trim69
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  • Official Full Name
  • tripartite motif containing 69
  • Background
  • This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.
  • Synonyms
  • TRIM69; tripartite motif containing 69; ring finger protein 36 , RNF36, tripartite motif containing 69; tripartite motif-containing protein 69; Trif; TRIMLESS; HSD34; RFP like domain containing protein trimless; RFP-like domain-containing protein trimless; RING finger protein 36; RNF36; TRI69_HUMAN; tripartite motif containing protein 69; tripartite motif protein 69; tripartite motif-containing 69
Cat.#:TRIM69-2653HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TRIM69 Protein, MYC/DDK-tagged
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Cat.#:TRIM69-17395MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TRIM69 Protein
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Cat.#:TRIM69-6284RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TRIM69 Protein
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Cat.#:TRIM69-8493ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TRIM69
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Cat.#:TRIM69-1528HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TRIM69 cell lysate
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Involved Pathway

TRIM69 involved in several pathways and played different roles in them. We selected most pathways TRIM69 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM69 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
FRS2; OSBPL1A; CDKN1A; CTSL1; DYNC1LI2; ASB7; KIF5A; TRIM11; KLHL20; LILRA3
Antigen processing: Ubiquitination &
SPSB2; BLMH; ASB14; SH3RF1; UBE2F; MKRN1; RNF123; ASB18; DTX3L; PJA2
Proteasome degradation
HECTD3; UBE2E3; GAN; ASB2; RNF123; TPP2; UFL1; RNF220; UBE2L6; NPEPPS
Class I MHC mediated antigen processing &
TRIM41; PJA2; RNF4; SEC24A; RNF123; CYBA; ASB13; ASB2; UBE2L6; UBE2F
presentation
UBE2U; ERAP1; RNF41; TRIM69; UBE2L6; PJA2; ASB3; ASB2; LRRC41; CMTM2A
Immune System
OASL; TRIM8; DEFB1; AGER; CD300E; POLR3H; HUWE1; SPSB2; DEFB125; KIF20A

Protein Function

TRIM69 has several biochemical functions, for example, ligase activity, protein binding, ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM69 itself. We selected most functions TRIM69 had, and list some proteins which have the same functions with TRIM69. You can find most of the proteins on our site.
Function
Related Protein
Function ligase activity
Related Protein UBE3B; RNF25; COP1; RNF13; ZSWIM2; MID1; TRIM33; RNF217; UBE2L3B; MGRN1A
Function protein binding
Related Protein IGF2BP3; DDIT3; ASAP1; COPG; CLN5; PAIP1; FOXK1; MUL1; CD4; RAD18
Function ubiquitin-protein transferase activity
Related Protein RNF139; TNFAIP3; RAG1; BIRC2; SIAH1; UBE2G1; NHLRC1; CDC23; TRIM33; RNF187
Function zinc ion binding
Related Protein MORC2; MATR3; TET2; CA8; MT1H; KIAA0913; TRIM42; ZFAND5B; RFFL; TRIM28

Interacting Protein

TRIM69 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM69 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM69.
KRT17; ATP5G1; ASNS; FKBP1B; SF3A3; SF1; MAGEA4

TRIM69 Related Articles

Getachew, P; Hannan, MA; et al. Induced changes in the proteomic profile of the phaeophyte Saccharina japonica upon colonization by the bryozoan Membranipora membranacea. JOURNAL OF APPLIED PHYCOLOGY 26:657-664(2014).
Zoumpoulidou, G; Broceno, C; et al. Role of the Tripartite Motif Protein 27 in Cancer Development. JOURNAL OF THE NATIONAL CANCER INSTITUTE 104:941-952(2012).
Altmann, SM; Mellon, MT; et al. Cloning and characterization of an Mx gene and its corresponding promoter from the zebrafish, Danio rerio. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 28:295-306(2004).