Recombinant Human ARNT, His-tagged
Cat.No. : | ARNT-3648H |
Product Overview : | Aryl hydrocarbon receptor nuclear translocator (ARNT) |
- Specification
- Gene Information
- Related Products
Description : | The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor, and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1. A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Alternative splicing results in multiple transcript variants. |
Source : | E. Coli or Yeast |
Species : | Human |
Tag : | His |
Form : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Protein length : | 773 |
Purity : | >90% |
Notes : | Small volumes of ARNT recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice. |
Storage : | Store at -20 degree C. For extended storage, store at -20 or -80 degree C. |
Storage Buffer : | PBS pH 7.4, 50% glycerol |
Warning : | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Gene Name : | ARNT aryl hydrocarbon receptor nuclear translocator [ Homo sapiens ] |
Official Symbol : | ARNT |
Synonyms : | ARNT; aryl hydrocarbon receptor nuclear translocator; bHLHe2; HIF 1beta; dioxin receptor, nuclear translocator; class E basic helix-loop-helix protein 2; hypoxia-inducible factor 1, beta subunit; HIF1B; TANGO; HIF1BETA; HIF-1beta; HIF1-beta; HIF-1-beta; |
Gene ID : | 405 |
mRNA Refseq : | NM_001197325 |
Protein Refseq : | NP_001184254 |
MIM : | 126110 |
UniProt ID : | P27540 |
Chromosome Location : | 1q21 |
Pathway : | Angiogenesis, organism-specific biosystem; HIF-1-alpha transcription factor network, organism-specific biosystem; HIF-2-alpha transcription factor network, organism-specific biosystem; Hypoxic and oxygen homeostasis regulation of HIF-1-alpha, organism-spe |
Function : | aryl hydrocarbon receptor activity; aryl hydrocarbon receptor binding; protein binding; protein heterodimerization activity; contributes_to sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; contributes_to sequence-specific distal enhancer binding RNA polymerase II transcription factor activity; signal transducer activity; transcription coactivator activity; transcription factor binding; |
Products Types
◆ Recombinant Protein | ||
ARNT-744M | Recombinant Mouse ARNT Protein, His (Fc)-Avi-tagged | +Inquiry |
Arnt-648M | Recombinant Mouse Arnt Protein, MYC/DDK-tagged | +Inquiry |
ARNT-450R | Recombinant Rat ARNT Protein, His (Fc)-Avi-tagged | +Inquiry |
ARNT-18H | Recombinant Human ARNT, MYC/DDK-tagged | +Inquiry |
ARNT-33H | Recombinant Human ARNT protein, His-tagged | +Inquiry |
◆ Lysates | ||
ARNT-8692HCL | Recombinant Human ARNT 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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