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  • Official Full Name

    apolipoprotein C-III

  • Overview

    Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. It inhibits lipoprotein lipase and hepatic lipase and it is thought to delay catabolism of triglyceride-rich particles. An increase in apoC-III levels induces the development of hypertriglyceridemia.
  • Synonyms

    APOC3; apolipoprotein C-III; APOCIII; MGC150353; apo-CIII; apoC-III; apolipoprotein C3; OTTHUMP00000043270; OTTHUMP00000069353;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus monkey
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Human plasma
  • Human Plasma
  • In Vitro Cell Free System
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|SUMO
  • His|SUMOstar
  • SUMO
  • MBP
  • MYC
  • DDK
  • Myc|DDK
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human APOC3-393H Recombinant Human APOC3 protein, His/GST-tagged E.coli His/GST Ser21~Ala99
Human APOC3-706H Recombinant Human APOC3 protein, GST-tagged Wheat Germ GST
Human APOC3-392H Recombinant Human APOC3 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human APOC3-8782HCL Recombinant Human APOC3 293 Cell Lysate HEK293 N/A
Human APOC3-8040H Native Human ApoLipoprotein CIII Human Plasma N/A
Human APOC3-27333TH Native Human APOC3 N/A
Human ApoC-III-3559H Native Human ApoC-III Human plasma N/A
Human APOC3-361H Native Human Apolipoprotein C-III Human Plasma N/A
Human APOC3-669H Native Human APOC3 protein Human Plasma N/A
Human APOC3-4920HFL Recombinant Full Length Human APOC3 protein, Flag-tagged Mamanlian cells Flag
Human APOC3-2539H Recombinant Human APOC3 protein, His-SUMO-tagged E.coli His-SUMO 21-99aa
Human APOC3-1128HF Recombinant Full Length Human APOC3 Protein, GST-tagged In Vitro Cell Free System GST 99 amino acids
Human APOC3-0637H Recombinant Human APOC3 Protein (Ser21-Ala99), N-SUMO-tagged E.coli N-SUMO Ser21-Ala99
Human APOC3-0638H Recombinant Human APOC3 Protein, Tag Free E.coli Tag Free
Mouse Apoc3-1126M Recombinant Mouse Apoc3 Protein, His-SUMO-tagged E.coli His/SUMO
Mouse APOC3-1789M Recombinant Mouse APOC3 Protein Mammalian Cell His
Mouse Apoc3-1939M Recombinant Mouse Apoc3 protein, His-tagged E.coli His Glu21~Ser99
Mouse Apoc3-818M Recombinant Mouse Apoc3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse APOC3-635M Recombinant Mouse APOC3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse APOC3-635M-B Recombinant Mouse APOC3 Protein Pre-coupled Magnetic Beads HEK293
Rat Apoc3-1940R Recombinant Rat Apoc3 protein, His-tagged E.coli His Asp21~Pro101 (Accession # P06759)
Rat APOC3-1333R Recombinant Rat APOC3 Protein (21-101 aa), His-tagged Yeast His 21-101 aa
Cynomolgus monkey APOC3-2198C Recombinant Cynomolgus monkey APOC3 protein, MBP&His-tagged Insect Cell MBP&His 21-99aa
Cynomolgus Monkey APOC3-2235C Recombinant Cynomolgus Monkey APOC3 Protein (21-99 aa), His-SUMOSTAR-tagged Yeast His/SUMOstar 21-99 aa
Chicken APOC3-5614C Recombinant Chicken APOC3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

APOC3 involved in several pathways and played different roles in them. We selected most pathways APOC3 participated on our site, such as PPAR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with APOC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PPAR signaling pathwayCYP4A10;CYP8B1;SLC27A5;AQP7;UBC;ME1;FABP4;OLR1;ACSL3

APOC3 has several biochemical functions, for example, cholesterol binding, enzyme regulator activity, high-density lipoprotein particle receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APOC3 itself. We selected most functions APOC3 had, and list some proteins which have the same functions with APOC3. You can find most of the proteins on our site.

Function Related Protein
enzyme regulator activityCPN2;EIF2B1;GCLM;DCP1B;APOC3;PSMD3;BRCC3;DPM2;MTMR9
high-density lipoprotein particle receptor bindingAPOA2;APOC3;APOA1
lipase inhibitor activityAPOC2;APOC3;APOC1;FAF2;APOA2;APOA1
phospholipid bindingAGAP1;OSBPL1A;SHC1;PLA2G2A;ESYT1;BAD;RASAL1;APOA1;NUP35

APOC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APOC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of APOC3.

ARFGAP1; d-mannose; APOA1; ALB

  • Q&As
  • Reviews

Q&As (17)

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Are there any known methods to lower APOC3 levels in the body? 12/29/2022

Yes, there are several methods that have been shown to lower APOC3 levels in the body. Lifestyle changes such as regular exercise, a healthy diet, and weight loss can reduce APOC3 levels. Certain medications, such as fibrates and omega-3 fatty acids, have also been found to effectively decrease APOC3 levels. Additionally, emerging therapeutic approaches targeting APOC3, as mentioned earlier, are being developed to directly inhibit its production or activity.

Can lifestyle modifications, such as diet and exercise, help in managing elevated APOC3 protein levels? 11/30/2022

Yes, lifestyle modifications can help manage elevated APOC3 protein levels. A healthy diet low in saturated fats and refined carbohydrates, regular physical activity, and weight management can help control triglyceride levels and promote cardiovascular health.

Are there any support groups or resources available for individuals with APOC3-related conditions? 03/29/2022

While there may not be specific support groups solely dedicated to APOC3-related conditions, several organizations and resources focus on lipid disorders and cardiovascular health. The National Lipid Association and the American Heart Association are among the organizations that provide information, resources, and support for individuals and families impacted by lipid metabolism disorders.

Are there any specific targeted therapies being developed to reduce APOC3 levels? 07/09/2021

Yes, there are targeted therapies being developed to reduce APOC3 levels. One approach is the use of antisense oligonucleotides (ASOs), which are synthetic molecules designed to specifically target the APOC3 mRNA and inhibit its production. ASOs have shown promise in clinical trials, with some studies demonstrating significant reductions in APOC3 levels and improvements in lipid profiles. Another approach being explored is the use of gene editing technologies, such as CRISPR-Cas9, to directly modify the APOC3 gene and reduce its expression.

How is the APOC3 protein synthesized within the body? 02/12/2021

The APOC3 protein is primarily synthesized in the liver, but it can also be produced in the intestines. The APOC3 gene is transcribed into messenger RNA (mRNA), which is then translated in the cytoplasm of cells to ultimately produce the APOC3 protein.

Are there any known genetic mutations or variations in the APOC3 gene? 12/19/2020

Yes, variations in the APOC3 gene have been identified. Some mutations can lead to an increase in APOC3 protein levels, resulting in high triglyceride levels, which is a risk factor for cardiovascular disease.

Are there any known natural substances that can help reduce APOC3 levels? 08/08/2020

Some natural substances have shown potential in reducing APOC3 levels. For example, certain dietary components like polyphenols found in fruits, vegetables, and tea have been found to decrease APOC3 expression and inhibit its production. However, more research is needed to fully understand the effects and mechanisms of these natural substances on APOC3 levels.

Can mutations in the APOC3 gene lead to other health conditions besides FCS? 11/04/2019

Yes, mutations in the APOC3 gene have been associated with other health conditions besides FCS. Studies have identified APOC3 gene variants that are linked to increased risk of cardiovascular disease, metabolic disorders such as insulin resistance and type 2 diabetes, and non-alcoholic fatty liver disease.

Are there any potential side effects or risks associated with lowering APOC3 levels? 09/21/2019

While reducing APOC3 levels has shown promise in improving lipid profiles and reducing cardiovascular risk, there are potential side effects and risks to consider. Modulating APOC3 levels can affect lipid metabolism and may lead to changes in other lipoprotein components, including HDL (high-density lipoprotein) and LDL (low-density lipoprotein) cholesterol. This could potentially impact overall lipid balance and cardiovascular health.

Can genetic testing help identify individuals at risk of having elevated APOC3 levels? 07/03/2019

Yes, genetic testing can identify mutations in the APOC3 gene that may result in elevated APOC3 levels and increased triglyceride levels. Testing for these genetic variations can help identify individuals who are at a higher risk of developing conditions related to elevated APOC3 protein levels.

Are there any medications or drugs that target the APOC3 protein? 05/09/2019

There are ongoing research efforts to develop medications that target the APOC3 protein. One example is the drug known as volanesorsen, which is being investigated for its potential to lower triglyceride levels in individuals with specific genetic mutations.

How is APOC3 measured or tested in clinical settings? 05/21/2018

APOC3 levels can be measured or tested in clinical settings using various laboratory techniques. One common method is through the measurement of APOC3 concentration in blood samples using immunoassays, such as enzyme-linked immunosorbent assay (ELISA) or nephelometry. These techniques use specific antibodies that bind to APOC3 and allow for its quantification. Other methods, such as genetic testing or sequencing, can be used to identify mutations or genetic variants in the APOC3 gene that may affect APOC3 levels.

What are the potential consequences of elevated APOC3 protein levels? 04/09/2018

Elevated levels of APOC3 protein are associated with an increased risk of cardiovascular disease, as it can lead to high triglyceride levels and impaired lipid metabolism. This can contribute to the development of conditions like hypertriglyceridemia and may increase the risk of atherosclerosis.

Can APOC3 levels be used as a biomarker for certain diseases? 01/19/2017

APOC3 levels have been studied as potential biomarkers for various diseases. Elevated APOC3 levels have been associated with increased risk of cardiovascular disease, metabolic disorders, and non-alcoholic fatty liver disease. However, further research is needed to establish APOC3 levels as definitive biomarkers and to determine their clinical utility in diagnosing and monitoring these diseases.

Is there any connection between APOC3 and obesity? 01/07/2017

Yes, there is a connection between APOC3 and obesity. Obesity is often associated with elevated levels of triglycerides and APOC3, which can contribute to the development of metabolic disorders, insulin resistance, and cardiovascular disease. Therefore, reducing APOC3 levels may be beneficial in managing obesity-related health conditions.

Are there any known therapeutic approaches targeting APOC3 to reduce triglyceride levels? 06/30/2016

Yes, various therapeutic approaches are being explored to target APOC3 and lower triglyceride levels. These include the development of monoclonal antibodies, antisense oligonucleotides, and small interfering RNA (siRNA) therapies that specifically inhibit the production or activity of APOC3 protein.

Are there any other functions or roles of the APOC3 protein in the body? 06/11/2016

Apart from its role in lipid metabolism, the APOC3 protein has been implicated in other physiological processes. Studies suggest that it may have anti-inflammatory properties, play a role in regulating insulin sensitivity and glucose metabolism, and be involved in modulating the immune response.

Customer Reviews (4)

Write a review

    the manufacturer's supply management capabilities assure a seamless and continuous provision of the APOC3 protein.


      I am confident that the protein will reliably perform in my assays, providing accurate and reproducible results.


        the manufacturer's supply management capabilities assure a seamless and continuous provision of the APOC3 protein.


          Their ability to accommodate the requirements of large-scale experiments and guarantee a reliable supply streamlines my research operations, eliminating any concerns related to potential shortages.

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