• Official Full Name

    ANGPTL4 angiopoietin-like 4

  • Background

    Angiopoietin-like protein 4 (ANGPTL4), also known as PPARγ angiopoietinrelated protein, fastinginduced adipose factor, or hepatic fibrinogen /angiopoietin-related protein (HFARP), is a secreted adipokine predominantly expressed in adipose tissue and liver. The experimental results show that ANGPTL4 is a blood-borne hormone directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. Serum levels of ANGPTL4 were decreased in patients with type 2 diabetes. In animal experiments, ANGPTL4 treatments might reduce hyperglycemia, and improve glucose tolerance by decreasing hepatic glucose production and enhancing insulin-mediated inhibition of gluconeogenesis. However, the molecular mechanisms underlying its metabolic actions remain elusive.
  • Synonyms

    ANGPTL4; angiopoietin-like 4; angiopoietin-related protein 4; angiopoietin related protein 4; ARP4; fasting induced adipose factor; FIAF; hepatic angiopoietin related protein; hepatic fibrinogen/angiopoietin related protein; HFARP; NL2; peroxisome proliferator activated receptor (PPAR) gamma induced angiopoietin related protein; PGAR; pp1158; PPARG angiopoietin related protein; angiopoietin-like protein 4; fasting-induced adipose factor; hepatic angiopoietin-related protein; hepatic fibrinogen/angiopoietin-related protein; peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin-related protein; ANGPTL2;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Cattle
    • Cynomolgus
    • Human
    • Macaca Fascicularis
    • Mouse
    • Pig
    • Rat
    • Zebrafish
    • Source :
    • CHO
    • COS-7 cells
    • E.coli
    • HEK293
    • Human Cell
    • In Vitro Cell Free System
    • Mammalian Cell
    • Mammalian cells
    • Wheat Germ
    • Tag :
    • DDK|His
    • Fc
    • Flag
    • FLAG
    • GST
    • His
    • His (Fc)
    • Avi
    • His|DDK
    • His|GST
    • His|T7
    • N/A
    • N
    Species Cat.# Product name Source (Host) Tag Price
    Human ANGPTL4-26H Active Recombinant Human ANGPTL4, His-tagged Mammalian cells His
    Human ANGPTL4-98H Active Recombinant Human ANGPTL4, FLAG-tagged HEK293 Flag
    Human ANGPTL4-160H Active Recombinant Human ANGPTL4 Protein, His-tagged, Biotinylated Mammalian cells His
    Human ANGPTL4-268H Active Recombinant Human ANGPTL4 protein, His-tagged CHO His
    Human ANGPTL4-159H Active Recombinant Human ANGPTL4 Protein, His-tagged, Biotinylated Mammalian cells His
    Human ANGPTL4-102H Recombinant Human ANGPTL4 Protein, FLAG-tagged HEK293 FLAG
    Human ANGPTL4-403H Recombinant Human ANGPTL4, Fibrinogen-like Domain, FLAG-tagged Human Cell Flag
    Human ANGPTL4-404H Recombinant Human Angiopoietin-like 4, His-tagged Mammalian Cell His
    Human ANGPTL4-5742H Recombinant Human ANGPTL4 protein, His & GST-tagged E.coli His/GST
    Human ANGPTL4-27H Recombinant Human ANGPTL4, GST-tagged Wheat Germ GST
    Human ANGPTL4-495H Recombinant Human ANGPTL4 Protein, His/DDK-tagged HEK293 His/DDK
    Human ANGPTL4-497H Recombinant Human ANGPTL4, His-tagged E.coli His
    Human ANGPTL4-430H Recombinant Human ANGPTL4 protein, His-tagged HEK293 His
    Human ANGPTL4-496H Recombinant Human ANGPTL4 Protein, DDK/His-tagged HEK293 DDK/His
    Human ANGPTL4-118H Recombinant Human Angiopoietin-like 4, His-tagged E.coli His
    Human ANGPTL4-557H Recombinant Human ANGPTL4 protein, GST-tagged Wheat Germ GST
    Human ANGPTL4-231H Recombinant Human ANGPTL4 Protein, Fc-tagged HEK293 Fc
    Human ANGPTL4-1097HCL Recombinant Human ANGPTL4 cell lysate Human Cell N/A
    Human ANGPTL4-091H Recombinant Human ANGPTL4 Protein, His-tagged HEK293 His
    Human ANGPTL4-4816H Recombinant Human ANGPTL4 protein, GST-tagged E.coli GST
    Human ANGPTL4-3223H Recombinant Human ANGPTL4 protein, His-tagged E.coli His
    Human ANGPTL4-232H Recombinant Human ANGPTL4(Phe20-Thr263) Protein, C-Fc-tagged HEK293 Fc
    Human ANGPTL4-2470H-B Recombinant Human ANGPTL4 Protein Pre-coupled Magnetic Beads HEK293
    Human ANGPTL4-0518H Recombinant Human ANGPTL4 Protein (His182-Tyr388), GST-tagged E.coli GST
    Human ANGPTL4-1271HF Recombinant Full Length Human ANGPTL4 Protein, GST-tagged In Vitro Cell Free System GST
    Human ANGPTL4-2470H Recombinant Human ANGPTL4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Human ANGPTL4-0519H Recombinant Human ANGPTL4 Protein (His182-Tyr388), N-GST-tagged E.coli N-GST
    Mouse Angptl4-105M Active Recombinant Mouse Angptl4, FLAG-tagged COS-7 cells Flag
    Mouse ANGPTL4-402M Recombinant Mouse Angiopoietin-like 4, Coiled-Coil Domain, His-tagged HEK293 His
    Mouse Angptl4-101M Recombinant Mouse Angptl4, FLAG-tagged HEK293 Flag
    Mouse Angptl4-405M Recombinant Mouse Angiopoietin-like 4, FLAG-tagged Mammalian Cell Flag
    Mouse Angptl4-406M Recombinant Mouse Angptl4, His-tagged E.coli N/A
    Mouse Angptl4-476M Recombinant Mouse Angptl4, His-tagged Human Cell His
    Mouse Angptl4-5743M Recombinant Mouse Angptl4 protein, His-tagged E.coli His
    Mouse ANGPTL4-746MCL Recombinant Mouse ANGPTL4 cell lysate Human Cell N/A
    Mouse Angptl4-153M Recombinant Mouse Angptl4 Protein, His-tagged E.coli N-His
    Rat Angptl4-104R Active Recombinant Rat Angptl4, His-tagged E.coli His
    Rat Angptl4-102R Recombinant Rat Angptl4, FLAG-tagged HEK293 Flag
    Rat Angptl4-5745R Recombinant Rat Angptl4 protein, His & T7-tagged E.coli His/T7
    Rat ANGPTL4-670R Recombinant Rat ANGPTL4 Protein Mammalian Cell His
    Rat ANGPTL4-326R Recombinant Rat ANGPTL4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rat ANGPTL4-326R-B Recombinant Rat ANGPTL4 Protein Pre-coupled Magnetic Beads HEK293
    Cattle ANGPTL4-5741C Recombinant Cattle ANGPTL4 protein, His-tagged E.coli His
    Cynomolgus ANGPTL4-129C Recombinant Cynomolgus ANGPTL4(Pro166-Ser406) Protein, N-10*His-tagged HEK293 His
    Macaca Fascicularis ANGPTL4-01H Recombinant Fibrinogen C-terminal domain of Macaca fascicularis Angiopoietin-like protein 4 Protein, his-tagged HEK293 His
    Zebrafish ANGPTL4-8125Z Recombinant Zebrafish ANGPTL4 Mammalian Cell His
    Pig ANGPTL4-5744P Recombinant Pig ANGPTL4 protein, His-tagged E.coli His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • ANGPTL4 Related Research Area

    ANGPTL4 involved in several pathways and played different roles in them. We selected most pathways ANGPTL4 participated on our site, such as PPAR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANGPTL4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    ANGPTL4 has several biochemical functions, for example, enzyme inhibitor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANGPTL4 itself. We selected most functions ANGPTL4 had, and list some proteins which have the same functions with ANGPTL4. You can find most of the proteins on our site.

    Function Related Protein
    enzyme inhibitor activitySLN;PLN;ANGPTL4;OAZ2A;TAE1;PPP1R12A;WDTC1;UGT1A1;KIAA1967

    ANGPTL4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANGPTL4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANGPTL4.


    • Q&As
    • Reviews

    Q&As (12)

    Ask a question
    Can ANGPTL4 be a potential target for drug development? 07/21/2022

    Yes, ANGPTL4 is considered a potential target for drug development. Inhibitors of ANGPTL4 have shown promise in preclinical studies for the treatment of lipid disorders, as they can increase lipoprotein lipase activity and reduce circulating triglyceride levels. Additionally, targeting ANGPTL4 in cancer therapy is being explored due to its involvement in tumor growth and metastasis. However, further research is needed to develop safe and effective drugs targeting ANGPTL4.

    Can ANGPTL4 protein be used as a potential biomarker? 06/15/2022

    Yes, ANGPTL4 protein has been explored as a potential biomarker in various diseases. Increased circulating levels of ANGPTL4 have been associated with obesity, insulin resistance, and metabolic disorders. ANGPTL4 levels have also been correlated with adverse lipid profiles and cardiovascular diseases. In cancer, ANGPTL4 expression and secretion have been linked to tumor progression and metastasis. However, further research is needed to determine the exact utility and significance of ANGPTL4 as a biomarker in different clinical settings.

    Are there any known mutations or polymorphisms in the ANGPTL4 gene that affect its function? 04/28/2022

    Yes, there are known mutations and polymorphisms in the ANGPTL4 gene that can affect its function. One well-studied mutation is the E40K variant, which results in a change in the amino acid at position 40 from glutamic acid (E) to lysine (K). This mutation leads to increased ANGPTL4 activity and is associated with lower levels of triglycerides and higher levels of high-density lipoprotein (HDL) cholesterol in the blood. Another variant, T266M, has also been identified and is associated with alterations in lipid metabolism. These genetic variations highlight the potential impact of ANGPTL4 gene mutations on metabolic traits.

    Can ANGPTL4 affect other metabolic pathways beyond lipid metabolism? 01/10/2022

    Yes, ANGPTL4 can affect other metabolic pathways beyond lipid metabolism. Apart from its well-established role in lipid metabolism, ANGPTL4 has been shown to regulate glucose metabolism, insulin sensitivity, and energy expenditure. ANGPTL4 can influence glucose uptake and insulin signaling in adipose tissue and skeletal muscles. It also affects the production and secretion of adipokines, such as adiponectin, which play a role in metabolic processes. ANGPTL4's involvement in various metabolic pathways highlights its complex role in maintaining metabolic homeostasis.

    Is ANGPTL4 protein involved in the regulation of appetite? 06/06/2021

    Yes, there is evidence to suggest that ANGPTL4 protein may play a role in appetite regulation. ANGPTL4 has been found to affect the release of gut hormones, such as ghrelin and glucagon-like peptide-1 (GLP-1), which are important regulators of appetite. Additionally, ANGPTL4 can modulate the activity of hypothalamic neurons involved in appetite control. However, the exact mechanisms underlying ANGPTL4's role in appetite regulation are still being investigated.

    What diseases or disorders are associated with ANGPTL4 protein? 01/30/2020

    ANGPTL4 has been implicated in several diseases and disorders. It is associated with obesity, insulin resistance, and metabolic syndrome. Additionally, ANGPTL4 is linked to various cancers, including breast, lung, and colorectal cancer, as it affects tumor growth, metastasis, and angiogenesis. ANGPTL4 is also connected to cardiovascular diseases and atherosclerosis.

    Are there any known interactions between ANGPTL4 and other proteins or molecules? 02/28/2019

    Yes, ANGPTL4 can interact with other proteins and molecules. For example, ANGPTL4 has been shown to interact with members of the integrin family, such as integrin alpha V beta 3 and integrin alpha 5. These interactions are important for ANGPTL4's involvement in angiogenesis and cell migration. ANGPTL4 can also interact with lipoprotein lipase (LPL), an enzyme involved in lipid metabolism, and regulate its activity. Additionally, ANGPTL4 can interact with extracellular matrix components, such as heparan sulfate proteoglycans, which can influence its localization and functions. The interactions between ANGPTL4 and other molecules contribute to its diverse biological roles.

    Does ANGPTL4 have any role in wound healing or tissue regeneration? 10/23/2018

    Yes, ANGPTL4 has been implicated in wound healing and tissue regeneration processes. ANGPTL4 is involved in angiogenesis, the formation of new blood vessels, which is crucial for wound healing. It promotes the migration and proliferation of endothelial cells, facilitating blood vessel formation. Additionally, ANGPTL4 has been shown to regulate tissue repair and remodeling in various organs, including the liver, skin, and intestines. However, further research is needed to fully understand the extent of ANGPTL4's role in these processes.

    Is ANGPTL4 involved in the development or progression of any specific diseases? 08/02/2017

    Yes, ANGPTL4 has been implicated in the development and progression of several diseases. It has been associated with obesity, insulin resistance, and metabolic disorders, such as type 2 diabetes and dyslipidemia. ANGPTL4 has also been found to play a role in cancer progression and metastasis, particularly in breast cancer and colorectal cancer. Additionally, ANGPTL4 has been linked to cardiovascular diseases, such as atherosclerosis and hypertension. Its involvement in these diseases highlights the multifaceted role of ANGPTL4 in various pathological processes.

    Are there any genetic mutations or variations known in the ANGPTL4 gene? 01/21/2017

    Yes, genetic variations in the ANGPTL4 gene have been identified. Certain single nucleotide polymorphisms (SNPs) in the ANGPTL4 gene are associated with altered circulating lipid levels, increased risk of obesity, insulin resistance, and cardiovascular diseases. These variations can impact ANGPTL4 protein expression or function.

    Is there ongoing research or clinical trials related to ANGPTL4? 08/25/2016

    Yes, there is ongoing research and clinical trials related to ANGPTL4. Scientists continue to study its role in lipid metabolism, obesity, cancer, and cardiovascular diseases. Clinical trials are investigating the therapeutic potential of targeting ANGPTL4 for the treatment of metabolic disorders and cancer. Monitoring scientific literature and clinical trial databases can provide more specific details about current research in this area.

    Are there any drugs or therapeutic interventions targeting ANGPTL4? 02/07/2016

    Yes, there are several drugs and therapeutic interventions that target ANGPTL4. One approach is the use of monoclonal antibodies that specifically bind to ANGPTL4 and inhibit its function. These antibodies have shown promise in reducing triglyceride levels and improving lipid profiles in preclinical studies. Another approach is the development of small molecule inhibitors that can target ANGPTL4 activity. These inhibitors have been shown to attenuate angiogenesis and tumor growth in cancer models. However, it is important to note that these interventions are still in the early stages of development and further research is needed before they can be used in clinical settings.

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