sin3a
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  • Official Full Name
  • SIN3 transcription regulator homolog A (yeast)
  • Background
  • The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex.
  • Synonyms
  • SIN3A; SIN3 transcription regulator homolog A (yeast); SIN3 homolog A, transcription regulator (yeast); paired amphipathic helix protein Sin3a; DKFZP434K2235; KIAA0700; transcriptional regulator, SIN3A; transcriptional corepressor Sin3a; transcriptional co-repressor Sin3A; SIN3 homolog A, transcription regulator; histone deacetylase complex subunit Sin3a; FLJ90319
Cat.#:SIN3A-2676HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIN3A, GST-tagged
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Cat.#:SIN3A-15141MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SIN3A Protein
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Cat.#:SIN3A-4205RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SIN3A Protein, His-tagged
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Cat.#:SIN3A-5539CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SIN3A
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Involved Pathway

SIN3A involved in several pathways and played different roles in them. We selected most pathways SIN3A participated on our site, such as Thyroid hormone signaling pathway, Huntingtons disease, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIN3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Thyroid hormone signaling pathway
PLCD1; PRKCA; RCAN2; KRAS; RCAN1; MAP2K2; PLCG1; PLCG2; ATP1A4; PLN
Huntingtons disease
UQCRH; NDUFS7; ATP5A1; CREB3L2; NDUFA10; DNALI1; POLR2J2; NDUFS2; APAF1; UQCRFS1
Transcriptional misregulation in cancer
BIRC3; PLAT; TLX1; RXRG; ETV1; MMP9; IL6; SPINT1; DDX5; RELA

Protein Function

SIN3A has several biochemical functions, for example, RNA polymerase II activating transcription factor binding, RNA polymerase II repressing transcription factor binding, RNA polymerase II transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SIN3A itself. We selected most functions SIN3A had, and list some proteins which have the same functions with SIN3A. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II activating transcription factor binding
Related Protein NHLH2; IFI27; SMAD3; BEX1; NEUROD1; HNF4A; HIPK2; TBX3; CREBBP; PITX2
Function RNA polymerase II repressing transcription factor binding
Related Protein BBS2; STAT3; HDAC2; RBPJ; DMAP1; TCERG1; SIN3A; BBS4; GATA6; BBS10
Function RNA polymerase II transcription corepressor activity
Related Protein SIN3AA; HEYL; TXLNB; UXT; CTBP1; SOX3; TCERG1; HDGF; NFIB; OLIG3
Function chromatin binding
Related Protein MBD1; TBL1Y; FOXN4; LDB1; SNAI2; LHX2; NKX2-5; APTX; FABP1; ZMYND11
Function contributes_to histone deacetylase activity
Related Protein SIN3A; SIN3B; SIN3AA; SALL1; BRMS1L; BRMS1; BRMS1LA; SUDS3
Function protein binding
Related Protein EHMT1; RARRES2; HLA-DRB3; PRKG1; NCF4; CSF2RA; RIN1; CDC37; TNNI1; ANGPTL4
Function protein deacetylase activity
Related Protein HDAC1; HDAC5; HDAC10; SIRT1; HDAC4; HDAC3; SIN3A; SIRT2; HDAC9; HDAC2
Function transcription factor activity, sequence-specific DNA binding
Related Protein LCOR; ZNF157; ZFP30; BCL3; FOXC1B; YEATS4; NFATC1; HOXB4A; ZSCAN10; MECOM
Function transcription regulatory region sequence-specific DNA binding
Related Protein PER2; SFPQ; NFE2L1; FOXJ1; EGR1; SUV39H2; FOXN1; TBX18; BAHD1; MKL1

Interacting Protein

SIN3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIN3A here. Most of them are supplied by our site. Hope this information will be useful for your research of SIN3A.
HDAC1; HDAC2; SKI; HCFC1

SIN3A Related Articles

Sugimoto, T; Tomita, A; et al. Escape mechanisms from antibody therapy to lymphoma cells: Downregulation of CD20 mRNA by recruitment of the HDAC complex and not by DNA methylation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 390:48-53(2009).
Zhao, X; Jankovic, V; et al. Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity. GENES & DEVELOPMENT 22:640-653(2008).