trpm6
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  • Official Full Name
  • transient receptor potential cation channel, subfamily M, member 6
  • Background
  • TRPM6 is a transient receptor potential ion channel associated with hypomagnesemia with secondary hypocalcemia.
  • Synonyms
  • TRPM6; transient receptor potential cation channel, subfamily M, member 6; HOMG, HSH, hypomagnesemia, secondary hypocalcemia; transient receptor potential cation channel subfamily M member 6; CHAK2; FLJ22628; channel kinase 2; melastatin-related TRP cati
Cat.#:TRPM6-824HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human TRPM6
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Cat.#:TRPM6-8098ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TRPM6
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Involved Pathway

TRPM6 involved in several pathways and played different roles in them. We selected most pathways TRPM6 participated on our site, such as Ion channel transport, Mineral absorption, Stimuli-sensing channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRPM6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ion channel transport
CLCN2; TRPA1B; SRI; ARHGEF9; GLRBA; TRPA1A; BEST1; PDZD11; CLCN7; ATP8B1
Mineral absorption
ATOX1; MT1B; MT1F; FTL; STEAP2; MT1G; ATP1B1; SLC34A2; HMOX2; FTH1
Stimuli-sensing channels
CLCN4; ANO1; ANO10A; CLCNK; SGK2; TRPC5A; TPCN1; WNK2; TTYH3; ANO6
TRP channels
TRPM1A; TRPM4C; TRPM4A; TRPC4B; TRPC4A; TRPA1B; TRPC4; TRPC4APA; TRPA1A; MCOLN3
Transmembrane transport of small molecules
SLC35A1; WNK2; ASIC1A; PIP; NIPA1; SLC28A3; SLC7A6; SLC30A6; SLC6A19B; SLCO2B1

Protein Function

TRPM6 has several biochemical functions, for example, ATP binding, calcium channel activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRPM6 itself. We selected most functions TRPM6 had, and list some proteins which have the same functions with TRPM6. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein CDK3; PRKCQ; TAP2; CAMKK1; MAP3K5; TRPM6; TSSK2; NME4; SGK2; DDX3Y
Function calcium channel activity
Related Protein TMEM37; CACNG2A; TRPV2; TRPC4B; CHRNA9; P2RX1; MCU; TRPC2B; TPCN1; CACFD1
Function metal ion binding
Related Protein TRIM59; ATP1A1A.1; PLCD3; TRIM46B; ZNF483; SCD5; PARP12A; SMYD2; ZSCAN12; SCNM1-PS
Function protein binding
Related Protein NUDT4; SUSD2; MAPK7; SYVN1; GP1BB; AZIN1; ODF1; TIMM10; DTNA; BACE1
Function protein serine/threonine kinase activity
Related Protein PAK4; TGFBR1; ULK1; NEK3; STK35L; KALRN; MAPK8A; LATS2; CLK3; STK4

Interacting Protein

TRPM6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRPM6 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRPM6.
MYH9; MYH10; MYH14

TRPM6 Related Articles

Costa, A; Tejpar, S; et al. Hypomagnesaemia and targeted anti-epidermal growth factor receptor (EGFR) agents. TARGETED ONCOLOGY 6:227-233(2011).
Dimke, H; van der Wijst, J; et al. Effects of the EGFR Inhibitor Erlotinib on Magnesium Handling. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 21:1309-1316(2010).