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SHC3

Official Full Name

SHC (Src homology 2 domain containing) transforming protein 3
Overview

SHC-transforming protein 3 is a protein that in humans is encoded by the SHC3 gene.
Synonyms

SHC3; SHC (Src homology 2 domain containing) transforming protein 3; src homology 2 domain containing transforming protein C3; SHC-transforming protein 3; N Shc; NSHC; SHCC; N-Shc; Neuronal Shc; Protein Rai; Rai; SH2 domain protein C3; SHC protein C; SHC-like protein, neuronal; SHC-transforming protein C; SHC3_HUMAN; Src homology 2 domain-containing transforming protein; Src homology 2 domain-containing-transforming protein C3; src homology 2 domain-containing transforming protein C3;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rhesus Macaque

Source

E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
His|GST
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SHC3-2655H	Recombinant Human SHC3, GST-tagged	E.coli	GST	C-term-351aa	$319 / 25ug
Human	SHC3-1277H	Recombinant Human SHC3 protein, His & GST-tagged	E.coli	His/GST	Val188~Gln433 (Accession # Q92529)	Inquiry
Human	SHC3-1602HCL	Recombinant Human SHC3 cell lysate		N/A		Inquiry
Human	SHC3-5922H	Recombinant Human SHC3 Protein (Val188-Gln433), N-GST tagged	E.coli	N-GST	Val188-Gln433	Inquiry
Mouse	SHC3-15092M	Recombinant Mouse SHC3 Protein	Mammalian Cell	His		Inquiry
Mouse	SHC3-8143M-B	Recombinant Mouse SHC3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	SHC3-8143M	Recombinant Mouse SHC3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	SHC3-4193R	Recombinant Rhesus monkey SHC3 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	SHC3-4009R	Recombinant Rhesus Macaque SHC3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	SHC3-4009R-B	Recombinant Rhesus Macaque SHC3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
SHC3 Related Articles
SHC3 Related Signal Pathway

SHC3 involved in several pathways and played different roles in them. We selected most pathways SHC3 participated on our site, such as ErbB signaling pathway, Ras signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SHC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
ErbB signaling pathway	PAK2B;MAP2K1;EGFRA;CAMK2G;PAK6B;PIK3CA;NCK2;RAF1A;PTK2AA
Ras signaling pathway	ANGPT4;CSF1;RALBP1;FGF4;PAK6;FGF5;PLA2G3;FGF9;EFNA4
Chemokine signaling pathway	XCR1;CCL26;VAV2;CCR1;DOCK2;GRK6;Ccl21c;PTK2;FGR
Phospholipase D signaling pathway	PIK3CG;RHEB;MAP2K2;FCER1A;PPAP2B;PDGFRB;GRB2;PPAP2A;AKT1
Focal adhesion	THBS1;RAC3A;CDC42L;FLT4;ITGA2;KDR;RAP1AA;TNK1;MYLPF
Natural killer cell mediated cytotoxicity	KIR2DL3;IFNA10;PPP3CA;KLRC3;MAPK3;PLCG2;FCER1G;PIK3R3;SH2D1B
Neurotrophin signaling pathway	IKBKB;RAF1;RPS6KA1;BDNF;SOS1;PIK3R2;AKT2;CALM2;GSK3B
Insulin signaling pathway	G6PC3;FLOT2A;CALM2A;ELK1;INPP5K;FLOT1B;TRIP10A;SOCS1;PIK3R2
Estrogen signaling pathway	KCNJ5;CREB5;NOS3;HSP90AB1;PIK3R1;HSPA1L;HSPA1A;MMP2;AKT1
Prolactin signaling pathway	NFKB1;GSK3B;MAP2K2;MAPK9;PIK3R2;SHC4;INS;PRP2;LHCGR
Alcoholism	GNGT2;HIST1H2BN;GNG10;GNG5;HIST1H2BC;GNAS;H2AFZ;HIST3H3;HIST1H2AD
Bacterial invasion of epithelial cells	WASF1;CBLC;DNM3;ITGA5;SEPT12;DNM2;PIK3CD;HCLS1;ACTB
Glioma	PTEN;PDGFA;PIK3CD;CCND1;AKT2;CAMK2A;CALM4;IGF1R;PDGFB
Chronic myeloid leukemia	CBLC;GRB2;ABL1;PIK3R5;CRK;PIK3R2;ARAF;CBL;RELA

SHC3 has several biochemical functions, for example, protein binding, protein kinase binding, receptor tyrosine kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SHC3 itself. We selected most functions SHC3 had, and list some proteins which have the same functions with SHC3. You can find most of the proteins on our site.

Function	Related Protein
protein binding	CEP104;pab1;SMAD5;MEPE;NAA50;FTSJ3;NIF3L1;TSN;UBASH3A
protein kinase binding	RNF138;CCNL1;STAP1;TP73;DOK7;NGFRAP1;ELAVL1;FAM83D;ATP1A1
receptor tyrosine kinase binding	ANGPT4;CPNE3;PCNA;ANGPT2;PTPN11;PTPN2;SOCS5;TP53;TRP53
signal transducer activity	LSP1;OLFR867;OLFCG2;NPFFR1L2;RHOC;PARAPINOPSINB;ZP3;ECT2;VMN1R43

SHC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SHC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SHC3.

GOLGA2; KRT31; KRT40; EGFR; ERBB2; MET; AR; KIT; ERBB3; GAB1

Mierzejewska, K; Heo, J; et al. Genome-wide analysis of murine bone marrow-derived very small embryonic-like stem cells reveals that mitogenic growth factor signaling pathways play a crucial role in the quiescence and ageing of these cells. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 32:281-290(2013).

Adams, SJ; Aydin, IT; et al. GAB2-a Scaffolding Protein in Cancer. MOLECULAR CANCER RESEARCH 10:1265-1270(2012).