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ARNT

  • Official Full Name

    aryl hydrocarbon receptor nuclear translocator

  • Overview

    The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor, and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1. A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Alternative splicing results in multiple transcript variants.
  • Synonyms

    ARNT; aryl hydrocarbon receptor nuclear translocator; bHLHe2; HIF 1beta; dioxin receptor, nuclear translocator; class E basic helix-loop-helix protein 2; hypoxia-inducible factor 1, beta subunit; HIF1B; TANGO; HIF1BETA; HIF-1beta; HIF1-beta; HIF-1-beta;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Klebsiella pneumoniae (strain 342)
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • E.coli expression system
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|S
  • His|T7
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ARNT-20H Recombinant Human ARNT, GST-tagged Wheat Germ GST
Human ARNT-32H Recombinant Human ARNT protein, His/S-tagged E.coli His/S
Human ARNT-3648H Recombinant Human ARNT, His-tagged E.Coli or Yeast His 773
Human ARNT-33H Recombinant Human ARNT protein, His-tagged Yeast His
Human ARNT-19H Recombinant Human ARNT, MYC/DDK-tagged HEK293 Myc/DDK
Human ARNT-8057H Recombinant Human ARNT protein, His & T7-tagged E.coli His/T7 Gln624~Glu789 (Accession # P27540)
Human ARNT-288H Recombinant Human ARNT protein, GST-tagged Insect Cell GST
Human ARNT-18H Recombinant Human ARNT, MYC/DDK-tagged HEK293 Myc/DDK
Human ARNT-8692HCL Recombinant Human ARNT 293 Cell Lysate HEK293 N/A
Human ARNT-1433HFL Recombinant Full Length Human ARNT, Flag-tagged Mamanlian cells Flag
Human ARNT-1740H Recombinant Human ARNT Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ARNT-3507H Recombinant Human ARNT Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ARNT-0377H Recombinant Human ARNT Protein (Met1-Ser348), N-His-tagged E.coli N-His Met1-Ser348
Mouse Arnt-3647M Recombinant Mouse Arnt, His-tagged E.Coli or Yeast His 791
Mouse ARNT-1961M Recombinant Mouse ARNT Protein Mammalian Cell His
Mouse ARNT-744M Recombinant Mouse ARNT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ARNT-744M-B Recombinant Mouse ARNT Protein Pre-coupled Magnetic Beads HEK293
Mouse Arnt-648M Recombinant Mouse Arnt Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat ARNT-794R Recombinant Rat ARNT Protein Mammalian Cell His
Rat ARNT-450R-B Recombinant Rat ARNT Protein Pre-coupled Magnetic Beads HEK293
Rat ARNT-450R Recombinant Rat ARNT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Homo sapiens (Human) RFL-1217HF Recombinant Full Length Human Aryl Hydrocarbon Receptor Nuclear Translocator(Arnt) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-789aa)
Klebsiella pneumoniae (strain 342) arnT-01K Recombinant Klebsiella pneumoniae (strain 342) arnT protein, His-tagged E.coli His 429-551aa
Zebrafish ARNT-1863Z Recombinant Zebrafish ARNT Mammalian Cell His
Chicken ARNT-5774C Recombinant Chicken ARNT Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ARNT Related Articles
  • ARNT Related Research Area

ARNT involved in several pathways and played different roles in them. We selected most pathways ARNT participated on our site, such as HIF- signaling pathway, Pathways in cancer, Chemical carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARNT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
HIF- signaling pathwayNOX1;TCEB2;GAPDH;ENO3;ANGPT4;MTOR;LTBR;PIK3R1;PIK3R5
Pathways in cancerAPPL1;SOS1;PIAS2;GNB4;WNT5B;CTNNA3;FAS;FASLG;RAC3
Chemical carcinogenesisGSTA1;SULT2A1;ALDH3B2;CHRNA7;CYP3A25;UGT2A1;ADH1C;HSD11B1;UGT1A6B
Renal cell carcinomaSLC2A1;RBX1;TGFB1;VEGFA;ETS1;ARAF;BRAF;PIK3R1;ARNT2

ARNT has several biochemical functions, for example, aryl hydrocarbon receptor activity, aryl hydrocarbon receptor binding, enhancer binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARNT itself. We selected most functions ARNT had, and list some proteins which have the same functions with ARNT. You can find most of the proteins on our site.

Function Related Protein
aryl hydrocarbon receptor activityAHR2;ARNT
aryl hydrocarbon receptor bindingAIP;ARNT;ARNT2;ARNTL
enhancer bindingLEF1;SOX9;FOXH1;SMAD2;AHR;SP1;TIPARP;ARNT;RAI1
protein bindingIQCB1;ARHGAP17;PPP1R1A;PPP1CC;ZFP423;BCKDHB;VTA1;DR1;FRMD4B
protein heterodimerization activityKATNB1;THRA;BIRC5;NKX2-5;FLOT2;ATF2;SCGB2A1;TLR1;TAF9
contributes_to sequence-specific DNA bindingHNRNPAB;EPAS1;HIF1A;TCF3;HDAC4;TRIM28;ARNT;PPARG;FIGLA
transcription coactivator activityRB1;NEUROG3;RNF4;PQBP1;UBE2L3;NFE2L3;MED21;BRD7;ARID1A
contributes_to transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingARNT;HIF1A
transcription factor activity, sequence-specific DNA bindingSCAND1;CITED2;ZNF548;TRPS1;UBN1;ZNF227;ZNF92;TRP63;MYCA
transcription factor bindingFIGLA;GATA4;PRICKLE1;CAMTA2;FHL2;SIRT1;PURB;PARK7;TWIST1

ARNT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARNT here. Most of them are supplied by our site. Hope this information will be useful for your research of ARNT.

HIF1A; AHR; NCOA7; NCOR2; Clock; SMAD9

Basham, KJ; Leonard, CJ; et al. Dioxin Exposure Blocks Lactation through a Direct Effect on Mammary Epithelial Cells Mediated by the Aryl Hydrocarbon Receptor Repressor. TOXICOLOGICAL SCIENCES 143:36-45(2015).
Kurita, H; Schnekenburger, M; et al. The Ah Receptor Recruits IKK alpha to Its Target Binding Motifs to Phosphorylate Serine-10 in Histone H3 Required for Transcriptional Activation. TOXICOLOGICAL SCIENCES 139:121-132(2014).
  • Q&As
  • Reviews

Q&As (23)

Ask a question
Is the ARNT protein primarily localized in the nucleus? 04/19/2023

The ARNT protein primarily localizes to the nucleus, where it functions as a transcription factor. However, under certain conditions, it can shuttle between the nucleus and cytoplasm, depending on the specific cellular signals and protein interactions involved.

Can the ARNT protein interact with other proteins? 11/18/2022

Yes, the ARNT protein can interact with various proteins, both within the cytoplasm and the nucleus. It forms heterodimers with partners like AhR, hypoxia-inducible factor (HIF), and hypoxia-responsive transcription factors, among others, to regulate gene expression.

How does the ARNT protein contribute to hypoxia adaptation? 01/18/2022

The ARNT protein is a key player in the cellular response to hypoxia (low oxygen levels). When oxygen levels are low, ARNT forms a complex with HIF-1α or HIF-2α, leading to the expression of genes involved in angiogenesis, erythropoiesis, and glucose metabolism, helping cells adapt and survive in oxygen-deprived environments.

What are the structural features of the ARNT protein? 10/05/2021

The ARNT protein belongs to the basic helix-loop-helix (bHLH) family of transcription factors. It contains multiple functional domains, including the bHLH domain, Per-ARNT-Sim (PAS) domains, and a transactivation domain for interacting with other transcriptional co-regulators.

Is ARNT expression altered in different tissues or cell types? 04/15/2021

Yes, the expression of ARNT can vary in different tissues and cell types. This can be due to tissue-specific transcriptional regulation, epigenetic modifications, and cell-specific signaling pathways. The expression and activity of ARNT can also be influenced by developmental stages and environmental factors.

Can ARNT play a role in immune response regulation? 08/09/2020

Yes, the ARNT protein can play a role in immune response regulation. It has been shown to be involved in the differentiation and function of immune cells, such as T cells and natural killer cells. ARNT can regulate the expression of genes involved in immune response pathways, including cytokine production and immune cell activation.

Can ARNT regulate the expression of its own gene? 06/14/2020

Yes, ARNT can regulate the expression of its own gene through a positive feedback loop. For example, the ARNT protein can bind to specific regulatory sequences in the ARNT gene promoter and enhance its own transcription, leading to increased ARNT expression.

Can ARNT be part of protein complexes other than those involving transcription factors? 04/30/2020

Yes, ARNT can participate in protein complexes other than those involving transcription factors. For example, it can form complexes with co-activators or co-repressors, chromatin remodeling proteins, and other regulatory proteins involved in transcriptional regulation or protein stability.

Does the ARNT protein have any role in drug metabolism? 08/13/2019

Yes, the ARNT protein is involved in the regulation of drug metabolism by modulating the expression of phase I and phase II drug-metabolizing enzymes and transporters.

What are some known transcription factors that interact with the ARNT protein? 04/02/2019

Some known transcription factors that interact with the ARNT protein include aryl hydrocarbon receptor (AhR), hypoxia-inducible factor (HIF), hypoxia-responsive transcription factors (HRTFs), and estrogen receptor alpha (ERα).

Are there any drugs that target the ARNT protein? 03/14/2019

Currently, there are no specific drugs available that directly target the ARNT protein. However, research is ongoing to identify compounds and strategies that can modulate ARNT activity and downstream gene expression for potential therapeutic purposes.

What are the physiological processes influenced by the ARNT protein? 02/14/2019

The ARNT protein plays a crucial role in diverse physiological processes. It has been implicated in the regulation of xenobiotic metabolism, response to environmental toxins, development of vascular and respiratory systems, immune response, and adaptation to hypoxia.

Are there any diseases associated with dysfunctional ARNT protein? 08/25/2018

Dysregulation or mutation of the ARNT protein has been linked to several diseases, including various cancers, metabolic disorders, and developmental abnormalities.

Are there any diseases or conditions associated with dysregulation of ARNT? 08/23/2018

Dysregulation of ARNT has been implicated in various diseases and conditions. For example, alterations in ARNT expression or activity can contribute to metabolic disorders like obesity and diabetes. Dysregulated ARNT signaling has also been linked to certain cancers, cardiovascular diseases, and neurodegenerative disorders.

Can ARNT be regulated by small molecules or environmental factors? 08/18/2018

Yes, ARNT can be regulated by small molecules and environmental factors. For example, the activity of ARNT can be modulated by ligands that bind to its interacting partner, such as the aryl hydrocarbon receptor (AhR). Environmental pollutants, such as dioxins and polycyclic aromatic hydrocarbons (PAHs), can bind to AhR and indirectly affect ARNT activity.

Can the ARNT protein play a role in cancer development? 08/06/2018

Yes, dysregulation of the ARNT protein has been implicated in various cancers. It can influence tumor growth, angiogenesis, and drug resistance through its interactions with other transcription factors, such as HIF-1α and AhR, and the modulation of downstream target genes involved in these processes.

Can the ARNT protein be modified by phosphorylation? 07/30/2018

Yes, the ARNT protein can undergo phosphorylation, which can impact its stability, activity, and interactions with other proteins. Phosphorylation events influenced by various kinases can regulate the function of ARNT in different cellular contexts.

What are some additional roles of the ARNT protein in development? 02/25/2018

Besides its involvement in the development of the vascular and respiratory systems, the ARNT protein also plays a role in embryonic development, including organogenesis, neural development, and placental development. It regulates the expression of genes essential for proper development during these processes.

Does ARNT have any role in oxidative stress response? 02/17/2018

Yes, ARNT plays a role in oxidative stress response. It can regulate the expression of genes involved in antioxidant defense mechanisms, such as the expression of enzymes involved in detoxification processes and protection against reactive oxygen species (ROS).

Can ARNT interact with other proteins or factors not mentioned earlier? 08/20/2017

Yes, in addition to AhR and HIF, ARNT can interact with a wide range of other proteins and transcription factors. Some examples include p53, NF-κB, c-Myc, STAT3, and Nrf2. These interactions contribute to the diverse functions of ARNT in different cellular processes and signaling pathways.

Can the ARNT protein be targeted for therapeutic interventions? 08/17/2016

Given its involvement in various diseases and its role in regulating gene expression, the ARNT protein is an attractive target for therapeutic interventions. However, more research is needed to explore specific strategies and compounds that can modulate its activity.

Are there any inherited disorders associated with ARNT protein mutations? 05/08/2016

Yes, mutations in the ARNT gene have been associated with a few inherited disorders. For example, some individuals with a rare genetic disorder called aryl hydrocarbon receptor deficiency (AHRD) have mutations in the ARNT gene, leading to impaired AhR signaling and dysfunctional immune response.

Can the ARNT protein influence cellular metabolism? 02/20/2016

Yes, the ARNT protein plays a role in cellular metabolism by regulating the expression of genes involved in xenobiotic metabolism, energy metabolism, and lipid metabolism. It can impact the activity of drug-metabolizing enzymes and certain metabolic pathways under various environmental and physiological conditions.

Customer Reviews (6)

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Reviews
07/03/2022

    This protein demonstrates great performance in WB assays, providing accurate and reliable results that are crucial for protein analysis.

    11/16/2021

      Incorporating this protein into scientific investigations undoubtedly enhances the reliability and effectiveness of research endeavors.

      06/17/2019

        The ARNT protein is highly recommended for researchers conducting protein studies, especially in Western blotting (WB) experiments.

        02/04/2019

          the ARNT protein has proven to be an invaluable tool in protein electron microscopy (EM) structure analysis.

          10/26/2018

            Whether investigating metabolic pathways, studying enzymatic activity, or exploring drug targets, this protein offers versatility and reliability, allowing for accurate and meaningful data collection.

            07/24/2018

              This level of support instills trust and confidence in the product, facilitating smooth and successful experimentation.

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