wwp1
Share
  • Official Full Name
  • WW domain containing E3 ubiquitin protein ligase 1
  • Background
  • WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008]
  • Synonyms
  • WWP1; WW domain containing E3 ubiquitin protein ligase 1; AIP5; Tiul1; hSDRP1; NEDD4-like E3 ubiquitin-protein ligase WWP1; WW domain-containing protein 1; atrophin-1 interacting protein 5; atrophin-1-interacting protein 5; TGIF-interacting ubiquitin ligase 1; Nedd-4-like ubiquitin-protein ligase;
Cat.#:WWP1-31531THTag:Flag
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human WWP1, FLAG-tagged
+Inquiry
Cat.#:WWP1-477HTag:Flag
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human WWP1, GST-tagged
+Inquiry
Cat.#:WWP1-75HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human WWP1, GST-tagged
+Inquiry
Cat.#:WWP1-5224RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey WWP1 Protein, His-tagged
+Inquiry
Cat.#:WWP1-1926CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken WWP1
+Inquiry
Cat.#:WWP1-273HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human WWP1 293 Cell Lysate
+Inquiry

Involved Pathway

WWP1 involved in several pathways and played different roles in them. We selected most pathways WWP1 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with WWP1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
HLA-DQB2; VPRBP; MAP3K8; KLRB1A; GM11711; KLB; CTSC; SPSB2; KIF2A; DYNC1I1
Antigen processing: Ubiquitination &
TRIM11; SPSB1; CMTM2A; RNF144B; RNF220; MKRN1; ASB11; FBXO27; GAN; UBE2V1
Proteasome degradation
BLMH; TRIM39; RNF19B; RNF4; FBXO3; RNF111; UBR2; IWS1; UBR1; ARIH2
Class I MHC mediated antigen processing &
SEC61B; RNF14; ERAP2; HUWE1; FBXO3; PJA1; ASB4; ASB18; ATG7; TPP2
presentation
SH3RF1; SEC23A; MKRN1; SPSB4; ARIH2; ASB9; RNF138; LTN1; CMTM2A; VPRBP
Downregulation of ERBB4 signaling
WWP1
Endocytosis
PARD6A; RHOA; CXCR4A; CBL; RAB11FIP3; IL2RG; DNM1B; RAB4A; ARPC1A; SMURF2
ErbB4 signaling events
WWP1; YAP1; WWOX; CBFA2T3
Immune System
TRIM68; ERAP1; GBP2; AGER; FBXO17; NLRP4C; CFHL2; BTR29; IRF9; FCN3
Ion channel transport
FKBP1B; GSDMA2; TRPM4C; TRPC4AP; CLCNK; TRPV3; ATP8B1; TRPM1A; CLCN7; SRI

Protein Function

WWP1 has several biochemical functions, for example, ligase activity, protein binding, ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by WWP1 itself. We selected most functions WWP1 had, and list some proteins which have the same functions with WWP1. You can find most of the proteins on our site.
Function
Related Protein
Function ligase activity
Related Protein RNF130; TRIM68; HECTD3; UBE2KB; TRIM31; HECW2; TRIM62; TRIM4; PCXB; HECW1B
Function protein binding
Related Protein LRCH1; BCL11B; KTN1; SIAH2; ZNF524; P2RY6; KPNA2; MRPL9; GABARAPL1; NCKAP1
Function ubiquitin protein ligase activity
Related Protein UBE3B; UBE2G1B; RNF25; MDM2; HUWE1; UHRF2; TMEM189; RNF41; PDZRN3; RNF19B
Function ubiquitin-protein transferase activity
Related Protein UBE2M; MALT1; FBXO4; ZNF738; TRAF4A; TRIM68; LMO7; FBXO40.1; FBXL5; MYLIP

Interacting Protein

WWP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WWP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of WWP1.
CPSF6; SMAD3; q8wu02_human; FBXL18; TRAF4; HSP90AB1; FBXL15; PHF20L1; WASL