unc13a
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  • Official Full Name
  • unc-13 homolog A
  • Background
  • This gene encodes a member of the UNC13 family. UNC13 proteins bind to phorbol esters and diacylglycerol and play;important roles in neurotransmitter release at synapses. Single nucleotide polymorphisms in this gene may be;associated with sporadic amyotrophic lateral sclerosis.
  • Synonyms
  • UNC13A; unc-13 homolog A (C. elegans); protein unc-13 homolog A; KIAA1032; Munc13 1; Munc13-1
Cat.#:UNC13A-17840MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse UNC13A Protein
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Cat.#:UNC13A-6444RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat UNC13A Protein
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Involved Pathway

UNC13A involved in several pathways and played different roles in them. We selected most pathways UNC13A participated on our site, such as Synaptic vesicle cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with UNC13A were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Synaptic vesicle cycle
ATP6V1E1; NAPA; UNC13C; CPLX2; SNAP25; ATP6V0E2; SLC18A2; DNM3; SLC18A1; ATP6V1B1

Protein Function

UNC13A has several biochemical functions, for example, SNARE binding, diacylglycerol binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UNC13A itself. We selected most functions UNC13A had, and list some proteins which have the same functions with UNC13A. You can find most of the proteins on our site.
Function
Related Protein
Function SNARE binding
Related Protein STX3A; SEC22C; SEC22A; STX2A; VTI1B; ANKRD27; VAMP3; STX11A; SYBL1; CAPN10
Function diacylglycerol binding
Related Protein TRPC2; RASGRP1; UNC13B; RASGRP3; UNC13A; CDIPT; RASGRP4; RASGRP2; UNC13C
Function metal ion binding
Related Protein BRIP1; ZNF766; ZFP335; BSN; CA15A; ZNF649; DNMT3A; LHX6; CAR3; ERCC5
Function protein N-terminus binding
Related Protein MAP2K1; STX5; ERCC4; MECP2; SCT; SLA2; TRP53; TAF11; SLC6A3; UNC13A
Function protein binding
Related Protein LY6H; CST7; PIH1D3; ING2; SGIP1; YEATS4; TBC1D20; TCF7; ANK2; STAR
Function protein domain specific binding
Related Protein IPCEF1; Ar; CSNK2B; ARRB2; STRN4; STXBP1; PICK1; DYNLL1; TBL1X; HOXB1
Function protein heterodimerization activity
Related Protein PRSS28; HNF1A; KCNIP1; FZD9; AHR; ATF4; FLOT1; UGT1A4; SYT10; HIST1H2BK
Function protein homodimerization activity
Related Protein PLEK; SLC30A8; XDH; CECR1; GPD1B; Anks6; RAB11FIP3; FOXP2; GJC3; C1QB
Function spectrin binding
Related Protein SPTAN1; MYO10; UNC13A; CAMSAP1; EPB49; DYNC1I1; ADD1; USH1G; GNB1; KIF3A
Function syntaxin-1 binding
Related Protein STXBP1; SNPH; CPLX1; SNAP25B; SNAP25; GOLSYN; SNAP25A; LRRK2; DAPK1; SYT1

Interacting Protein

UNC13A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UNC13A here. Most of them are supplied by our site. Hope this information will be useful for your research of UNC13A.
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UNC13A Related Articles

Luo, T; Kuriakose, JA; et al. Ehrlichia chaffeensis TRP120 Interacts with a Diverse Array of Eukaryotic Proteins Involved in Transcription, Signaling, and Cytoskeleton Organization. INFECTION AND IMMUNITY 79:4382-4391(2011).
BROSE, N; HOFMANN, K; et al. MAMMALIAN HOMOLOGS OF CAENORHABDITIS-ELEGANS UNC-13 GENE DEFINE NOVEL FAMILY OF C-2-DOMAIN PROTEINS. JOURNAL OF BIOLOGICAL CHEMISTRY 270:25273-25280(1995).