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TRPV5

  • Official Full Name

    transient receptor potential cation channel, subfamily V, member 5

  • Overview

    This gene is a member of the transient receptor family and the TrpV subfamily. The calcium-selective channel encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level. [provided by RefSeq, Jul 2008]
  • Synonyms

    TRPV5; transient receptor potential cation channel, subfamily V, member 5; CAT2; ECAC1; OTRPC3; transient receptor potential cation channel subfamily V member 5; ECaC; calcium transporter 2; osm-9-like TRP channel 3; calcium transport protein 2; epithelial calcium channel 1;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Oryctolagus cuniculus (Rabbit)
  • Rat
  • Rattus norvegicus (Rat)
  • E. coli
  • E.coli
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Flag
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TRPV5-630H Recombinant Human TRPV5 protein, His-tagged E. coli His 1-331 aa
Human TRPV5-6012H Recombinant Human TRPV5 Protein (Met1-Pro327), N-His tagged E.coli N-His Met1-Pro327
Human TRPV5-1178HFL Recombinant Human TRPV5 protein, His&Flag-tagged HEK293 His&Flag 1-729 aa
Mouse TRPV5-17464M Recombinant Mouse TRPV5 Protein Mammalian Cell His
Mouse TRPV5-9662M Recombinant Mouse TRPV5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse TRPV5-9662M-B Recombinant Mouse TRPV5 Protein Pre-coupled Magnetic Beads HEK293
Rat TRPV5-6306R Recombinant Rat TRPV5 Protein Mammalian Cell His
Rat TRPV5-5963R Recombinant Rat TRPV5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat TRPV5-5963R-B Recombinant Rat TRPV5 Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL10048HF Recombinant Full Length Human Transient Receptor Potential Cation Channel Subfamily V Member 5(Trpv5) Protein, His-Tagged E.coli expression system His Full Length (1-729)
Oryctolagus cuniculus (Rabbit) RFL34963OF Recombinant Full Length Rabbit Transient Receptor Potential Cation Channel Subfamily V Member 5(Trpv5) Protein, His-Tagged E.coli expression system His Full Length (1-730)
Rattus norvegicus (Rat) RFL17023RF Recombinant Full Length Rat Transient Receptor Potential Cation Channel Subfamily V Member 5(Trpv5) Protein, His-Tagged E.coli expression system His Full Length (1-723)
  • Involved Pathway
  • Protein Function
  • Interacting Protein

TRPV5 involved in several pathways and played different roles in them. We selected most pathways TRPV5 participated on our site, such as Endocrine and other factor-regulated calcium reabsorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRPV5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Endocrine and other factor-regulated calcium reabsorptionPRKACG;PRKCG;PLCB3;RAB11A;KLK2;KLK1;PLCB1;ATP1A1;VDR

TRPV5 has several biochemical functions, for example, calcium channel activity, calmodulin binding, ion channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRPV5 itself. We selected most functions TRPV5 had, and list some proteins which have the same functions with TRPV5. You can find most of the proteins on our site.

Function Related Protein
calcium channel activityTRPV1;PKD2L1;PDE2A;UBXN6;MCU;CACNG8A;ITPR3;TMEM37;CACFD1
calmodulin bindingCAMSAP1L1;INVS;RIT2;PHKB;STRN4;SPATA17;EWSR1;MAPKAPK2;TRPC2
ion channel activityCLCNKB;RYR1B;CHRNB3B;KCNC1A;SCN1LAB;GJC1;TRPM1A;ASIC4;TRPM1B
protein bindingVRK1;CACNB4;ALOX12B;MIER1;LNX2;HELT;IL-8;TRIM55;HDDC3

TRPV5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRPV5 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRPV5.

Wnk4; Slc9a3r2

  • Q&As
  • Reviews

Q&As (7)

Ask a question
How does TRPV5 interact with other ion channels in the renal system? 08/16/2021

TRPV5 coordinates with renal ion channels for calcium handling.

How do genetic variations in TRPV5 affect calcium regulation? 07/29/2020

Genetic mutations in TRPV5 can affect bone density and mineral balance.

What is the primary role of TRPV5 in mineral homeostasis? 07/28/2020

TRPV5 is key in maintaining calcium balance in the body.

What potential therapeutic applications arise from targeting TRPV5 in calcium-related disorders? 05/11/2020

Targeting TRPV5 could treat osteoporosis and prevent kidney stones.

How does TRPV5 contribute to calcium absorption in the kidneys? 05/24/2018

It facilitates calcium reabsorption in the kidneys.

What role does TRPV5 play in bone metabolism? 11/03/2017

TRPV5 influences calcium availability for bone health.

What is the impact of altered TRPV5 activity on kidney function? 05/05/2017

Altered TRPV5 activity can contribute to kidney stones and renal disorders.

Customer Reviews (3)

Write a review
Reviews
01/09/2022

    Expertise shines, crucial for our research success.

    06/09/2019

      Exceptional accuracy, enhances our research outcomes.

      03/29/2017

        Timely delivery, invaluable for our experiments.

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