UNC13A Protein, unc-13 homolog A

UNC13A

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UNC13A

Official Full Name unc-13 homolog A
Background This gene encodes a member of the UNC13 family. UNC13 proteins bind to phorbol esters and diacylglycerol and play;important roles in neurotransmitter release at synapses. Single nucleotide polymorphisms in this gene may be;associated with sporadic amyotrophic lateral sclerosis.
Synonyms UNC13A; unc-13 homolog A (C. elegans); protein unc-13 homolog A; KIAA1032; Munc13 1; Munc13-1
    • Species :
    • Mouse
    • Rat
    • Source :
    • Mammalian Cell
    • Tag :
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse UNC13A-17840M Recombinant Mouse UNC13A Protein Mammalian Cell His
    Rat UNC13A-6444R Recombinant Rat UNC13A Protein Mammalian Cell His

    UNC13A involved in several pathways and played different roles in them. We selected most pathways UNC13A participated on our site, such as Synaptic vesicle cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with UNC13A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Synaptic vesicle cycle ATP6V0E; ATP6V0B; SLC17A7; STX2; ATP6V0A2; SNAP25; NAPA; SYT1; SLC17A6; ATP6V1E2

    UNC13A has several biochemical functions, for example, SNARE binding, diacylglycerol binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UNC13A itself. We selected most functions UNC13A had, and list some proteins which have the same functions with UNC13A. You can find most of the proteins on our site.

    Function Related Protein
    SNARE binding VTI1A; VAMP2; SYT1; SEC22BA; STX1A; SEC22BB; STX7; NBAS; CCDC167; UVRAG
    diacylglycerol binding RASGRP1; UNC13B; UNC13A; CDIPT; RASGRP3; TRPC2; UNC13C; RASGRP2; RASGRP4
    metal ion binding ZFYVE28; ZC2HC1A; CD209C; ZFYVE27; ZNF839; TIMM8A2; RNF150; TRIM2A; CYP2P7; NEK11
    protein N-terminus binding KCNIP1; SCFD1; ATM; TP53; DCN; HAX1; CSNK2A2; SERPINB1A; NFE2; ARF6
    protein binding TRPV5; HSP90AA1.2; FBXO28; RAB43; DMAP1; DMC1; RAD9; NME2; VGLL4; ORAI2
    protein domain specific binding CEP68; ERCC1; PICK1; STAMBP; CHMP1B; ST13; CA; STMN3; SLC34A2; CNOT1
    protein heterodimerization activity SNX1; RRAGC; MAFGA; XBP1; TXLNG; H2AFY; BRAF; PRMT5; HIST1H2BH; GCLC
    protein homodimerization activity UGT1A7; SLIT2; MAPK4; UGT1A6; IKZF2; GNB2L1; BCL11A; ACVR1; CHUK; ARID3A
    spectrin binding ADD2; DYNC1I1; USH1C; MYO10; EPB49; UNC13A; MYO7A; PTPRN; SLC26A5; CAMSAP1L1
    syntaxin-1 binding VAMP3; MYO5A; SYBU; SNPH; STXBP3; RNF40; STXBP2; STXBP3A; CPLX1; CCDC167

    UNC13A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UNC13A here. Most of them are supplied by our site. Hope this information will be useful for your research of UNC13A.

    Ywhab

    Luo, T; Kuriakose, JA; et al. Ehrlichia chaffeensis TRP120 Interacts with a Diverse Array of Eukaryotic Proteins Involved in Transcription, Signaling, and Cytoskeleton Organization. INFECTION AND IMMUNITY 79:4382-4391(2011).
    BROSE, N; HOFMANN, K; et al. MAMMALIAN HOMOLOGS OF CAENORHABDITIS-ELEGANS UNC-13 GENE DEFINE NOVEL FAMILY OF C-2-DOMAIN PROTEINS. JOURNAL OF BIOLOGICAL CHEMISTRY 270:25273-25280(1995).

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