ulk2
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  • Official Full Name
  • unc-51-like kinase 2 (C. elegans)
  • Background
  • This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified.
  • Synonyms
  • ULK2; unc-51-like kinase 2 (C. elegans); unc 51 (C. elegans) like kinase 2; serine/threonine-protein kinase ULK2; ATG1B; KIAA0623; Unc51.2; Serine/threonine protein kinase ULK2; ULK2_HUMAN; Unc 51 like kinase 2; Unc-51-like kinase 2; OTTHUMP00000065847; OTTHUMP00000065848
Cat.#:ULK2-456HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human ULK2 protein, GST-tagged
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Cat.#:ULK2-1115HTag:GST
Source (Host):Sf 10 Insect cellsSpecies:Human
Product nameRecombinant Human Unc-51-Like Kinase 2 (C. elegans), GST-tagged
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Cat.#:ULK2-504HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ULK2 293 Cell Lysate
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Involved Pathway

ULK2 involved in several pathways and played different roles in them. We selected most pathways ULK2 participated on our site, such as Regulation of autophagy, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ULK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Regulation of autophagy
ATG12; ATG4C; IFNA1; GABARAPA; ATG7; ATG5; ATG4B; PRKAA2; ULK1; IFNA12
mTOR signaling pathway
RPTOR; MAPK1; EIF4BB; IRS1; RPS6; RHEB; CAB39L; RPS6KB1; RRAGD; AKT2

Protein Function

ULK2 has several biochemical functions, for example, ATP binding, protein binding, protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ULK2 itself. We selected most functions ULK2 had, and list some proteins which have the same functions with ULK2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein NME2; DDX39B; BMPR1A; RECQL; IPMK; PRPS1L1; SGK2B; TSSK3; MYO1H; RPS6KB2
Function protein binding
Related Protein SNTB2; PEX1; ASIC1; LAMP1; HOXA9; CD37; FOXN3; SNRNP40; AZU1; GOPC
Function protein serine/threonine kinase activity
Related Protein ACVR2AA; SMOK3A; CSNK2A1; PIM1; TAOK1; MAP2K6; MAP3K2; STK32B; ERN1; PSKH2

Interacting Protein

ULK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ULK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ULK2.
RB1CC1; GABARAP; IRF1; GABARAPL2; MAP1LC3B; GABARAPL1; ZNF32; EEF1B2; NASP; POLA2; SETDB1; DIXDC1; LNX1; LUC7L2; PRKAB2

ULK2 Related Articles

Huang, YH; Huang, XH; et al. Involvement of fish signal transducer and activator of transcription 3 (STAT3) in nodavirus infection induced cell death. FISH & SHELLFISH IMMUNOLOGY 43:241-248(2015).
Lee, S; Page-McCaw, P; et al. Kctd12 and Ulk2 Partner to Regulate Dendritogenesis and Behavior in the Habenular Nuclei (vol 9, e110280, 2014). PLOS ONE 10:-(2015).