ANGPTL4

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ANGPTL4

Official Full Name ANGPTL4 angiopoietin-like 4
Background Angiopoietin-like protein 4 (ANGPTL4), also known as PPARγ angiopoietinrelated protein, fastinginduced adipose factor, or hepatic fibrinogen /angiopoietin-related protein (HFARP), is a secreted adipokine predominantly expressed in adipose tissue and liver. The experimental results show that ANGPTL4 is a blood-borne hormone directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. Serum levels of ANGPTL4 were decreased in patients with type 2 diabetes. In animal experiments, ANGPTL4 treatments might reduce hyperglycemia, and improve glucose tolerance by decreasing hepatic glucose production and enhancing insulin-mediated inhibition of gluconeogenesis. However, the molecular mechanisms underlying its metabolic actions remain elusive.
Synonyms ANGPTL4; angiopoietin-like 4; angiopoietin-related protein 4; angiopoietin related protein 4; ARP4; fasting induced adipose factor; FIAF; hepatic angiopoietin related protein; hepatic fibrinogen/angiopoietin related protein; HFARP; NL2; peroxisome proliferator activated receptor (PPAR) gamma induced angiopoietin related protein; PGAR; pp1158; PPARG angiopoietin related protein; angiopoietin-like protein 4; fasting-induced adipose factor; hepatic angiopoietin-related protein; hepatic fibrinogen/angiopoietin-related protein; peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin-related protein; ANGPTL2;
    • Species :
    • Cattle
    • Cynomolgus
    • Human
    • Mouse
    • Pig
    • Rat
    • Zebrafish
    • Source :
    • CHO
    • COS-7 cells
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian Cell
    • Mammalian cells
    • Wheat Germ
    • Tag :
    • DDK
    • His
    • Fc
    • Flag
    • GST
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Cynomolgus ANGPTL4-129C Recombinant Cynomolgus ANGPTL4(Glu74-Ser199) Protein, C-6*His-tagged HEK293 His
    Human ANGPTL4-232H Recombinant Human ANGPTL4(Phe20-Thr263) Protein, C-Fc-tagged HEK293 Fc
    Human ANGPTL4-102H Recombinant Human ANGPTL4 Protein, FLAG-tagged HEK293 FLAG
    Human ANGPTL4-1097HCL Recombinant Human ANGPTL4 cell lysate Human Cell N/A
    Human ANGPTL4-118H Recombinant Human Angiopoietin-like 4, His-tagged E.coli His
    Human ANGPTL4-159H Recombinant Human ANGPTL4 Protein, His-tagged, Biotinylated Mammalian cells His
    Human ANGPTL4-160H Recombinant Human ANGPTL4 Protein, His-tagged, Biotinylated Mammalian cells His
    Human ANGPTL4-231H Recombinant Human ANGPTL4 Protein, Fc-tagged HEK293 Fc
    Human ANGPTL4-268H Recombinant Human ANGPTL4 protein, His-tagged CHO His
    Human ANGPTL4-26H Recombinant Human ANGPTL4, His-tagged Mammalian cells His
    Human ANGPTL4-27H Recombinant Human ANGPTL4, GST-tagged Wheat Germ GST
    Human ANGPTL4-403H Recombinant Human ANGPTL4, Fibrinogen-like Domain, FLAG-tagged Human Cell Flag
    Human ANGPTL4-404H Recombinant Human Angiopoietin-like 4, His-tagged Mammalian Cell His
    Human ANGPTL4-430H Recombinant Human ANGPTL4 protein, His-tagged HEK293 His
    Human ANGPTL4-495H Recombinant Human ANGPTL4 Protein, His/DDK-tagged HEK293 His/DDK
    Human ANGPTL4-496H Recombinant Human ANGPTL4 Protein, DDK/His-tagged HEK293 DDK/His
    Human ANGPTL4-497H Recombinant Human ANGPTL4, His-tagged E.coli His
    Human ANGPTL4-557H Recombinant Human ANGPTL4 protein, GST-tagged Wheat Germ GST
    Human ANGPTL4-5742H Recombinant Human ANGPTL4 protein, His & GST-tagged E.coli His/GST
    Human ANGPTL4-98H Recombinant Human ANGPTL4, FLAG-tagged HEK293 Flag
    Mouse Angptl4-101M Recombinant Mouse Angptl4, FLAG-tagged HEK293 Flag
    Mouse Angptl4-105M Recombinant Mouse Angptl4, FLAG-tagged COS-7 cells Flag
    Mouse ANGPTL4-402M Recombinant Mouse Angiopoietin-like 4, Coiled-Coil Domain, His-tagged HEK293 His
    Mouse Angptl4-405M Recombinant Mouse Angiopoietin-like 4, FLAG-tagged Mammalian Cell Flag
    Mouse Angptl4-406M Recombinant Mouse Angptl4, His-tagged E.coli N/A
    Mouse Angptl4-476M Recombinant Mouse Angptl4, His-tagged Human Cell His
    Mouse Angptl4-5743M Recombinant Mouse Angptl4 protein, His-tagged E.coli His
    Mouse ANGPTL4-746MCL Recombinant Mouse ANGPTL4 cell lysate Human Cell N/A
    Rat Angptl4-102R Recombinant Rat Angptl4, FLAG-tagged HEK293 Flag
    Rat Angptl4-104R Recombinant Rat Angptl4, His-tagged E.coli His
    Rat Angptl4-5745R Recombinant Rat Angptl4 protein, His & T7-tagged E.coli His/T7
    Rat ANGPTL4-670R Recombinant Rat ANGPTL4 Protein Mammalian Cell His
    Zebrafish ANGPTL4-8125Z Recombinant Zebrafish ANGPTL4 Mammalian Cell His
    Cattle ANGPTL4-5741C Recombinant Cattle ANGPTL4 protein, His-tagged E.coli His
    Pig ANGPTL4-5744P Recombinant Pig ANGPTL4 protein, His-tagged E.coli His

    ANGPTL4 involved in several pathways and played different roles in them. We selected most pathways ANGPTL4 participated on our site, such as PPAR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANGPTL4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    PPAR signaling pathway ACOX1; ME1; MMP1; Scd2; SCP2A; PLTP; CD36; ACAA1A; PPARD; SLC27A4

    ANGPTL4 has several biochemical functions, for example, enzyme inhibitor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANGPTL4 itself. We selected most functions ANGPTL4 had, and list some proteins which have the same functions with ANGPTL4. You can find most of the proteins on our site.

    Function Related Protein
    enzyme inhibitor activity ANGPTL4; GCHFR; FRY; ATPIF1A; OAZ2A; PRPSAP1; CALU; UGT1A1; APBA3; HSPBP1
    protein binding FAM164A; GSTO1; ZNF473; PIKFYVE; F7; HPCAL1; OLIG1; FAM164C; FOSL2; STK10

    ANGPTL4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANGPTL4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANGPTL4.

    ITGB5; ITGB1; AURKA; TGFB1; ESR1; FGFR4; CDKN2A; CDKN2C; CASP8; FBXW7; BRMS1; RAC1; PTK2

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