tp63
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  • Official Full Name
  • tumor protein p63
  • Background
  • This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined. [provided by RefSeq, Jul 2008]
  • Synonyms
  • TP63; tumor protein p63; AIS; KET; LMS; NBP; RHS; p40; p51; p63; EEC3; OFC8; p73H; p73L; SHFM4; TP53L; TP73L; p53CP; TP53CP; B(p51A); B(p51B); tumor protein 63; CUSP; transformation-related protein 63; tumor protein p53-competing protein; amplified in squamous cell carcinoma; chronic ulcerative stomatitis protein; keratinocyte transcription factor KET; tumor protein p63 deltaN isoform delta;
Cat.#:TP63-2303HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TP63 Protein, MYC/DDK-tagged
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Cat.#:TP63-15HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TP63, His & GST-tagged
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Cat.#:TP63-30576THTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TP63
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Cat.#:TP63-32HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human TP63 protein, DDK-tagged
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Cat.#:TP63-3365HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TP63, GST-tagged
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Cat.#:TP63-634HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human TP63
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Cat.#:TP63-6234RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TP63 Protein
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Cat.#:TP63-5923CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TP63
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Cat.#:TP63-9407ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TP63
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Cat.#:TP63-700HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tumor Protein P63
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Cat.#:TP63-327HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Tumor Protein P63, GST-tagged
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Cat.#:TP63-472HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TP63 cell lysate
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Involved Pathway

TP63 involved in several pathways and played different roles in them. We selected most pathways TP63 participated on our site, such as MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with TP63 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MicroRNAs in cancer
TNXB; EZR; ROCK1; ST14; HMGA2; NFKB1; TRP53; PDGFA; CDC25A; PRKCG

Protein Function

TP63 has several biochemical functions, for example, DNA binding, WW domain binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TP63 itself. We selected most functions TP63 had, and list some proteins which have the same functions with TP63. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein TAF1D; UBN1; HISTH1L; SNAPC4; RXRBB; LBR; MBD3B; ENG2A; ESRRA; EEPD1
Function WW domain binding
Related Protein TRAF4; WBP5; DNM2; KIF20B; SCNN1G; TP63; DAZAP2; TMEM128; SHISA5; SCNN1B
Function chromatin binding
Related Protein TMPOA; EBF2; FANCM; NPM2; ARNTL1B; POLG; MAZ; KDM5A; KLF6A; SOX14
Function damaged DNA binding
Related Protein TP73; FANCG; BRCA1; MPG; HMGB2; RAD1; RPA2; RAD23A; POLB; POLD1
Function double-stranded DNA binding
Related Protein DDX11; HLF; CGGBP1; HNRPDL; RAD51; RAD51B; NTHL1; TARDBP; PIN4; GTF2H4
Function identical protein binding
Related Protein FZD1; S100A2; GNPNAT1; KCNJ2; CDC42; ATL1; EPHA4; FADD; DHX8; PYCARD
Function metal ion binding
Related Protein ADH8B; ZC3H14; COX4I2; Scd2; ZFP609; MFNG; B3GAT1; GGPS1; SPON2; ATP1A4
Function p53 binding
Related Protein SIRT1; HTT; CREBBP; RNF20; BCL2L12; ZNF385A; RNF34; TP73; ZNF385D; TP53
Function protein binding
Related Protein TNFRSF6B; ZBTB6; RAB6A; PDGFA; ABHD14B; ALPI; PDE2A; C22orf13; PAIP2; BARHL2
Function sequence-specific DNA binding
Related Protein ESRRA; TFAP4; NR2F2; RAG1; HOXD4; RX1; FOXF2; FOXF2A; NR2C2; TCF7L1A
Function transcription factor activity, sequence-specific DNA binding
Related Protein ATOH8; HOXB2A; TFAP2B; DEAF1; PBX1B; HOXD3A; ZNF396; TSC22D3; ZFP27; PHF1
Function transcription factor activity, transcription factor binding
Related Protein PER1; LDB2B; LDB2A; HIF1A; CRY1; CRY2; PER2; TRP63; FOXO1; TP63
Function transcription regulatory region DNA binding
Related Protein SALL1A; ATF5; ZBTB14; PRDM5; SALL3B; MZF1; TRP53; PPARG; EGR2; YY1
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein SOX1; CTCFL; SIX1; MYBL1; FOXA1; ONECUTL; ONECUT2; MYC; SFPI1; GLI2

Interacting Protein

TP63 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TP63 here. Most of them are supplied by our site. Hope this information will be useful for your research of TP63.
TP53; SMAD2; PPP1R13B; NIPSNAP3A; SATB2; SYNCRIP; FUS; YAP1; HNRNPK

TP63 Related Articles

Canham, M; Charsou, C; et al. Increased Cycling Cell Numbers and Stem Cell Associated Proteins as Potential Biomarkers for High Grade Human Papillomavirus plus ve Pre-Neoplastic Cervical Disease. PLOS ONE 9:-(2014).
Kim, SK; Jung, WH; et al. p40 (Delta Np63) expression in breast disease and its correlation with p63 immunohistochemistry. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 7:1032-1041(2014).