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SIN3A

Official Full Name

SIN3 transcription regulator homolog A (yeast)
Overview

The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex.
Synonyms

SIN3A; SIN3 transcription regulator homolog A (yeast); SIN3 homolog A, transcription regulator (yeast); paired amphipathic helix protein Sin3a; DKFZP434K2235; KIAA0700; transcriptional regulator, SIN3A; transcriptional corepressor Sin3a; transcriptional co-repressor Sin3A; SIN3 homolog A, transcription regulator; histone deacetylase complex subunit Sin3a; FLJ90319;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rhesus Macaque

Source

E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SIN3A-2676H	Recombinant Human SIN3A, GST-tagged	E.coli	GST	1-156aa	$319 / 25ug
Mouse	SIN3A-15141M	Recombinant Mouse SIN3A Protein	Mammalian Cell	His		Inquiry
Mouse	SIN3A-8177M-B	Recombinant Mouse SIN3A Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	SIN3A-8177M	Recombinant Mouse SIN3A Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	SIN3A-4205R	Recombinant Rhesus monkey SIN3A Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	SIN3A-4021R	Recombinant Rhesus Macaque SIN3A Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	SIN3A-4021R-B	Recombinant Rhesus Macaque SIN3A Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	SIN3A-5539C	Recombinant Chicken SIN3A	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SIN3A Related Articles

SIN3A involved in several pathways and played different roles in them. We selected most pathways SIN3A participated on our site, such as Thyroid hormone signaling pathway, Huntingtons disease, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIN3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Thyroid hormone signaling pathway	ACTB;TSC2;MAP2K1;MED27;BAD;PLCB3;PRKACG;ATP1A3;ATP1B2
Huntingtons disease	TBPL1;RCOR1;COX8A;NDUFA1;UCP1;HDAC1;SOD2;SIN3A;POLR2F
Transcriptional misregulation in cancer	PAX3;CCND2;MMP9;BMP2K;CD40;ASPSCR1;NTRK1;MLL1;LMO2

SIN3A has several biochemical functions, for example, RNA polymerase II activating transcription factor binding, RNA polymerase II repressing transcription factor binding, RNA polymerase II transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SIN3A itself. We selected most functions SIN3A had, and list some proteins which have the same functions with SIN3A. You can find most of the proteins on our site.

Function	Related Protein
RNA polymerase II activating transcription factor binding	SIN3A;LMO2;PITX2;CREBBP;EOMES;SMAD3;RB1;EP300;ZFPM1
RNA polymerase II repressing transcription factor binding	BBS2;BBS7;RBBP8;GTF2A2;HDAC1;PPARA;CHD4;MIXL1;TCF7L2
RNA polymerase II transcription corepressor activity	HDAC1;RERE;TFAP2B;ELANE;TLE1;HEYL;SIN3A;TBX15;NFIB
chromatin binding	KLF6A;MNT;RUNX2;CDC45;BAHD1;SMAD2;SATB1;MSH6;PPARG
contributes_to histone deacetylase activity	SUDS3;SIN3B;BRMS1L;BRMS1;SALL1;SIN3A;BRMS1LA;SIN3AA
protein binding	EPB41B;RASGRP3;FAM156A;APOL1;PHF23;SLC48A1;KCTD9;SEMG2;FGF13
protein deacetylase activity	HDAC4;HDAC10;HDAC9;SIN3A;HDAC1;SIRT2;HDAC5;HDAC3;HDAC2
transcription factor activity, sequence-specific DNA binding	HOXA13;SOX11A;LMX1B;GPBP1L1;CARF;SLC2A4RG;SIX4;CREBBP;HMGB2
transcription regulatory region sequence-specific DNA binding	NFE2L3;SOX4;DDIT3;CREB3L3;POU2F1;HIF1AL;TBX18;NR5A1;NKX3

SIN3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIN3A here. Most of them are supplied by our site. Hope this information will be useful for your research of SIN3A.

HDAC1; HDAC2; SKI; HCFC1

Sugimoto, T; Tomita, A; et al. Escape mechanisms from antibody therapy to lymphoma cells: Downregulation of CD20 mRNA by recruitment of the HDAC complex and not by DNA methylation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 390:48-53(2009).

Zhao, X; Jankovic, V; et al. Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity. GENES & DEVELOPMENT 22:640-653(2008).