UNC13B Protein, unc-13 homolog B (C. elegans)


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Official Full Name unc-13 homolog B (C. elegans)
Background This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.
Synonyms UNC13B; unc-13 homolog B (C. elegans); unc 13 like (C. elegans) , UNC13; protein unc-13 homolog B; hmunc13; Unc13h2; MGC133279; MGC133280; munc13; Munc13-2; UN13B_HUMAN; UNC13; homolog of rat Munc13 (diacylglycerol-binding)
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • Mammalian Cell
    • Tag :
    • GST
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human UNC13B-3596H Recombinant Human UNC13B, GST-tagged E.coli GST
    Mouse UNC13B-17841M Recombinant Mouse UNC13B Protein Mammalian Cell His
    Rat UNC13B-6445R Recombinant Rat UNC13B Protein Mammalian Cell His

    UNC13B involved in several pathways and played different roles in them. We selected most pathways UNC13B participated on our site, such as Acetylcholine Neurotransmitter Release Cycle, Dopamine Neurotransmitter Release Cycle, Effects of Botulinum toxin, which may be useful for your reference. Also, other proteins which involved in the same pathway with UNC13B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Acetylcholine Neurotransmitter Release Cycle BZRAP1; UNC13B; STXBP1A; PPFIA4; CPLX1; CHAT; SNAP25B; PPFIA1; RERG; SLC18A3A
    Dopamine Neurotransmitter Release Cycle LIN7A; SYN1; Apba1; PPFIA4; CCDC167; SYN3; PPFIA1; LIN7C; RERG; UNC13B
    Effects of Botulinum toxin CHRNA1; CCDC167; UNC13B; RAB3GAP2
    Glutamate Neurotransmitter Release Cycle ARL6IP5A; CCDC167; CPLX2L; SYT1A; RAB3AA; UNC13B; BZRAP1; RAB3AB; CPLX1; SLC1A2A
    Monoamine Transport HRH3; FBXO32; UNC13B; DBH; SYN1; TGFB1I1; SCAMP2; TPH2
    Neuronal System KCNQ2A; SLC6A11; NSFA; LIN7A; KCNH1B; PPFIA4; KCNJ11; KCNA4; CACNG2B; KCNK3A
    Neurotransmitter Release Cycle SNAP25A; STXBP1A; PPFIA4; CPLX2L; SLC17A7A; RAB3AB; SNAP25B; SLC1A7A; LIN7B; SYT1A
    Norepinephrine Neurotransmitter Release Cycle SNAP25B; PPFIA2; RAB3AA; PPFIA1; SNAP25A; CPLX1; PPFIA4; STXBP1A; SYT1A; UNC13B

    UNC13B has several biochemical functions, for example, diacylglycerol binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UNC13B itself. We selected most functions UNC13B had, and list some proteins which have the same functions with UNC13B. You can find most of the proteins on our site.

    Function Related Protein
    diacylglycerol binding TRPC2; RASGRP4; RASGRP3; RASGRP2; RASGRP1; UNC13C; UNC13B; CDIPT; UNC13A
    metal ion binding SCRT1; NRD1B; PM20D1.2; ZNF644A; TERT; HBB-BH1; ALKBH5; ADPRHL2; Car4; BMP1A
    protein binding AGER; EHD3; IL15RA; ELMO2; FAM90A1; MYD88; ADM; DCLRE1C; FBXO9; CHD8
    receptor activity IGF2R; PAQR5; TLR3; PVRL1A; SMAGP; IL10RA; CUBN; ITGAX; CADM2; RNF139
    signal transducer activity OPN4B; TAAR14A; OLFR958; GNA13B; GNA15.4; TAS2R120; CBLC; BCAR1; AVPR2L; OLFCG4

    UNC13B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UNC13B here. Most of them are supplied by our site. Hope this information will be useful for your research of UNC13B.

    hslO; TOE1

    Kabachinski, G; Yamaga, M; et al. CAPS and Munc13 utilize distinct PIP2-linked mechanisms to promote vesicle exocytosis. MOLECULAR BIOLOGY OF THE CELL 25:508-521(2014).
    Lauterbach, EC; et al. Psychotropic drug effects on gene transcriptomics relevant to Parkinson's disease. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 38:107-115(2012).

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