ubr2
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  • Official Full Name
  • Ubiquitin protein ligase E3 component n-recognin 2
  • Background
  • Proteolysis by the ubiquitin-proteasome system controls the concentration of many regulatory proteins. The selectivity of ubiquitylation is determined by ubiquitin E3 ligases, which recognize the substrate's destabilization signal, or degron. The E3 ligase UBR2 participates in the N-end rule pathway, which targets proteins bearing an N-terminal degron, or N-degron (Kwon et al., 2003 [PubMed 14585983]).[supplied by OMIM]
  • Synonyms
  • UBR2;Ubiquitin protein ligase E3 component n-recognin 2;Rabbit;Human;Rabbit Anti-Human UBR2 Polyclonal Antibody;Rabbit Anti-Human UBR2;Polyclonal Antibody;Rabbit Anti-Human UBR2 Antibody;Polyclonal;Rabbit Anti-Human UBR2 Polyclonal;Antibody;Rabbit Anti-Human Ubiquitin protein ligase E3 component n-recognin 2 Polyclonal;Rabbit Anti-Human Ubiquitin protein ligase E3 component n-recognin 2 Antibody;Anti-Human UBR2 Polyclonal;Anti-Human UBR2 Antibody;Anti-Human Ubiquitin protein ligase E3 component n-recognin 2 Polyclonal;Anti-Human Ubiquitin protein ligase E3 component n-recognin 2 Antibody;Anti-Human UBR2;Anti-UBR2;Anti-Human Ubiquitin protein ligase E3 component n-recognin 2;Anti-Ubiquitin protein ligase E3 component n-recognin 2;
Cat.#:UBR2-3561HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBR2, GST-tagged
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Cat.#:UBR2-1876HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human UBR2 cell lysate
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Involved Pathway

UBR2 involved in several pathways and played different roles in them. We selected most pathways UBR2 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
LTN1; AP2B1; PDPK1A; GM11711; ASB9; SIGLEC11; Mill2; CYBB; DYNLL2; MGC174152
Antigen processing: Ubiquitination &
UBE2U; SH3RF1; ASB17; ARIH2; RNF138; LRSAM1; TRAF7; MKRN1; FBXO27; DTX3L
Proteasome degradation
UBE2F; ATG7; UBE2L6; STUB1; TPP2; ASB3; ASB14; TRIM41; ASB8; LRR1
Class I MHC mediated antigen processing &
TRIM11; KLHL20; SPSB1; ASB10; TRIM39; RBCK1; RNF220; CD207; CYBA; TPP2
presentation
ASB3; CYBB; RBCK1; RNF34; TRIM39; KLHL21; RNF144B; CTSS; RNF41; UBE2J2
Immune System
IFI35; SIRPB1; TRIM45; GBP1; KIF26A; KIF4; KPNA5; CD300C; GRAP2A; DYNC1LI2

Protein Function

UBR2 has several biochemical functions, for example, leucine binding, ligase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBR2 itself. We selected most functions UBR2 had, and list some proteins which have the same functions with UBR2. You can find most of the proteins on our site.
Function
Related Protein
Function leucine binding
Related Protein UBR1; GLUD1; GLUD2; UBR2
Function ligase activity
Related Protein UHRF1; UBE3B; PIAS2; ACSF2; BARD1; ZFP91; UBR4; TRIM68; PDZRN3; TRAF7
Function protein binding
Related Protein PYCRL; WIPF2; MMP2; RAD52; NFATC1; ANKRD24; LRP1; FUNDC1; MED25; TRAF3IP2
Function ubiquitin protein ligase activity
Related Protein UBE2Z; UHRF1; UBE2NB; RNF144A; UBE2W; RNF41; C12orf51; RNF144AA; HERC3; NHLRC1
Function zinc ion binding
Related Protein VPS41; MTA1; ESRRGB; ISL1L; ADAM10B; ZIM2; CPXM1; NR5A1A; CPA6; ZDHHC15B

Interacting Protein

UBR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBR2.
vif; Ttll7; UBXN7; MYC; NES; TIRAP; Dynlrb1; UBXN1; Naa11; SGOL1; MRPL50; FAF2; Cdc26; PARD6B; FAF1