ASCL1
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Official Full Name
achaete-scute family bHLH transcription factor 1
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Overview
This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5-CANNTG-3). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases. [provided by RefSeq, Jul 2008] -
Synonyms
ASCL1; achaete-scute family bHLH transcription factor 1; ASH1; HASH1; MASH1; bHLHa46; achaete-scute homolog 1; ASH-1; achaete scute protein; achaete-scute complex-like 1; achaete-scute complex homolog 1; class A basic helix-loop-helix protein 46;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E. coli
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Arg
- Flag
- GST
- His
- Fc
- Avi
- Myc
- DDK
- N
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
ASCL1 involved in several pathways and played different roles in them. We selected most pathways ASCL1 participated on our site, such as Delta-Notch Signaling Pathway, Neural Crest Differentiation, Notch-mediated HES/HEY network, which may be useful for your reference. Also, other proteins which involved in the same pathway with ASCL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Delta-Notch Signaling Pathway | ASCL1;TCF3B;HES6;CNTN1B;YY1A;APPA;MAGEA1;CNTN1;CNTF |
| Neural Crest Differentiation | MBP;PRTG;PMP22;DLX5;MIA;PHOX2B;SOX5;LHX1;TFAP2B |
| Notch-mediated HES/HEY network | RCAN1;BGLAP;HEY1;ASCL1;GATA6;CTBP1;GATA1;TLE1;HES6 |
| SIDS Susceptibility Pathways | POU3F2;POU2F2;DEAF1;GATA2;MBD1;FOXM1;TSPYL1;CHRFAM7A;TPH2 |
ASCL1 has several biochemical functions, for example, DNA binding, E-box binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ASCL1 itself. We selected most functions ASCL1 had, and list some proteins which have the same functions with ASCL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | NKX2.9;SPI1A;ZFP692;BANP;SPI1B;DMRT3;BSX;PHC2;NUCB1 |
| E-box binding | ASCL2;GATA3;NEUROD2;TWIST1;MYC;TCF21;ZEB1;NEUROD1;AHR |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | FOXK2;SREBF1;HLTF;MZF1;KCNIP3;IFI16;ELF3;MYF5;MIXL1 |
| bHLH transcription factor binding | SOX9;SMAD3;SIRT1;SP1;MAP3K10;TWIST1;USF2;ASCL1;USF1 |
| chromatin binding | ELK4;CBX5;CREB3;HMGB3;PAF1;ISL1;BEND6;ING5;CHD7 |
| protein binding | ARAP1;TGFBR2;FUBP3;MSH4;SGK1;PPP2R1A;TFF3;ARMC7;PUF60 |
| protein homodimerization activity | RRAGA;CARS;BHLHE40;MYOM3;AMICA1;BAK1;SRGAP2;STK25;CPOX |
| transcription factor activity, sequence-specific DNA binding | CHES1;ZFP583;HOXB2A;Trl;ZFP260;TFDP1;NFE2L2A;DMRTC1B;ZNF232 |
| transcription factor activity, transcription factor binding | ASCL1B;PER2;CRY1;MTA2;LDB2B;TP63;FOXO1;HIF1A;LDB1A |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | SNAI1;PROX1;KLF16;ATF7;FOXO1;GZF1;POU4F2;TGIF1;NKX3-2 |
ASCL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASCL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ASCL1.
TCF4; TCF3; dna-1
Research Area
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Customer Reviews (3)
Write a reviewTheir collaboration, expertise, and customized solutions contribute to the successful execution of experiments, reliable data generation, and the advancement of scientific knowledge in the field.
the manufacturer's support is crucial for researchers using ASCL1 protein in trials.
They may offer educational resources such as technical guides, protocols, and application notes, which can aid researchers in understanding the principles, techniques, and potential applications of ASCL1 protein in their studies.
Q&As (8)
Ask a questionYes, ASCL1 is associated with several human diseases, including neuroblastoma and small cell lung cancer, where it is often overexpressed and contributes to tumor development.
Yes, ASCL1 is a key regulator of neurogenesis. It acts as a transcription factor that directs the differentiation of neural stem cells into neurons during development.
Yes, ASCL1, in combination with other transcription factors, can induce the reprogramming of somatic cells into neurons in vitro, demonstrating its ability to change cell fate.
Yes, ASCL1 is critical for the formation of several neuronal subtypes, including subtypes in the cerebral cortex, olfactory bulb, and autonomic ganglia.
Although ASCL1 is primarily associated with neural development, it is also expressed in specific regions of the developing lung, where it influences lung neuroendocrine cell differentiation.
ASCL1 is actively being researched as a potential therapeutic target in neuroblastoma and small cell lung cancer. Developing drugs that inhibit ASCL1 may help treat these diseases.
While ASCL1's role in adult neurogenesis is not fully understood, studies suggest that it may play a role in the generation of newborn neurons in certain brain regions, such as the olfactory bulb.
ASCL1 interacts with various proteins involved in neural development and transcriptional regulation, including NEUROD1, TCF3, TLE1, and HDAC1.
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