slc9a1
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  • Official Full Name
  • solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
  • Background
  • SLC9A1 (NHE1), a member of the Na+/H+ exchanger family, is a ubiquitous membrane protein that regulates intracellular pH and cell volume. Furthermore, SLC9A1 is known to interact with the actin cytoskeleton. Fibroblasts expressing mutated NHE1 that fails
  • Synonyms
  • SLC9A1; solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1; APNH, NHE1, solute carrier family 9 (sodium/hydrogen exchanger), isoform 1 (antiporter, Na+/H+, amiloride sensitive) , solute carrier family 9 (sodium/hydrogen ex
Cat.#:SLC9A1-5584RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SLC9A1 Protein
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Cat.#:SLC9A1-3435CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SLC9A1
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Cat.#:SLC9A1-6293ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SLC9A1
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Cat.#:SLC9A1-1695HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SLC9A1 293 Cell Lysate
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Involved Pathway

SLC9A1 involved in several pathways and played different roles in them. We selected most pathways SLC9A1 participated on our site, such as cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC9A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
cAMP signaling pathway
NFATC1; RAC3; ACOX1; ARAP3; HCN2; PIK3CG; FXYD1; PIK3CD; Adcy4; PTGER3
Cardiac muscle contraction
ATP1A2; MYH7; COX8A; COX7B2; TPM4B; CACNA2D1; COX5A; ATP1A2A; COX8C; CACNG8
Adrenergic signaling in cardiomyocytes
ATP2B1; CACNA1SB; CACNG4; MAPK12A; ADRA1D; GNA11A; PIK3CG; PPP2R2A; CALML3; Adcy4
Regulation of actin cytoskeleton
MYL2; INSB; FGF21; ARPC5LB; ARHGEF6; RDX; WASLA; VIL1; PDGFRA; CFL2L
Thyroid hormone signaling pathway
PIK3R2; PRKCB; ACTB; NCOR1; PLCG2; HDAC1; RXRB; SLC16A2; MED4; MED14
Salivary secretion
ATP1A2; SLC9A1; PRB1; RYR3; ATP1A4; CALM2; ATP1B4; CALML3; PRKG2; LYZ
Gastric acid secretion
HRH2; PRKACA; GNAQ; PRKACG; ATP4B; KCNJ1; KCNJ16; ATP1A4; CALM4; CAMK2G
Pancreatic secretion
PNLIPRP1; CCKAR; ATP1B2; CTRB1; PLCB3; GNAS; PLA2G2D; RYR2; Slc4a2; PLA2G10
Bile secretion
ATP1B1; SLC22A8; SLCO1A5; SLC9A3; ATP1A4; NR0B2; ADCY7; SLCO1B1; ABCB1A; Abcb1b
Proteoglycans in cancer
PIK3R2; ITGA5; COL21A1; WNT8A; SOS1; SDC2; HSPG2; PRKCB; CAV3; ACTB

Protein Function

SLC9A1 has several biochemical functions, for example, calcium-dependent protein binding, calmodulin binding, phosphatidylinositol-4,5-bisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC9A1 itself. We selected most functions SLC9A1 had, and list some proteins which have the same functions with SLC9A1. You can find most of the proteins on our site.
Function
Related Protein
Function calcium-dependent protein binding
Related Protein DMBT1; MYO5A; SNAP25; SYN1; MMP13; CPNE3; KOP; CALM1; STMN2; S100A4
Function calmodulin binding
Related Protein RYR2; SLC14A2; OBSCN; KCNN3; EEA1; PPP3CA; NDUFAF4; MYH13; MKNK2A; KCNN1
Function phosphatidylinositol-4,5-bisphosphate binding
Related Protein D6WSU116E; ACTN2; ADAP2; KCNQ1; FAM123B; FAM123A; RS1; SYT1; MYO1G; JPH2
Function protein binding
Related Protein SETDB2; DNM1L; MARK4; VIL1; SEC16B; PIN4; FBXL15; FBXW2; H2AFX; HIST1H2BB
Function protein binding, bridging
Related Protein CNTLN; MEN1; NCK1; CSTA; SH2D1B; FBXW7; NEFL; TIRAP; TJP2; TRIM22
Function protein complex scaffold
Related Protein MAP2K2; MAGI1B; CAV2; CAV3; CNOT1; ITSN1; AKAP13; AKAP6; MAGI3; ISCU
Function protein phosphatase 2B binding
Related Protein SOD1; SLC9A1; BAD; ATP2B4; MYOZ2; AKAP1; PPP3CB; AKAP5
Function sodium:proton antiporter activity
Related Protein SLC9A3; SLC9A8; SLC9A4; SLC9A9; SLC9A6B; SLC9A7; SLC9A5; SLC9A1; SLC9A3.1; SLC9A6A
Function sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential
Related Protein SLC9A1
Function solute:proton antiporter activity
Related Protein NHEDC1; SLC9A6A; SLC9A6B; SLC9A3.1; SLC9B2; SLC9A9; SLC9A4; TMCO3; SLC9A10; SLC9A1

Interacting Protein

SLC9A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC9A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC9A1.
YWHAB; MAP3K7; CHP2; MAP4K4; UBE2I; MDFI; Rab5c; YWHAZ; Gbf1; Taf15; AP4S1; Mad2l1