VAV2 Protein, vav 2 guanine nucleotide exchange factor


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Official Full Name vav 2 guanine nucleotide exchange factor
Background Vav proteins belong to the Dbl family of guanine nucleotide exchange factors (GEFs) for Rho/Rac small GTPases. The three identified mammalian Vav proteins (Vav1, Vav2 and Vav3) differ in their expression. Vav1 is expressed only in hematopoietic cells and
Synonyms VAV2; vav 2 guanine nucleotide exchange factor; vav 2 oncogene; guanine nucleotide exchange factor VAV2; VAV-2
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human VAV2-3653H Recombinant Human VAV2, GST-tagged E.coli GST
    Human VAV2-422HCL Recombinant Human VAV2 293 Cell Lysate HEK293 N/A
    Mouse VAV2-17990M Recombinant Mouse VAV2 Protein Mammalian Cell His
    Rhesus Macaque VAV2-5148R Recombinant Rhesus monkey VAV2 Protein, His-tagged Mammalian Cell His
    Chicken VAV2-5718C Recombinant Chicken VAV2 Mammalian Cell His

    VAV2 involved in several pathways and played different roles in them. We selected most pathways VAV2 participated on our site, such as Rap signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with VAV2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Rap signaling pathway FYB; PRKD3; GNAO1; FGF6; CALM4; MAP2K6; PLCB4; PIK3CD; CDH1; AKT2
    cAMP signaling pathway HTR1B; RYR2; GABBR1; MC2R; LIPE; PIK3CB; GNAS; GRIN2D; GHSR; HCAR3
    Chemokine signaling pathway AMCF-II; Ccl27a; PIK3CB; IKBKG; CCL7; CXCL16; GNG2; CXCL5; CCR5; RAP1B
    Focal adhesion PDPK1; VAV2; FLNC; VASP; ITGA2B; COMP; ITGA9; COL27A1B; MYLK3; COL11A2
    Natural killer cell mediated cytotoxicity RAET1E; CD244; RAET1D; Casp3; KLRK1; Raet1a; MICA; Raet1c; HCST; Ifna11
    T cell receptor signaling pathway PAK2; MAPK9; MAP3K14; MAPK12; LCK; GRAP2; LAT; TEC; IKBKB; MAP3K7
    B cell receptor signaling pathway INPP5D; PPP3CB; NFATC1; PTPN18; Cd79a, Cd79b; PPP3CA; PTPN6; PPP3R1; FOS; GSK3B
    Fc epsilon RI signaling pathway PIK3CA; MAP2K4; PIK3R2; PIK3R3; NRAS; PLA2G4D; RAC2; KRAS; VAV1; FCER1G
    Fc gamma R-mediated phagocytosis CDC42; SPHK2; CFL2; MARCKSL1; MAP2K1; PIP5K1A; DOCK2; WAS; VAV3; PLA2G4F
    Leukocyte transendothelial migration CXCR4; CLDN11; NOX1; F11R; ITGB1; CLDN16; ACTN1; PXN; ACTN2; MYL10
    Regulation of actin cytoskeleton RHOAA; SSH3; CHRM5B; ACTB2; GNG12; ARHGEF6; ITGB3B; ACTN3; LIMK1; FGF10
    Proteoglycans in cancer NRAS; ESR1; IGF1R; FAS; CBLC; TWIST1; COL21A1; PPP1CA; SRC; RPS6KB2

    VAV2 has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity, epidermal growth factor receptor binding, guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by VAV2 itself. We selected most functions VAV2 had, and list some proteins which have the same functions with VAV2. You can find most of the proteins on our site.

    Function Related Protein
    Rho guanyl-nucleotide exchange factor activity ARHGEF28; VAV3B; BCR; AKAP13; ARHGEF6; DCLRE1B; ARHGEF12; ABR; VAV2; FGD2
    epidermal growth factor receptor binding EGF; PLSCR1; SNX2; RNF126; CBLC; VAV2; AREG; VAV3; AGR2; Fert2
    guanyl-nucleotide exchange factor activity RASGRF2B; ARHGEF39; GAPVD1; ARHGEF7; FLCN; RAPGEFL1; SBF1; DOCK1; DOCK4; RALGDS
    metal ion binding HCCS; BCL6AB; CDH15; MARCH6; TREX1; GTPBP6; DSG1C; EGR2A; GDPD1; KLF11B
    protein binding CYTH3; SPATA2; NAA16; POC1B; ARVCF; ZNF670; MATN1; ABHD1; AMFR; LBP

    VAV2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VAV2 here. Most of them are supplied by our site. Hope this information will be useful for your research of VAV2.


    Birukova, AA; Tian, YF; et al. VE-cadherin trans-interactions modulate Rac activation and enhancement of lung endothelial barrier by iloprost. JOURNAL OF CELLULAR PHYSIOLOGY 227:3405-3416(2012).
    Molli, PR; Adam, L; et al. Therapeutic IMC-C225 Antibody Inhibits Breast Cancer Cell Invasiveness via Vav2-Dependent Activation of RhoA GTPase. CLINICAL CANCER RESEARCH 14:6161-6170(2008).

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