trpc3
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  • Official Full Name
  • transient receptor potential cation channel, subfamily C, member 3
  • Background
  • The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
  • Synonyms
  • TRPC3; transient receptor potential cation channel, subfamily C, member 3; TRP3; short transient receptor potential channel 3; hTrp-3; transient receptor protein 3; transient receptor potential cation channel subfamily C member 3 variant c;
Cat.#:TRPC3-4609CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TRPC3
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Cat.#:TRPC3-8414ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TRPC3
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Cat.#:TRPC3-745HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human TRPC3 293 Cell Lysate
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Involved Pathway

TRPC3 involved in several pathways and played different roles in them. We selected most pathways TRPC3 participated on our site, such as Axon guidance, Developmental Biology, Effects of PIP2 hydrolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRPC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
EFNA1B; ACTR2B; SLC14A2; DUSP4; CSF2RA; SEMA5A; CD24; DNM2; SRGAP3; Plxna2
Developmental Biology
SCN8A; NRTN; SPTA1; ARPC2; MYOD1; EFNA3; ARPC1A; RASGRP1; NR6A1; DNM1
Effects of PIP2 hydrolysis
DGKA; ABHD12; DGKB; TAE1; TRPC7; MGLL; TRPC6A; DGKQ; ABHD6B; RASGRP2
Elevation of cytosolic Ca2+ levels
TRPC3; TRPC7; TRPC6A
G alpha (q) signalling events
OPN4A; OPN4B; EDNRB; NPFF; LPAR5A; LPAR1; ANXA1A; GRP; DGKG; PMCH
GPCR downstream signaling
HRH3; ADRA2C; TAS2R16; CCR7; RXFP2; ADRA2B; CCL19A.2; DRD3; CGA; OPN1LW2
Gastrin-CREB signalling pathway via PKC and MAPK
GPR65; NMBB; DGKA; FPR-RS6; ANXA1; OPN4B; LPAR1; RGS18; OPN4; CCK
Hemostasis
PDPN; CD9A; APOBB.1; GRB14; D-AKAP2; KIF18A; SLC8A2A; HBB-BH1; AKAP10; F13A1A.1

Protein Function

TRPC3 has several biochemical functions, for example, calcium channel activity, inositol 1,4,5 trisphosphate binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRPC3 itself. We selected most functions TRPC3 had, and list some proteins which have the same functions with TRPC3. You can find most of the proteins on our site.
Function
Related Protein
Function calcium channel activity
Related Protein TRPC5; PKD2L2; ITPR3; SLC24A1; TRPM8; PDE2A; TRPN1; TRPC7B; CACNG7A; CHRNA9
Function inositol 1,4,5 trisphosphate binding
Related Protein TRPC6A; AKR1C1; TRPC7; PLCL1; TRPC7A; TRPC2B; CYTH2; TRPC3; ITPR3; TRPC5A
Function protein binding
Related Protein POLA1; TGFBRAP1; ANXA6; CLU; UBD; ZFP259; HSPB2; HIST1H1E; CENPO; ELMOD3
Function store-operated calcium channel activity
Related Protein TRPC3; STIM2; TRPC6; ORAI2; TRPC1; TRPC5; TRPC2B; ORAI1; ZP3; TRPC7A

Interacting Protein

TRPC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRPC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRPC3.
ITPR3; MX1; Plcg1

TRPC3 Related Articles

Xie, YF; Zhou, FM; et al. TRPC3 channel mediates excitation of striatal cholinergic interneurons. NEUROLOGICAL SCIENCES 35:1757-1761(2014).
Zhou, FW; Roper, SN; et al. TRPC3 mediates hyperexcitability and epileptiform activity in immature cortex and experimental cortical dysplasia. JOURNAL OF NEUROPHYSIOLOGY 111:1227-1237(2014).