ACOX1

  • Official Full Name

    acyl-CoA oxidase 1, palmitoyl
  • Overview

    The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified.
  • Synonyms

    ACOX1;acyl-CoA oxidase 1, palmitoyl;acyl Coenzyme A oxidase 1, palmitoyl;peroxisomal acyl-coenzyme A oxidase 1;PALMCOX;ACOX1_HUMAN;AOX;EC 1.3.3.6;Palmitoyl CoA oxidase;Palmitoyl-CoA oxidase;Peroxisomal acyl coenzyme A oxidase 1;SCOX;Straight chain acyl CoA oxidase;Straight-chain acyl-CoA oxidase;acyl-CoA oxidase, straight-chain;peroxisomal fatty acyl-CoA oxidase;acyl-Coenzyme A oxidase 1, palmitoyl;ACOX

Recombinant Proteins

  • Mouse
  • Chicken
  • Zebrafish
  • Human
  • Rhesus macaque
  • Rat
  • Mammalian Cells
  • Wheat Germ
  • Insect Cells
  • E.coli
  • In Vitro Cell Free System
  • HEK293
  • His
  • GST
  • Non
  • Avi
  • Fc
  • Myc
Cat.# Product name Source (Host) Species Tag Protein Length Price
ACOX1-1208M Recombinant Mouse ACOX1 Protein Mammalian Cells Mouse His
ACOX1-1354C Recombinant Chicken ACOX1 Mammalian Cells Chicken His
ACOX1-1467Z Recombinant Zebrafish ACOX1 Mammalian Cells Zebrafish His
ACOX1-172H Recombinant Human ACOX1 Protein, GST-Tagged Wheat Germ Human GST
ACOX1-214R Recombinant Rhesus monkey ACOX1 Protein, His-tagged Mammalian Cells Rhesus macaque His
ACOX1-2491H Recombinant Human ACOX1 protein(Met1-Leu660), His-tagged Insect Cells Human His Met1-Leu660
ACOX1-459R Recombinant Rat ACOX1 Protein Mammalian Cells Rat His
ACOX1-511HCL Recombinant Human ACOX1 cell lysate Insect Cells Human Non
ACOX1-0388H Recombinant Human ACOX1 Protein (Met1-Leu660 ), N-His-tagged E.coli Human His Met1-Leu660
ACOX1-0389H Recombinant Human ACOX1 Protein (Tyr275-Leu660), N-His-tagged E.coli Human His Tyr275-Leu660
ACOX1-10HF Recombinant Full Length Human ACOX1 Protein In Vitro Cell Free System Human Full L. 660 amino acids
ACOX1-115R Recombinant Rat ACOX1 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
ACOX1-115R-B Recombinant Rat ACOX1 Protein Pre-coupled Magnetic Beads HEK293 Rat
Acox1-2340M Recombinant Mouse Acox1 protein, His&Myc-tagged Insect Cells Mouse His&Myc 1-661aa
ACOX1-261M Recombinant Mouse ACOX1 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
ACOX1-261M-B Recombinant Mouse ACOX1 Protein Pre-coupled Magnetic Beads HEK293 Mouse
ACOX1-26477TH Recombinant Human ACOX1 Wheat Germ Human Non 660 amino acids
ACOX1-42R Recombinant Rhesus Macaque ACOX1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
ACOX1-42R-B Recombinant Rhesus Macaque ACOX1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
ACOX1-486H Recombinant Human ACOX1 Protein, His/GST-tagged E.coli Human GST&His Arg210~Asn409
Acox1-4887M Recombinant Mouse Acox1 protein, Myc-tagged E.coli Mouse Myc 1-661aa
ACOX1-794HF Recombinant Full Length Human ACOX1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 660 amino acids

    Involved Pathway

    ACOX1 involved in several pathways and played different roles in them. We selected most pathways ACOX1 participated on our site, such as Fatty acid degradation,alpha-Linolenic acid metabolism,Biosynthesis of unsaturated fatty acids, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACOX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    cAMP signaling pathway VAV3,PIK3CA,VIPR2,CNGA1,PDE3B,PIK3R2,HCAR3,FXYD1,HHIP,CALM4
    Fatty acid metabolism ACSL3B,MECR,ACAT2,CPT1B,PTPLAD1,HSD17B12,ACAA2,PPT2,PTPLA,CPT1A
    Biosynthesis of unsaturated fatty acids Scd2,FADS2,ACOT2,HSD17B12,ELOVL5,ACOX3,TECR,SCD5,HADHAB,HSD17B12B
    Fatty acid degradation ADH2-1,ALDH7A1,GCDH,ECI1,HADHA,ADH4,HADHAA,ALDH3A2A,ECI2,ACSBG1
    alpha-Linolenic acid metabolism PLA2G5,PLA2G1B,PLA2G2A,PLA2G2F,PLA2G2E,PLA2G12A,PLA2G4C,PLA2G2D,PLA2G10,PLA2G3
    Metabolic pathways UGT2B15,ALOX8,DAO,COX7C,PRODH2,ADK,ACMSD,GOT2,FAM213B,GPAT2
    PPAR signaling pathway SCD,ACSL1A,FABP1A,CYP8B1,HMGCS2,PCK1,ME1,ACADL,RXRA,MMP1
    Peroxisome ACSL5,PEX11B,DDO,ABCD1,ACSL1A,NOS2,ACAA1,XDH,PAOX,DAO.1

    Protein Function

    ACOX1 has several biochemical functions, for example, FAD binding,PDZ domain binding,acyl-CoA dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACOX1 itself. We selected most functions ACOX1 had, and list some proteins which have the same functions with ACOX1. You can find most of the proteins on our site.

    Function Related Protein
    PDZ domain binding CXXC4,LPAR2,ATP2B3A,PTEN,PLEKHA1,ATP2B1B,PTENB,SDC2,EXOC4,GRID2
    fatty-acyl-CoA binding ACBD4,ACBD5B,GCDHA,ACADSB,DBIL5,HMGCL,ACADVL,IVD,ACAD8,ACAD9
    acyl-CoA oxidase activity ACOXL,ACOX2
    protein N-terminus binding STXBP1,DCTN4,SNCA,PEX19,NFE2,ERCC2,PDCD10,GTF2H2,TP53,MYO7A
    receptor binding LTB,SMAGP,GNPAT,PGR,APLN,PTK2AB,MAG,Ifnl2,MCHR1,POMC
    acyl-CoA dehydrogenase activity GCDHA,ETFA,GCDHB,ACOXL,ACADSB,ACADVL,ACOX3,ACOX2,ACADM,ACAD8
    palmitoyl-CoA oxidase activity ACAA1,ACADL,ACOXL,ACAA1A
    flavin adenine dinucleotide binding MAOB,GFER,TXNRD1,ACADS,CYBB,PPOX,D2HGDH,NDOR1,DUS3L,SQLE
    electron carrier activity COX7A3,NDUFS2,GSR,GLRX2,ACOXL,ACADL,COX7A2A,PRKRA,ACADVL,HSD17B6

    Interacting Protein

    ACOX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACOX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACOX1.

    UBA1;UBE2N;UBE2V1;midostaurin;TYSND1;PEX5;GABARAPL1;PEX14

    Resources

    References

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