TP63 Protein, tumor protein p63

TP63

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TP63

Official Full Name tumor protein p63
Background This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined. [provided by RefSeq, Jul 2008]
Synonyms TP63; tumor protein p63; AIS; KET; LMS; NBP; RHS; p40; p51; p63; EEC3; OFC8; p73H; p73L; SHFM4; TP53L; TP73L; p53CP; TP53CP; B(p51A); B(p51B); tumor protein 63; CUSP; transformation-related protein 63; tumor protein p53-competing protein; amplified in squamous cell carcinoma; chronic ulcerative stomatitis protein; keratinocyte transcription factor KET; tumor protein p63 deltaN isoform delta;
    • Species :
    • Chicken
    • Human
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • DDK
    • GST
    • His
    • Myc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TP63-15H Recombinant Human TP63, His & GST-tagged Insect Cell His/GST
    Human TP63-2303H Recombinant Human TP63 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human TP63-30576TH Recombinant Human TP63 Insect Cell N/A
    Human TP63-327H Recombinant Human Tumor Protein P63, GST-tagged Sf9 Insect Cell GST
    Human TP63-32H Recombinant Human TP63 protein, DDK-tagged Insect Cell DDK
    Human TP63-3365H Recombinant Human TP63, GST-tagged E.coli GST
    Human TP63-472HCL Recombinant Human TP63 cell lysate Insect Cell N/A
    Human TP63-634H Recombinant Human TP63 Mammalian Cell His
    Human TP63-700H Recombinant Human Tumor Protein P63 E.coli N/A
    Rat TP63-6234R Recombinant Rat TP63 Protein Mammalian Cell His
    Chicken TP63-5923C Recombinant Chicken TP63 Mammalian Cell His
    Zebrafish TP63-9407Z Recombinant Zebrafish TP63 Mammalian Cell His

    TP63 involved in several pathways and played different roles in them. We selected most pathways TP63 participated on our site, such as MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with TP63 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MicroRNAs in cancer UBE2I; CCNE2; NFKB1; HRAS; BRCA1; PDGFB; ITGA5; EFNA3; Casp3; PTEN

    TP63 has several biochemical functions, for example, DNA binding, WW domain binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TP63 itself. We selected most functions TP63 had, and list some proteins which have the same functions with TP63. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding NR6A1B; PRDM10; ZNF230; FOSB; NFRKB; SP9; TFDP1B; WRN; GZF1; TRP53
    WW domain binding SCNN1B; TNK2; TRAF4; KIF20B; ATCAY; NDFIP2; DAZAP2; TMEM128; CDC25C; PPARG
    chromatin binding HDAC7A; PRDM13; TRP63; JUN; EBF2; HMGB3; BCL6; DNMT3B; COQ7; TSHZ3
    damaged DNA binding H2AFX; CRY2; NEIL3; BRCA1; MGMT; CRY-DASH; RBBP8; PCNA; MPG; APEX1
    double-stranded DNA binding TRP63; MTERF3; XRCC6; APTX; TDG; HNRPDL; TP63; TP73; HMGB1; FEV
    identical protein binding LRRK1; SH2B2; TLR3; GOT1; DVL1; PNMA5; DNMT3A; TRADD; DDX58; STAT2
    metal ion binding TRMT1; GTF3AB; ZC3H3; FTR50; PGGT1B; ZBTB1; CHORDC1; ZNF688; SNAI2; NTHL1
    p53 binding RNF34; MSX1; TAF3; EP300; TRP53; TRIM24; USP10; EHMT1; TP53BP1; NUAK1
    protein binding MAP2K5; BCAM; DUSP19; CRYBA4; ATXN3; DCTN2; TRIB3; KCTD5; CFI; ASB2
    sequence-specific DNA binding BATF; CDX1B; HOXA13; MAFG; SCAND2P; RARGB; MEOX2B; HOXB8; LBX1B; ESX1
    transcription factor activity, sequence-specific DNA binding HER5; FOXG1B; CIR1; PHF1; CITED2; TBX4; POU3F3; FOXG1C; FOXO3A; TBR1
    transcription factor activity, transcription factor binding HIF1A; PER2; LDB2A; TRP63; LDB2B; CRY2; CRY1; ASCL1B; LDB1B; MTA2
    transcription regulatory region DNA binding HNF1A; ZFP161; ASH2L; TAF2; GABPB1; CARM1; HMGB2; YAP1; FOXM1; BCL11B
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RFX4; TCF21; CREB1; EBF1; PLSCR1; CAMTA2; HEYL; HOXC13; FOXJ1; PATZ1

    TP63 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TP63 here. Most of them are supplied by our site. Hope this information will be useful for your research of TP63.

    TP53; SMAD2; PPP1R13B; NIPSNAP3A; SATB2; SYNCRIP; FUS; YAP1; HNRNPK

    Canham, M; Charsou, C; et al. Increased Cycling Cell Numbers and Stem Cell Associated Proteins as Potential Biomarkers for High Grade Human Papillomavirus plus ve Pre-Neoplastic Cervical Disease. PLOS ONE 9:-(2014).
    Kim, SK; Jung, WH; et al. p40 (Delta Np63) expression in breast disease and its correlation with p63 immunohistochemistry. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 7:1032-1041(2014).

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