Description : |
This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
86.5 kDa |
AA Sequence : |
MAATTANPEMTSDVPSLGPAIASGN SGPGIQGGGAIVQRAIKRRPGLDFD DDGEGNSKFLRCDDDQMSNDKERFA RSDDEQSSADKERLARENHSEIERR RRNKMTAYITELSDMVPTCSALARK PDKLTILRMAVSHMKSLRGTGNTST DGSYKPSFLTDQELKHLILEAADGF LFIVSCETGRVVYVSDSVTPVLNQP QSEWFGSTLYDQVHPDDVDKLREQL STSENALTGRILDLKTGTVKKEGQQ SSMRMCMGSRRSFICRMRCGSSSVD PVSVNRLSFVRNRCRNGLGSVKDGE PHFVVVHCTGYIKAWPPAGVSLPDD DPEAGQGSKFCLVAIGRLQVTSSPN CTDMSNVCQPTEFISRHNIEGIFTF VDHRCVATVGYQPQELLGKNIVEFC HPEDQQLLRDSFQQVVKLKGQVLSV MFRFRSKNQEWLWMRTSSFTFQNPY SDEIEYIICTNTNVKNSSQEPRPTL SNTIQRPQLGPTANLPLEMGSGQLA PRQQQQQTELDMVPGRDGLASYNHS QVVQPVTTTGPEHSKPLEKSDGLFA QDRDPRFSEIYHNINADQSKGISSS TVPATQQLFSQGNTFPPTPRPAENF RNSGLAPPVTIVQPSASAGQMLAQI SRHSNPTQGATPTWTPTTRSGFSAQ QVATQATAKTRTSQFGVGSFQTPSS FSSMSLPGAPTASPGAAAYPSLTNR GSNFAPETGQTAGQFQTRTAEGVGV WPQWQGQQPHHRSSSSEQHVQQPPA QQPGQPEVFQEMLSMLGDQSNSYNN EEFPDLTMFPPFSETRTRPLEQKLI SEEDLAANDILDYKDDDDKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |