trim25
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  • Official Full Name
  • tripartite motif containing 25
  • Background
  • TRIM25, also known as estrogen responsive finger protein (EFP) is a member of the RING finger-B box-coiled coil family, and functions as a ubiquitin ligase. Mice lacking this gene displayed an underdeveloped uterus and reduced estrogen responsiveness demo
  • Synonyms
  • TRIM25; tripartite motif containing 25; tripartite motif containing 25 , zinc finger protein 147 (estrogen responsive finger protein) , ZNF147; E3 ubiquitin/ISG15 ligase TRIM25; EFP; RNF147; RING finger protein 147; zinc finger protein-147; tripartite mo
Cat.#:TRIM25-17350MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TRIM25 Protein
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Cat.#:TRIM25-10521ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TRIM25
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Cat.#:TRIM25-788HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TRIM25 293 Cell Lysate
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Involved Pathway

TRIM25 involved in several pathways and played different roles in them. We selected most pathways TRIM25 participated on our site, such as NF-kappa B signaling pathway, RIG-I-like receptor signaling pathway, Influenza A, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM25 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
NF-kappa B signaling pathway
LTBR; VCAM1; CCL19; TNFRSF1A; TRAF6; MAP3K7IP3; TRAF1; RELA; CCL21; LBP
RIG-I-like receptor signaling pathway
IL8L2; RELA; AZI2; TRADD; CXCL8B.3; MAPK10; IFNK; PL10; IFNA17; NLRX1
Influenza A
SOCS3; IFNAR2; BLA; STAT2; RAF1; STAT1; H2-AA; PABPN1; HLA-DQA2; PIK3R2

Protein Function

TRIM25 has several biochemical functions, for example, acid-amino acid ligase activity, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM25 itself. We selected most functions TRIM25 had, and list some proteins which have the same functions with TRIM25. You can find most of the proteins on our site.
Function
Related Protein
Function acid-amino acid ligase activity
Related Protein RNF41; TRIM25; UBA3; RAG1
Function poly(A) RNA binding
Related Protein TRMT6; AGO1; EIF3A; ZCCHC7; ROCK2; RPL35A; FAU; DHX16; EZR; EIF5B
Function protein binding
Related Protein EPHB4; NUMB; TBCA; MAP4K1; FAM120B; NOLC1; LAGE3; RPS19BP1; MYL2; SORL1
Function transcription factor activity, sequence-specific DNA binding
Related Protein ZNF383; FUBP1; HNF1BB; TADA2A; TBP; EFCAB11; SOX3; NPAS1; BUD31; ELF2A
Function ubiquitin protein ligase activity involved in ERAD pathway
Related Protein AMFR; TMEM129; RNF185; RNF5; PARK2; SYVN1; STUB1; TRIM25
Function zinc ion binding
Related Protein FBXO40.1; MT3; MMP13A; KAT6B; CNBPA; RASGRP1; SLC25A46; NSMCE2; RNF181; ZCCHC4

Interacting Protein

TRIM25 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM25 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM25.
DDX58; NS; f1ba49_9viru; NS1; NS1; NS1; NS1; XRCC3; IGF1R; APC