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VAV2

  • Official Full Name

    vav 2 guanine nucleotide exchange factor

  • Overview

    Vav proteins belong to the Dbl family of guanine nucleotide exchange factors (GEFs) for Rho/Rac small GTPases. The three identified mammalian Vav proteins (Vav1, Vav2 and Vav3) differ in their expression. Vav1 is expressed only in hematopoietic cells and
  • Synonyms

    VAV2; vav 2 guanine nucleotide exchange factor; vav 2 oncogene; guanine nucleotide exchange factor VAV2; VAV-2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human VAV2-3653H Recombinant Human VAV2, GST-tagged E.coli GST 98-326aa
Human VAV2-422HCL Recombinant Human VAV2 293 Cell Lysate HEK293 N/A
Human VAV2-496H Recombinant Human VAV2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human VAV2-549H Recombinant Human VAV2 Protein, His-tagged E.coli N-His Met1-Ser119
Mouse VAV2-17990M Recombinant Mouse VAV2 Protein Mammalian Cell His
Mouse Vav2-6905M Recombinant Mouse Vav2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse VAV2-10001M Recombinant Mouse VAV2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse VAV2-10001M-B Recombinant Mouse VAV2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque VAV2-5148R Recombinant Rhesus monkey VAV2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque VAV2-4961R-B Recombinant Rhesus Macaque VAV2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque VAV2-4961R Recombinant Rhesus Macaque VAV2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken VAV2-5718C Recombinant Chicken VAV2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • VAV2 Related Articles
  • VAV2 Related Signal Pathway

VAV2 involved in several pathways and played different roles in them. We selected most pathways VAV2 participated on our site, such as Rap signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with VAV2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Rap signaling pathwayITGB2L;ITGB1;ITGAM;PRKD3;RRAS;ANGPT2;PRKCZ;NGF;PIK3R1
cAMP signaling pathwayFOS;DRD1A;PTCH1;MAPK8;GNAI1;GRIA4;NFATC1;SUCNR1;PPP1CB
Chemokine signaling pathwayGNAI3;GNGT1;PRKACB;CCL27;GRK1;Ccl21a;CCR7;NFKB1;GRB2
Focal adhesionITGA3;PRKCG;CAV2;ITGB5;IGF1RB;PIK3R3B;MYL9;VWF;ITGA7
Natural killer cell mediated cytotoxicityPPP3R1;PTPN6;IFNGR2;KIR3DL2;PPP3R2;PIK3CB;ARAF;HLA-B;GM-CSF
T cell receptor signaling pathwayMAP3K7;PPP3CB;PDPK1;MAPK1;LCP2;NRAS;AKT2;MAPK3;NCK1
B cell receptor signaling pathwayRAC2;INPPL1;NFKBIA;SLA2;CDK2;PIK3CB;NFKBIE;PIK3R2;CD79A
Fc epsilon RI signaling pathwayGM-CSF;MAPK13;PIK3R1;MAPK8;RAF1;MAPK10;IL13;FCER1A;FCER1G
Fc gamma R-mediated phagocytosisPRKCG;PIK3CG;ASAP3;PTPRC;VASP;INPP5D;NCF1;FCGR2A;PLA2G4D
Leukocyte transendothelial migrationCLDN11;MSN;MMP2;RHOA;MYL2;ACTN4;MYL7;BCAR1;CLDN4
Regulation of actin cytoskeletonARPC5LA;PAK7;SSH1;EGFRA;ARPC5LB;FGF6A;ACTN3B;CFL2L;INS
Proteoglycans in cancerARHGEF1;TGFB2;TFAP4;WNT1;PPP1CA;WNT7A;ITGB5;PRKCB;PIK3CB

VAV2 has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity, epidermal growth factor receptor binding, guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by VAV2 itself. We selected most functions VAV2 had, and list some proteins which have the same functions with VAV2. You can find most of the proteins on our site.

Function Related Protein
Rho guanyl-nucleotide exchange factor activityC3A.1;ECT2;KALRNB;ARHGEF9;ARHGEF7;FGD1;ARHGEF1A;ARHGEF1;ALS2CL
epidermal growth factor receptor bindingGRB2;MS4A1;SOCS5;HBEGF;RNF126;HBEGFB;BTC;HBEGFA;VAV3
guanyl-nucleotide exchange factor activityTBXAS1;RIC8;DENND5B;DENND4B;VAV3B;TBXA2R;ANKRD27;FGD3;DOCK1
metal ion bindingSMAP1;GALNT18A;PLA2G3;TRIM59;ZFP322A;CA4A;VDRB;ZFP13;MICAL2
protein bindingPTPN3;RAB26;KRT16;ATG12;FPR1;PRKAA1;CCNDBP1;TAS2R16;PVR

VAV2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VAV2 here. Most of them are supplied by our site. Hope this information will be useful for your research of VAV2.

SH3BP2; TTN; TOM1L1; ERBB2; MET; AR; ERBB3; GAB1; ABI1; Mbp; PRLR

Birukova, AA; Tian, YF; et al. VE-cadherin trans-interactions modulate Rac activation and enhancement of lung endothelial barrier by iloprost. JOURNAL OF CELLULAR PHYSIOLOGY 227:3405-3416(2012).
Molli, PR; Adam, L; et al. Therapeutic IMC-C225 Antibody Inhibits Breast Cancer Cell Invasiveness via Vav2-Dependent Activation of RhoA GTPase. CLINICAL CANCER RESEARCH 14:6161-6170(2008).
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