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  • Official Full Name

    abhydrolase domain containing 2

  • Overview

    This gene encodes a protein containing an alpha/beta hydrolase fold, which is a catalytic domain found in a very wide range of enzymes. The function of this protein has not been determined. Alternative splicing of this gene results in two transcript variants encoding the same protein.
  • Synonyms

    ABHD2; abhydrolase domain containing 2; abhydrolase domain-containing protein 2; LABH2; protein PHPS1-2; lung alpha/beta hydrolase 2; alpha/beta hydrolase domain containing protein 2; HS1-2; PHPS1-2; MGC26249; MGC111112;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Homo sapiens (Human)
  • Human
  • Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
  • Mouse
  • Mus musculus (Mouse)
  • Rhesus Macaque
  • E.coli
  • E.coli expression system
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • C
  • Myc
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc|DDK
  • N/A
  • N
  • His6ABP
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ABHD2-9240H Recombinant Human ABHD2, GST-tagged E.coli GST C-term-301a.a.
Human ABHD2-3040H Recombinant Human ABHD2, His-tagged E.Coli or Yeast His 425
Human ABHD2-4893H Recombinant Human ABHD2 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ABHD2-9134HCL Recombinant Human ABHD2 293 Cell Lysate HEK293 N/A
Human ABHD2-9135HCL Recombinant Human ABHD2 293 Cell Lysate HEK293 N/A
Human ABHD2-494H Recombinant Human ABHD2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ABHD2-248H-B Recombinant Human ABHD2 Protein Pre-coupled Magnetic Beads HEK293
Human ABHD2-03H Recombinant Human ABHD2 Protein, N-His6ABP-tagged E.coli N-His6ABP
Human ABHD2-867HFL Recombinant Full Length Human ABHD2 Protein, C-Flag-tagged Mammalian cells Flag
Human ABHD2-248H Recombinant Human ABHD2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ABHD2-02H Recombinant Human ABHD2 Protein, C-Myc/DDK-tagged HEK293T C-Myc/DDK
Human ABHD2-301H Recombinant Human ABHD2 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Mouse ABHD2-1131M Recombinant Mouse ABHD2 Protein Mammalian Cell His
Mouse ABHD2-215M-B Recombinant Mouse ABHD2 Protein Pre-coupled Magnetic Beads HEK293
Mouse ABHD2-215M Recombinant Mouse ABHD2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Abhd2-1471M Recombinant Mouse Abhd2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Bos taurus (Bovine) RFL1000BF Recombinant Full Length Bovine Abhydrolase Domain-Containing Protein 2(Abhd2) Protein, His-Tagged E.coli expression system His Full Length (1-425)
Homo sapiens (Human) RFL-5150HF Recombinant Full Length Human Monoacylglycerol Lipase Abhd2(Abhd2) Protein, His-Tagged E.coli expression system His Full Length (1-425)
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) RFL2237MF Recombinant Full Length Macaca Fascicularis Abhydrolase Domain-Containing Protein 2(Abhd2) Protein, His-Tagged E.coli expression system His Full Length (1-425)
Mus musculus (Mouse) RFL3398MF Recombinant Full Length Mouse Abhydrolase Domain-Containing Protein 2(Abhd2) Protein, His-Tagged E.coli expression system His Full Length (1-425)
Rhesus Macaque ABHD2-190R Recombinant Rhesus monkey ABHD2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ABHD2-19R-B Recombinant Rhesus Macaque ABHD2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ABHD2-19R Recombinant Rhesus Macaque ABHD2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ABHD2 Related Articles

ABHD2 involved in several pathways and played different roles in them. We selected most pathways ABHD2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ABHD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

ABHD2 has several biochemical functions, for example, carboxylic ester hydrolase activity, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by ABHD2 itself. We selected most functions ABHD2 had, and list some proteins which have the same functions with ABHD2. You can find most of the proteins on our site.

Function Related Protein
carboxylic ester hydrolase activityACOT10;Ces2c;ACOT8;ACOT2;CES2;FAM135B;Ces2e;AADACL4;CES3A

ABHD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABHD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABHD2.

Stelmanska, E; Szrok, S; et al. Progesterone-induced down-regulation of hormone sensitive lipase (Lipe) and up-regulation of G0/G1 switch 2 (G0s2) genes expression in inguinal adipose tissue of female rats is reflected by diminished rate of lipolysis. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 147:31-39(2015).
Wiedl, T; Arni, S; et al. Activity-based proteomics: Identification of ABHD11 and ESD activities as potential biomarkers for human lung adenocarcinoma. JOURNAL OF PROTEOMICS 74:1884-1894(2011).
  • Q&As
  • Reviews

Q&As (10)

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Where does the ABHD2 express in mouse? Any function in mouse? 01/10/2022

Tthe mouse ABHD2 is expressed in vascular smooth muscle cells (SMCs) and that enhanced migration occurs with cultured vascular SMCs from Abhd2-deficient mice. Enhanced neointimal hyperplasia was observed in ABHD2-deficient mice.

Where does the ABHD2 express strongly? 10/05/2021

This protein is strongly expressed in human spermatozoa. It is a key controller of sperm hyperactivation, which is a necessary step in allowing sperm to fertilize an egg.

Is there any bioloical application of ABHD2 membrane protein? 08/31/2021

Yes. Endogenous steroids and plant triterpenoids can influence CatSper activation via modulation of ABHD2.

What kind of biological techique can be used to identify inhibitors for ABHD2? 11/29/2020

A gel-based assay using MB064 was employed to identify novel inhibitors for ABHD2.

What is the biological function of the ABHD2 protein in the presence of progesterone (or Pregnenolone Sulfate)? 10/30/2019

In the presence of Progesterone (or Pregnenolone Sulfate) it cleaves 2-arachidonoylglycerol (2AG) into glycerol and arachidonic acid (AA). 2AG inhibits sperm calcium channel CatSper, and so when ABHD2 removes 2AG calcium flows into the cell through the CatSper channel, leading to hyperactivation. ABHD2 is inhibited by testosterone, (as well as hydrocortisone, and the plant triterpenoids lupeol and pristimerin) which may prevent premature hyperactivation.

How does the ABHD2 gene influence the ovaria? 07/28/2019

Suppression of ABHD2 may promote a malignant phenotype and poor prognosis for women with serous ovarian cancer.

How to prove the ABHD2 play a important role in accelerating proliferation of cancer cells? 07/12/2019

The human ABHD2 protein sequence shows an α/β hydrolase domain with conserved GXSXG lipase motif. To study the role of this conserved GXSXG domain, ABHD2 was cloned, overexpressed and the recombinant protein was used for in vitro enzyme assays. The results obtained with His-tag purified recombinant ABHD2 protein clearly displayed both TAG lipase and ester hydrolase activities.

What is the role of ABHD2 in human disease? 08/19/2018

The ABHD2 gene is down regulated in the lungs of people with Emphysema. ABHD2 is important in maintaining the structural integrity of the lungs, and that disruption of phospholipid metabolism in the alveoli may lead to the development of emphysema. Increased expression has also been seen in the lungs of smokers.

Is there any association of ABHD2 expression and clinicopathological factors in the high-grade serous ovarian cancer? 05/30/2018

The prognosis of the low-ABHD2 group patients was significantly worse as compared to that of the high group patients

Are these any other co-gene affect the resistance of anoikis, simiar as the ABHD2? 05/11/2018

By performing a functional genomics screen using an shRNA library to search for drivers of anoikis resistance in high-grade serous ovarian cancer, we can successfully identified three genes, ABHD2, ELAC2 and CYB5R3 whose downregulation increased resistance to anoikis.

Customer Reviews (5)

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    I have never in my life received products so quickly following my order!


      Great performance in ELISA.


        Good product.It is a first choice.


          This antibody works very well for our samples.


            This product provide detailed instructions, including application, storage condition, etc. Love it!

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