC22C; USO1; YKT6; GORASP1
ER to Golgi Anterograde Transport
NAPB; CNIH3; LMAN2L; CNIH; TRAPPC3; LMAN2; GOLGA2; SEC22C; YKT6; CTAGE5
Membrane Trafficking
ARCN1; EXOC5; NAPB; NECAP1; YIPF6; SNX9A; TRAPPC10; PICALMA; PPP6R1; COPB2
Metabolism of proteins
FKBP14; GALNT6; SLC30A8; TRAPPC6BL; TIMM23; ADAMTS18; ADAMTS4; TRAPPC9; PHC3; COX17
Post-translational protein modification
CNIH; ZNF408; ARSF; TRAPPC4; MUC4; DPH2; ADAMTS20; DOHH; B3GALTL; MUC1
Transport to the Golgi and subsequent modification
TRAPPC2L; SCFD1; NAPB; TMED10; CNIH; MIA3; TRAPPC3; CNIH2; TRAPPC6B; LMAN2L
Vesicle-mediated transport
TRAPPC1; ARCN1; SEC22A; PICALM; SNX9; SNAPIN; TRAPPC10; TGOLN2; TBC1D8B; BLOC1S1

Protein Function

SEC23IP has several biochemical functions, for example, metal ion binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SEC23IP itself. We selected most functions SEC23IP had, and list some proteins which have the same functions with SEC23IP. You can find most of the proteins on our site.
Function
Related Protein
Function metal ion binding
Related Protein ZFYVE26; PPM1L; ZNF507; ZC3H15; HBBE2; ZNF207B; TRIM35-19; DNAJA1; NT5C; ZNF831
Function poly(A) RNA binding
Related Protein HNRNPR; NSA2; EIF2S1; LGALS3; HIST1H4D; TARDBP; TBL3; EIF1; DCN; HIST1H4H
Function protein binding
Related Protein TMF1; SMIM3; RSPO1; RAB18; MTRR; PPP1R12A; EP400; MKNK2; AKAP8L; CAPNS2

Interacting Protein

SEC23IP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEC23IP here. Most of them are supplied by our site. Hope this information will be useful for your research of SEC23IP.
SSC5D; HSPB11; PDCD6; Sec24c; Kif4; PRKD2; Vps28; TIMM13

SEC23IP Related Articles

de Barsy, M; Mirabella, A; et al. A Brucella abortus cstA mutant is defective for association with endoplasmic reticulum exit sites and displays altered trafficking in HeLa cells. MICROBIOLOGY-SGM 158:2610-2618(2012).