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UNC13B

  • Official Full Name

    unc-13 homolog B (C. elegans)

  • Overview

    This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.
  • Synonyms

    UNC13B; unc-13 homolog B (C. elegans); unc 13 like (C. elegans) , UNC13; protein unc-13 homolog B; hmunc13; Unc13h2; MGC133279; MGC133280; munc13; Munc13-2; UN13B_HUMAN; UNC13; homolog of rat Munc13 (diacylglycerol-binding);

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human UNC13B-3596H Recombinant Human UNC13B, GST-tagged E.coli GST 1-330aa
Mouse UNC13B-17841M Recombinant Mouse UNC13B Protein Mammalian Cell His
Mouse UNC13B-9910M-B Recombinant Mouse UNC13B Protein Pre-coupled Magnetic Beads HEK293
Mouse UNC13B-9910M Recombinant Mouse UNC13B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat UNC13B-6445R Recombinant Rat UNC13B Protein Mammalian Cell His
Rat UNC13B-6101R-B Recombinant Rat UNC13B Protein Pre-coupled Magnetic Beads HEK293
Rat UNC13B-6101R Recombinant Rat UNC13B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • UNC13B Related Articles
  • UNC13B Related Research Area

UNC13B involved in several pathways and played different roles in them. We selected most pathways UNC13B participated on our site, such as Acetylcholine Neurotransmitter Release Cycle, Dopamine Neurotransmitter Release Cycle, Effects of Botulinum toxin, which may be useful for your reference. Also, other proteins which involved in the same pathway with UNC13B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Acetylcholine Neurotransmitter Release CyclePPFIA1;CCDC167;RAB3AB;CHAT;BZRAP1;SYT1A;STXBP1A;UNC13B;RAB3AA
Dopamine Neurotransmitter Release CyclePPFIA1;PPFIA4;LIN7B;SYN1;SYN3;LIN7A;LIN7C;UNC13B;CPLX1
Effects of Botulinum toxinUNC13B;CCDC167;CHRNA1;RAB3GAP2
Glutamate Neurotransmitter Release CycleSLC1A3A;UNC13B;CPLX2L;CPLX1;SLC1A7A;PPFIA2;SNAP25A;BZRAP1;RERG
Monoamine TransportSCAMP2;TPH2;UNC13B;SYN1;DBH;HRH3;FBXO32;TGFB1I1
Neuronal SystemKCNQ2A;KCND2;KCNH1A;KCNJ1A.6;LIN7A;STXBP1A;KCNAB1;KCNK1B;KCNK10B
Neurotransmitter Release CyclePPFIA4;SNAP25A;RAB3AB;RERG;STXBP1A;SLC1A2A;SYN1;LIN7C;BZRAP1
Norepinephrine Neurotransmitter Release CycleUNC13B;PPFIA1;PPFIA4;STXBP1A;CPLX2L;PPFIA2;RAB3AA;CPLX1;SNAP25A

UNC13B has several biochemical functions, for example, diacylglycerol binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UNC13B itself. We selected most functions UNC13B had, and list some proteins which have the same functions with UNC13B. You can find most of the proteins on our site.

Function Related Protein
diacylglycerol bindingUNC13C;RASGRP2;UNC13B;RASGRP3;TRPC2;RASGRP4;RASGRP1;UNC13A;CDIPT
metal ion bindingZNF707;RPE65;ZNF367;SP1;ZDHHC16A;KLF13;RNF148;FAM96A;CAR13
protein bindingGABRG2;CUL2;EMG1;NRBF2;IGFBP7;ARNTL1B;CXorf48;CCT7;IRF9
receptor activityNLGN2;GRIK3;ICAM1;KLRK1;CLEC4E;NOTCH4;RAMP3;PVRL1A;LILRA3
signal transducer activityOLFCH1;PLCL2;VMN1R48;IRS1;MRGPRG;SH2B1;GNAI2A;FPR-RS3;OLFCG2

UNC13B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UNC13B here. Most of them are supplied by our site. Hope this information will be useful for your research of UNC13B.

hslO; TOE1

Kabachinski, G; Yamaga, M; et al. CAPS and Munc13 utilize distinct PIP2-linked mechanisms to promote vesicle exocytosis. MOLECULAR BIOLOGY OF THE CELL 25:508-521(2014).
Lauterbach, EC; et al. Psychotropic drug effects on gene transcriptomics relevant to Parkinson's disease. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 38:107-115(2012).
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