ABHD2
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Official Full Name
abhydrolase domain containing 2
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Overview
This gene encodes a protein containing an alpha/beta hydrolase fold, which is a catalytic domain found in a very wide range of enzymes. The function of this protein has not been determined. Alternative splicing of this gene results in two transcript variants encoding the same protein. -
Synonyms
ABHD2; abhydrolase domain containing 2; abhydrolase domain-containing protein 2; LABH2; protein PHPS1-2; lung alpha/beta hydrolase 2; alpha/beta hydrolase domain containing protein 2; HS1-2; PHPS1-2; MGC26249; MGC111112;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Homo sapiens (Human)
- Human
- Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
- Mouse
- Mus musculus (Mouse)
- Rhesus Macaque
- E.coli
- E.coli expression system
- E.Coli or Yeast
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- C
- Myc
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc|DDK
- N/A
- N
- His6ABP
- Involved Pathway
- Protein Function
- Interacting Protein
- ABHD2 Related Articles
ABHD2 involved in several pathways and played different roles in them. We selected most pathways ABHD2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ABHD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
ABHD2 has several biochemical functions, for example, carboxylic ester hydrolase activity, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by ABHD2 itself. We selected most functions ABHD2 had, and list some proteins which have the same functions with ABHD2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| carboxylic ester hydrolase activity | ACOT10;Ces2c;ACOT8;ACOT2;CES2;FAM135B;Ces2e;AADACL4;CES3A |
| molecular_function | FAM115E;CSRNP1B;XKR7;MRGPRA5;TANC1;TMEM106C;ENO4;GPR108;SHQ1 |
ABHD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABHD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABHD2.
- Q&As
- Reviews
Q&As (10)
Ask a questionTthe mouse ABHD2 is expressed in vascular smooth muscle cells (SMCs) and that enhanced migration occurs with cultured vascular SMCs from Abhd2-deficient mice. Enhanced neointimal hyperplasia was observed in ABHD2-deficient mice.
This protein is strongly expressed in human spermatozoa. It is a key controller of sperm hyperactivation, which is a necessary step in allowing sperm to fertilize an egg.
Yes. Endogenous steroids and plant triterpenoids can influence CatSper activation via modulation of ABHD2.
A gel-based assay using MB064 was employed to identify novel inhibitors for ABHD2.
In the presence of Progesterone (or Pregnenolone Sulfate) it cleaves 2-arachidonoylglycerol (2AG) into glycerol and arachidonic acid (AA). 2AG inhibits sperm calcium channel CatSper, and so when ABHD2 removes 2AG calcium flows into the cell through the CatSper channel, leading to hyperactivation. ABHD2 is inhibited by testosterone, (as well as hydrocortisone, and the plant triterpenoids lupeol and pristimerin) which may prevent premature hyperactivation.
Suppression of ABHD2 may promote a malignant phenotype and poor prognosis for women with serous ovarian cancer.
The human ABHD2 protein sequence shows an α/β hydrolase domain with conserved GXSXG lipase motif. To study the role of this conserved GXSXG domain, ABHD2 was cloned, overexpressed and the recombinant protein was used for in vitro enzyme assays. The results obtained with His-tag purified recombinant ABHD2 protein clearly displayed both TAG lipase and ester hydrolase activities.
The ABHD2 gene is down regulated in the lungs of people with Emphysema. ABHD2 is important in maintaining the structural integrity of the lungs, and that disruption of phospholipid metabolism in the alveoli may lead to the development of emphysema. Increased expression has also been seen in the lungs of smokers.
The prognosis of the low-ABHD2 group patients was significantly worse as compared to that of the high group patients
By performing a functional genomics screen using an shRNA library to search for drivers of anoikis resistance in high-grade serous ovarian cancer, we can successfully identified three genes, ABHD2, ELAC2 and CYB5R3 whose downregulation increased resistance to anoikis.
Customer Reviews (5)
Write a reviewI have never in my life received products so quickly following my order!
Great performance in ELISA.
Good product.It is a first choice.
This antibody works very well for our samples.
This product provide detailed instructions, including application, storage condition, etc. Love it!
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