UNC13B
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Official Full Name
unc-13 homolog B (C. elegans) -
Overview
This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. -
Synonyms
UNC13B;unc-13 homolog B (C. elegans);unc 13 like (C. elegans) , UNC13;protein unc-13 homolog B;hmunc13;Unc13h2;MGC133279;MGC133280;munc13;Munc13-2;UN13B_HUMAN;UNC13;homolog of rat Munc13 (diacylglycerol-binding)
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| UNC13B-3596H | Recombinant Human UNC13B, GST-tagged | E.coli | Human | GST | 1-330aa | |
| UNC13B-17841M | Recombinant Mouse UNC13B Protein | Mammalian Cells | Mouse | His |
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| UNC13B-6445R | Recombinant Rat UNC13B Protein | Mammalian Cells | Rat | His |
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| UNC13B-6101R | Recombinant Rat UNC13B Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| UNC13B-6101R-B | Recombinant Rat UNC13B Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| UNC13B-9910M | Recombinant Mouse UNC13B Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| UNC13B-9910M-B | Recombinant Mouse UNC13B Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
UNC13B involved in several pathways and played different roles in them. We selected most pathways UNC13B participated on our site, such as Acetylcholine Neurotransmitter Release Cycle,Dopamine Neurotransmitter Release Cycle,Effects of Botulinum toxin, which may be useful for your reference. Also, other proteins which involved in the same pathway with UNC13B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Norepinephrine Neurotransmitter Release Cycle | PPFIA4,SNAP25B,SYT1A,CPLX2L,PPFIA2,PPFIA1,BZRAP1,STXBP1A,RERG,RAB3AA |
| Effects of Botulinum toxin | RAB3GAP2,CCDC167,CHRNA1 |
| Acetylcholine Neurotransmitter Release Cycle | CPLX2L,SLC18A3A,STXBP1A,CHAT,PPFIA4,SNAP25A,PPFIA1,RERG,PPFIA2,SYT1A |
| Neuronal System | KCNG3,KCNK7,KCNJ1A.6,KCNA2,KCNA6,KCNK16,KCNK2B,SLC1A2A,KCNK1A,LIN7C |
| Glutamate Neurotransmitter Release Cycle | ARL6IP5B,CPLX2L,SLC1A2A,SLC1A7A,RAB3AB,BZRAP1,PPFIA4,ARL6IP5A,RERG,SLC1A3A |
| Monoamine Transport | DBH,TGFB1I1,FBXO32,SYN1,HRH3,SCAMP2,TPH2 |
| Neurotransmitter Release Cycle | SYN2,CPLX1,PPFIA1,RERG,RAB3AB,SLC18A3A,SLC1A2A,LIN7A,SLC1A2B,GLS2B |
| Dopamine Neurotransmitter Release Cycle | Apba1,SYN2,PPFIA4,LIN7C,CCDC167,CPLX1,LIN7A,PPFIA2,PPFIA1,SYN3 |
Protein Function
UNC13B has several biochemical functions, for example, diacylglycerol binding,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UNC13B itself. We selected most functions UNC13B had, and list some proteins which have the same functions with UNC13B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| diacylglycerol binding | RASGRP3,RASGRP1,UNC13C,CDIPT,TRPC2,RASGRP4,RASGRP2,UNC13A |
| protein binding | IL24,TEKT3,PLUNC,KAT2B,CAP2,USHBP1,ATP2A2,CTNNB1,UBE4A,ZCCHC17 |
| metal ion binding | ZNF335,GM3258,ARID2,TRIM8A,MOBKL1A,XPA,ZNF544,ACO1,CA15C,LIMS2 |
| receptor activity | RNF139,F2RL1,ATP6AP2,CD33,TNFRSF17,NOTCH1A,GRIN1A,CD160,KIR2DL1,GRIK3 |
| signal transducer activity | PLCB2,SH2B1,GNB5,TAS2R200.2,GNB1,GNAV1,RGRA,TAS2R103,OLFR478,LPAR2B |
Interacting Protein
UNC13B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UNC13B here. Most of them are supplied by our site. Hope this information will be useful for your research of UNC13B.
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References
- Kabachinski, G; Yamaga, M; et al. CAPS and Munc13 utilize distinct PIP2-linked mechanisms to promote vesicle exocytosis. MOLECULAR BIOLOGY OF THE CELL 25:508-521(2014).
- Lauterbach, EC; et al. Psychotropic drug effects on gene transcriptomics relevant to Parkinson's disease. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 38:107-115(2012).
