|Official Full Name||unc-13 homolog B (C. elegans)|
|Background||This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.|
|Synonyms||UNC13B; unc-13 homolog B (C. elegans); unc 13 like (C. elegans) , UNC13; protein unc-13 homolog B; hmunc13; Unc13h2; MGC133279; MGC133280; munc13; Munc13-2; UN13B_HUMAN; UNC13; homolog of rat Munc13 (diacylglycerol-binding)|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
UNC13B involved in several pathways and played different roles in them. We selected most pathways UNC13B participated on our site, such as Acetylcholine Neurotransmitter Release Cycle, Dopamine Neurotransmitter Release Cycle, Effects of Botulinum toxin, which may be useful for your reference. Also, other proteins which involved in the same pathway with UNC13B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Acetylcholine Neurotransmitter Release Cycle||BZRAP1; UNC13B; STXBP1A; PPFIA4; CPLX1; CHAT; SNAP25B; PPFIA1; RERG; SLC18A3A|
|Dopamine Neurotransmitter Release Cycle||LIN7A; SYN1; Apba1; PPFIA4; CCDC167; SYN3; PPFIA1; LIN7C; RERG; UNC13B|
|Effects of Botulinum toxin||CHRNA1; CCDC167; UNC13B; RAB3GAP2|
|Glutamate Neurotransmitter Release Cycle||ARL6IP5A; CCDC167; CPLX2L; SYT1A; RAB3AA; UNC13B; BZRAP1; RAB3AB; CPLX1; SLC1A2A|
|Monoamine Transport||HRH3; FBXO32; UNC13B; DBH; SYN1; TGFB1I1; SCAMP2; TPH2|
|Neuronal System||KCNQ2A; SLC6A11; NSFA; LIN7A; KCNH1B; PPFIA4; KCNJ11; KCNA4; CACNG2B; KCNK3A|
|Neurotransmitter Release Cycle||SNAP25A; STXBP1A; PPFIA4; CPLX2L; SLC17A7A; RAB3AB; SNAP25B; SLC1A7A; LIN7B; SYT1A|
|Norepinephrine Neurotransmitter Release Cycle||SNAP25B; PPFIA2; RAB3AA; PPFIA1; SNAP25A; CPLX1; PPFIA4; STXBP1A; SYT1A; UNC13B|
UNC13B has several biochemical functions, for example, diacylglycerol binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UNC13B itself. We selected most functions UNC13B had, and list some proteins which have the same functions with UNC13B. You can find most of the proteins on our site.
|diacylglycerol binding||TRPC2; RASGRP4; RASGRP3; RASGRP2; RASGRP1; UNC13C; UNC13B; CDIPT; UNC13A|
|metal ion binding||SCRT1; NRD1B; PM20D1.2; ZNF644A; TERT; HBB-BH1; ALKBH5; ADPRHL2; Car4; BMP1A|
|protein binding||AGER; EHD3; IL15RA; ELMO2; FAM90A1; MYD88; ADM; DCLRE1C; FBXO9; CHD8|
|receptor activity||IGF2R; PAQR5; TLR3; PVRL1A; SMAGP; IL10RA; CUBN; ITGAX; CADM2; RNF139|
|signal transducer activity||OPN4B; TAAR14A; OLFR958; GNA13B; GNA15.4; TAS2R120; CBLC; BCAR1; AVPR2L; OLFCG4|
UNC13B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UNC13B here. Most of them are supplied by our site. Hope this information will be useful for your research of UNC13B.