• Official Full Name
  • synuclein, alpha interacting protein
  • Background
  • Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1.
  • Synonyms
  • SNCAIP; synuclein, alpha interacting protein; Sph1; SYPH1; MGC39814; synphilin-1; OTTHUMP00000159162; OTTHUMP00000159163; OTTHUMP00000222988; alpha-synuclein-interacting protein; synphilin
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SNCAIP, GST-tagged
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Sncaip protein, His & GST-tagged
Source (Host):Species:Human
Product nameRecombinant Human SNCAIP 293 Cell Lysate

Involved Pathway

SNCAIP involved in several pathways and played different roles in them. We selected most pathways SNCAIP participated on our site, such as Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with SNCAIP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Parkinsons disease

Protein Function

SNCAIP has several biochemical functions, for example, identical protein binding, protein binding, ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SNCAIP itself. We selected most functions SNCAIP had, and list some proteins which have the same functions with SNCAIP. You can find most of the proteins on our site.
Related Protein
Function identical protein binding
Related Protein CEP57L1; SH3GL2; APIP; DLC; RNF4; GRB7; TTN; BCL2L1; MRI1; MDM2
Function protein binding
Related Protein SOX13; ZNF544; NANOS3; PEX11G; EMP1; TMEM86B; FBXO11; SAMD4A; ADCYAP1R1; BTN3A1
Function ubiquitin protein ligase binding
Related Protein USP25; CUL3B; YOD1; SMAD2; UBE2U; RANGAP1; KCNQ3; UBE2H; RFFL; MOAP1

Interacting Protein

SNCAIP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNCAIP here. Most of them are supplied by our site. Hope this information will be useful for your research of SNCAIP.

SNCAIP Related Articles

Jeffries, MA; Donica, M; et al. Genome-Wide DNA Methylation Study Identifies Significant Epigenomic Changes in Osteoarthritic Cartilage. ARTHRITIS & RHEUMATOLOGY 66:2804-2815(2014).
Gylfe, AE; Kondelin, J; et al. Identification of Candidate Oncogenes in Human Colorectal Cancers With Microsatellite Instability. GASTROENTEROLOGY 145:540-+(2013).