top3a
Share
  • Official Full Name
  • topoisomerase (DNA) III alpha
  • Background
  • This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells.
  • Synonyms
  • TOP3A; topoisomerase (DNA) III alpha; TOP3; DNA topoisomerase 3-alpha; DNA topoisomerase 3 alpha; DNA topoisomerase III alpha; TOP 3; TOP3A_HUMAN; topoisomerase (DNA) III; topoisomerase III alpha; topo III-alpha; OTTHUMP00000065693
Cat.#:TOP3A-3352HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TOP3A, His-tagged
+Inquiry
Cat.#:TOP3A-8248HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TOP3A protein, His & T7-tagged
+Inquiry
Cat.#:TOP3A-17232MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TOP3A Protein
+Inquiry
Cat.#:TOP3A-2343CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TOP3A
+Inquiry
Cat.#:TOP3A-4584CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TOP3A
+Inquiry
Cat.#:TOP3A-4585CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TOP3A
+Inquiry
Cat.#:TOP3A-4586CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TOP3A
+Inquiry

Involved Pathway

TOP3A involved in several pathways and played different roles in them. We selected most pathways TOP3A participated on our site, such as Homologous recombination, Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TOP3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Homologous recombination
POLD2; BLM; RAD54L; TOP3B; SSBP1; RPA3; TOP3A; XRCC3; XRCC2; EME1
Fanconi anemia pathway
FANCM; USP36; ERCC4; USP1; FANCB; RPA3; ATRIP; STRA13; HES1; FUZ

Protein Function

TOP3A has several biochemical functions, for example, DNA binding, DNA topoisomerase type I activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TOP3A itself. We selected most functions TOP3A had, and list some proteins which have the same functions with TOP3A. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein ZBED4; ZBTB41; SAFB2; PPARD; NFIX; NEUROD4; HOXB9A; MB21D1; KDM2AA; ZBTB26
Function DNA topoisomerase type I activity
Related Protein TOP1L; TOP3B; TOP1; TOP1MT; TOP3A; CDK5R2
Function protein binding
Related Protein LAMA4; MICALL1; BMP7; MASP2; PENK; SUGT1; MPLKIP; CHAMP1; KCNH1; PPP2R5E
Function zinc ion binding
Related Protein MARCH9; CYHR1; PAPPA; RNF20; USP44; APOBEC1; PRKCA; PHF23A; KDM2BA; ING5A

Interacting Protein

TOP3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TOP3A here. Most of them are supplied by our site. Hope this information will be useful for your research of TOP3A.
BLM; RMI1; TERF2; RIF1; FANCA; ssdna_da; TP53

TOP3A Related Articles

Kim, HS; Cross, GAM; et al. Identification of Trypanosoma brucei RMI1/BLAP75 Homologue and Its Roles in Antigenic Variation. PLOS ONE 6:-(2011).
Chiappori, AA; Zheng, Z; et al. Features of Potentially Predictive Biomarkers of Chemotherapeutic Efficacy in Small Cell Lung Cancer. JOURNAL OF THORACIC ONCOLOGY 5:484-490(2010).