slc9a1
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  • Official Full Name
  • solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
  • Background
  • SLC9A1 (NHE1), a member of the Na+/H+ exchanger family, is a ubiquitous membrane protein that regulates intracellular pH and cell volume. Furthermore, SLC9A1 is known to interact with the actin cytoskeleton. Fibroblasts expressing mutated NHE1 that fails
  • Synonyms
  • SLC9A1; solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1; APNH, NHE1, solute carrier family 9 (sodium/hydrogen exchanger), isoform 1 (antiporter, Na+/H+, amiloride sensitive) , solute carrier family 9 (sodium/hydrogen ex
Cat.#:SLC9A1-5584RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SLC9A1 Protein
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Cat.#:SLC9A1-3435CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SLC9A1
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Cat.#:SLC9A1-6293ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SLC9A1
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Cat.#:SLC9A1-1695HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SLC9A1 293 Cell Lysate
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Involved Pathway

SLC9A1 involved in several pathways and played different roles in them. We selected most pathways SLC9A1 participated on our site, such as cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC9A1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
cAMP signaling pathway
PPARA; ATP1A3; SLC9A1; MLLT4; AMH; CREB3L2; HTR1E; GRIA1; PRKACG; ATP1A4
Cardiac muscle contraction
ATP1A1; ATP1A3B; TMEM8C; TNNI3; FXYD2; RYR2; TPM1; SLC8A1; CACNA2D3; VMHC
Adrenergic signaling in cardiomyocytes
PPP2R2BB; SLC14A2; ATP2B2; MAPK12A; ACTC1A; CALML5; PPP1CB; CACNA1C; ADRa1A; FXYD2
Regulation of actin cytoskeleton
GSNA; CDC42L2; ITGA10; MOS; ARPC5L; FGF3; ITGB2; LIMK2; ITGA11A; RAC3B
Thyroid hormone signaling pathway
MED24; MED12L; PIK3CA; NOTCH4; PIK3R5; PRKACB; SLCO1C1; PDPK1; PLCB3; MED27
Salivary secretion
AQP5; ATP1B3; Adcy4; STATH; PLCB3; CST5; HTN1; TRPV6; ITPR3; PMAP-36
Gastric acid secretion
MYLK4; CALM1; KCNE2; KCNJ1; CALML3; KCNJ2; GNAI2; HRH2; SLC9A1; KCNJ16
Pancreatic secretion
PRSS3; Car2; ITPR3; CA2; RAC1; ATP2B1; GNAS; PRKCG; PLA2G2A; PLA2G2F
Bile secretion
ABCB11; ADCY7; SLCO1A4; SLC4A4; NR1H4; ATP1A4; SLCO1A5; FAM84B; Car2; AQP1
Proteoglycans in cancer
HIF1A; Ctsl; WNT5A; WNT8B; TWIST2; GAB1; HSPG2; NUDT16L1; ACTB; SOS1

Protein Function

SLC9A1 has several biochemical functions, for example, calcium-dependent protein binding, calmodulin binding, phosphatidylinositol-4,5-bisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC9A1 itself. We selected most functions SLC9A1 had, and list some proteins which have the same functions with SLC9A1. You can find most of the proteins on our site.
Function
Related Protein
Function calcium-dependent protein binding
Related Protein CCDC167; FCN2; MYO5A; DDX5; SLC9A1; PDCD6IP; S100A1; S100A11; SELP; PLSCR3
Function calmodulin binding
Related Protein ITPKA; RASGRF2B; RGS4; PPP3R1; CDK5RAP2; RYR2; CNN3; MAP6D1; CAMK1D; MKNK2A
Function phosphatidylinositol-4,5-bisphosphate binding
Related Protein LDLRAP1; FAM123A; KCNJ2; RAG2; ACTN2; SESTD1; STXBP6; COMMD1; CHMP3; PARD3
Function protein binding
Related Protein BLOC1S5; HIST1H4C; TMEM147; FAM9A; SLU7; H3F3A; ZFPL1; POC1B; PTPRS; RPS25
Function protein binding, bridging
Related Protein FKBP4; GOLGA5; TRIM22; IVL; SYNM; FGA; ST13; FGG; ANXA1; LOR
Function protein complex scaffold
Related Protein MAGI1B; DLG1; GNB2L1; SLC9A3R1; ISCU; CAPN3; ARRB2; CAV1; AXIN1; CNOT1
Function protein phosphatase 2B binding
Related Protein BAD; AKAP1; SOD1; AKAP5; SLC9A1; MYOZ2; ATP2B4; PPP3CB
Function sodium:proton antiporter activity
Related Protein SLC9A7; SLC9A6B; SLC9A6A; SLC9A3; SLC9A1; SLC9A8; SLC9A9; SLC9A4; SLC9A3.2; SLC9A5
Function sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential
Related Protein SLC9A1
Function solute:proton antiporter activity
Related Protein SLC9A4; SLC9A6A; SLC9A6B; TMCO3; NHEDC1; SLC9A10; SLC9A3.1; SLC9A5; SLC9A3.2; SLC9B2

Interacting Protein

SLC9A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC9A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC9A1.
YWHAB; MAP3K7; CHP2; MAP4K4; UBE2I; MDFI; Rab5c; YWHAZ; Gbf1; Taf15; AP4S1; Mad2l1