wwp1
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  • Official Full Name
  • WW domain containing E3 ubiquitin protein ligase 1
  • Background
  • WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008]
  • Synonyms
  • WWP1; WW domain containing E3 ubiquitin protein ligase 1; AIP5; Tiul1; hSDRP1; NEDD4-like E3 ubiquitin-protein ligase WWP1; WW domain-containing protein 1; atrophin-1 interacting protein 5; atrophin-1-interacting protein 5; TGIF-interacting ubiquitin ligase 1; Nedd-4-like ubiquitin-protein ligase;
Cat.#:WWP1-31531THTag:Flag
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human WWP1, FLAG-tagged
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Cat.#:WWP1-477HTag:Flag
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human WWP1, GST-tagged
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Cat.#:WWP1-75HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human WWP1, GST-tagged
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Cat.#:WWP1-5224RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey WWP1 Protein, His-tagged
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Cat.#:WWP1-1926CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken WWP1
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Cat.#:WWP1-273HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human WWP1 293 Cell Lysate
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Involved Pathway

WWP1 involved in several pathways and played different roles in them. We selected most pathways WWP1 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with WWP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
DYNLL2; RBCK1; FRS2A; FBXO27; CD160; ARIH2; KLRB1B; MGC174152; HBEGF; GRAP2B
Antigen processing: Ubiquitination &
FBXO44; UBE2L6; RNF41; ASB8; UBE2J2; LRRC41; UBE2V1; UBE2E3; WSB1; TPP2
Proteasome degradation
UBR1; RNF14; FBXO27; UBE2U; ASB14; TRIM11; UFL1; RNF6; RNF4; RNF34
Class I MHC mediated antigen processing &
RNF220; TRAF7; UBE2U; ASB9; UBE2J2; UBA5; LRSAM1; TRIM69; UBE2L6; LRRC41
presentation
ATG7; UBE2E3; LRR1; TRIM69; TRIM11; ASB17; SPSB4; SEC24A; ASB13; LRSAM1
Downregulation of ERBB4 signaling
WWP1
Endocytosis
PSD2; CHMP4C; ERBB4; EHD1B; GIT2A; EPN2; DNAJC6; ARF6B; RAB11FIP4; PIP5K1B
ErbB4 signaling events
YAP1; WWP1; CBFA2T3; WWOX
Immune System
CD200R2; RCA2.1; RNF138; DEFA3; PELI1; IFI6; KIF4A; SIGLEC9; XAF1; LTF
Ion channel transport
TRPC4APB; BEST1; GABRR2A; ATP13A5; TCIRG1; TPCN1; CLCN4; ANO5; TRPM4A; CLIC2

Protein Function

WWP1 has several biochemical functions, for example, ligase activity, protein binding, ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by WWP1 itself. We selected most functions WWP1 had, and list some proteins which have the same functions with WWP1. You can find most of the proteins on our site.
Function
Related Protein
Function ligase activity
Related Protein RFWD2; RTCD1; RNF135; DTX4; RNF152; TRIM2; CNOT4; SIAH1A; HLTF; PIAS4
Function protein binding
Related Protein JAG1; ZFP36L1; LIG4; SDHAF2; GIMAP7; INTS5; SUMO3; TYRO3; TBC1D20; CNOT7
Function ubiquitin protein ligase activity
Related Protein TRIM63; NHLRC1; HLTF; UBR3; RNF222; FBXL22; FANCF; PRPF19; UBE2W; MDM2
Function ubiquitin-protein transferase activity
Related Protein UBE2R2; MGRN1; UBE3A; FBXL21; TRIM68; TRIM71; UBR3; MARCH2; ZNF738; PDZRN3B

Interacting Protein

WWP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WWP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of WWP1.
CPSF6; SMAD3; q8wu02_human; FBXL18; TRAF4; HSP90AB1; FBXL15; PHF20L1; WASL