ACOX1
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Official Full Name
acyl-CoA oxidase 1, palmitoyl -
Overview
The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified. -
Synonyms
ACOX1;acyl-CoA oxidase 1, palmitoyl;acyl Coenzyme A oxidase 1, palmitoyl;peroxisomal acyl-coenzyme A oxidase 1;PALMCOX;ACOX1_HUMAN;AOX;EC 1.3.3.6;Palmitoyl CoA oxidase;Palmitoyl-CoA oxidase;Peroxisomal acyl coenzyme A oxidase 1;SCOX;Straight chain acyl CoA oxidase;Straight-chain acyl-CoA oxidase;acyl-CoA oxidase, straight-chain;peroxisomal fatty acyl-CoA oxidase;acyl-Coenzyme A oxidase 1, palmitoyl;ACOX
Recombinant Proteins
- Mouse
- Chicken
- Zebrafish
- Human
- Rhesus macaque
- Rat
- Mammalian Cells
- Wheat Germ
- Insect Cells
- E.coli
- In Vitro Cell Free System
- HEK293
- His
- GST
- Non
- Avi
- Fc
- Myc
Involved Pathway
ACOX1 involved in several pathways and played different roles in them. We selected most pathways ACOX1 participated on our site, such as Fatty acid degradation,alpha-Linolenic acid metabolism,Biosynthesis of unsaturated fatty acids, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACOX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PPAR signaling pathway | CYP8B1,GK2,RXRBA,ADIPOQ,RXRGA,PCK2,CYP4A10,SLC27A1B,PCK1,CD36 |
| Fatty acid degradation | ACADM,ACSL1A,CPT1C,ACSL4,CYP4A10,GCDHB,CYP4A14,ALDH3A2,ACSL4A,ALDH9A1B |
| Fatty acid metabolism | CPT1A,ACSL1,ACAT1,Scd1,MCAT,Scd2,TECR,ACSL3B,SCDB,ELOVL2 |
| cAMP signaling pathway | MC2R,OXTR,CAMK2G,GRIA1,GABBR1,NFKBIA,GRIA2,HCAR2,GNAI2,TNNI3 |
| alpha-Linolenic acid metabolism | PLA2G5,FADS2,ACAA1,PLA2G4C,ACOX3,PLA2G2A,PLA2G2F,PLA2G4F,PLA2G4AA,PLA2G12A |
| Peroxisome | PEX5,AGXTB,PECI,DAO.2,XDH,IDH2,ECI2,DDO,ABCD4,PEX19 |
| Biosynthesis of unsaturated fatty acids | ACAA1,HADHAB,Scd1,PECR,FADS2,ELOVL5,BAAT,SCD5,PTPLAD1,ACOT2 |
| Metabolic pathways | PLCD4,NT5C1AA,POLR2J2,AGPAT3,AK8,SDHC,ATP6V1E2,CDA,UGT1A7,CYP2B19 |
Protein Function
ACOX1 has several biochemical functions, for example, FAD binding,PDZ domain binding,acyl-CoA dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACOX1 itself. We selected most functions ACOX1 had, and list some proteins which have the same functions with ACOX1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein N-terminus binding | RPS21,MYO7A,NCOA3,PEX14,SYNGR3,SNCA,RELA,EXOC5,GTF2H2,TRP53 |
| oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor | ACAD8,ACAD9,ACOX2,ACADL,ACADVL,ACADM,ETFA,ACOXL,IVD,ACOX3 |
| acyl-CoA oxidase activity | ACOXL,ACOX2 |
| FAD binding | DAO,DDO,DAO.1,AGPS,MICAL1,KMO,AIFM1,MICAL2B,PRODH,CYB5R3 |
| acyl-CoA dehydrogenase activity | ACOX3,ACAD8,ACOXL,ACADS,ACADM,ACAD9,ACADSB,ETFA,GCDHB,ACADVL |
| receptor binding | HCST,NCK1,PTPRD,WNT2BA,ARRB2,CCL13,FKBP1B,APP,ACOT2,NRXN1 |
| electron carrier activity | ALDH4A1,SRD5A1,SDHB,CYP19A1,ETFDH,PTGESL,ACADSB,AOX3,ADH5,ACOXL |
| palmitoyl-CoA oxidase activity | ACAA1A,ACAA1,ACOXL,ACADL |
| flavin adenine dinucleotide binding | NOS2,AOX3L1,IVD,MTRR,ACOXL,FMO1,MAOB,POR,AIFM4,TXNRD3 |
Interacting Protein
ACOX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACOX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACOX1.
UBA1;UBE2N;UBE2V1;midostaurin;TYSND1;PEX5;GABARAPL1;PEX14
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