ASCL1

  • Official Full Name

    achaete-scute family bHLH transcription factor 1

  • Overview

    This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5-CANNTG-3). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases. [provided by RefSeq, Jul 2008]
  • Synonyms

    ASCL1; achaete-scute family bHLH transcription factor 1; ASH1; HASH1; MASH1; bHLHa46; achaete-scute homolog 1; ASH-1; achaete scute protein; achaete-scute complex-like 1; achaete-scute complex homolog 1; class A basic helix-loop-helix protein 46;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E. coli
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Arg
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ASCL1-22H Recombinant Human ASCL1 protein, His-tagged E.coli His 251aa(including fusion tag)
Human ASCL1-28522TH Recombinant Human ASCL1 Wheat Germ N/A 100 amino acids
Human ASCL1-131H Recombinant Human ASCL1 protein, Arginine-tagged E.coli Arg
Human ASCL1-901H Recombinant Human ASCL1 protein, GST-tagged Wheat Germ GST
Human ASCL1-8654HCL Recombinant Human ASCL1 293 Cell Lysate HEK293 N/A
Human ASCL1-23H Recombinant Human ASCL1 Protein, His-tagged E. coli His Lys84~Phe236
Human ASCL1-386H Recombinant Human ASCL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ASCL1-1999H Recombinant Human ASCL1 protein, His-tagged E.coli His 1-236aa
Human ASCL1-1021HF Recombinant Full Length Human ASCL1 Protein, GST-tagged In Vitro Cell Free System GST 236 amino acids
Human ASCL1-4032H Recombinant Human ASCL1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ASCL1-386H-B Recombinant Human ASCL1 Protein Pre-coupled Magnetic Beads HEK293
Human ASCL1-754HFL Recombinant Full Length Human ASCL1 Protein, C-Flag-tagged Mammalian cells Flag
Mouse ASCL1-2025M Recombinant Mouse ASCL1 Protein Mammalian Cell His
Mouse ASCL1-784M-B Recombinant Mouse ASCL1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Ascl1-1739M Recombinant Mouse Ascl1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse ASCL1-784M Recombinant Mouse ASCL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Ascl1-3064R Recombinant Rat Ascl1, His-tagged E.Coli or Yeast His 233
Rat ASCL1-818R Recombinant Rat ASCL1 Protein Mammalian Cell His
Rat ASCL1-474R Recombinant Rat ASCL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ASCL1-474R-B Recombinant Rat ASCL1 Protein Pre-coupled Magnetic Beads HEK293
Chicken ASCL1-5982C Recombinant Chicken ASCL1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ASCL1 Related Articles
  • ASCL1 Related Research Area

ASCL1 involved in several pathways and played different roles in them. We selected most pathways ASCL1 participated on our site, such as Delta-Notch Signaling Pathway, Neural Crest Differentiation, Notch-mediated HES/HEY network, which may be useful for your reference. Also, other proteins which involved in the same pathway with ASCL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Delta-Notch Signaling PathwayCNTN1;NOV;ASCL1;RING1;APPA;CNTN1B;HIVEP3;YY1A;HES6
Neural Crest DifferentiationMYB;TBX6;HOXA1;CDH7;OLIG1;PHOX2B;LHX1;DMBX1;TCF4
Notch-mediated HES/HEY networkMYOD1;YY1;GATA1;BGLAP;HES6;MYB;ASCL1;GATA6;RCAN1
SIDS Susceptibility PathwaysPHOX2B;YBX1;POU3F2;KCNJ8;EN1;MECP2;TPPP;SST;TSPYL1

ASCL1 has several biochemical functions, for example, DNA binding, E-box binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ASCL1 itself. We selected most functions ASCL1 had, and list some proteins which have the same functions with ASCL1. You can find most of the proteins on our site.

Function Related Protein
DNA bindingHOXA5;RXRAB;FOXG1C;CHST13;ELF2A;TFIP11;E4F1;ZNF398;HOXA4A
E-box bindingNEUROD1;TAL1;GATA3;ARNTL;NEUROD2;ASCL2;LMO2;AHR;ZEB1
RNA polymerase II core promoter proximal region sequence-specific DNA bindingNR6A1;NKX2-8;POU2F2;SIX1;NEUROG3;ZNF486;KLF16;MYPOP;FOS
bHLH transcription factor bindingTCF3A;TCF3B;RUNX2;TCF12;ISL1;IKZF4;SIRT1;SOX9;USF1
chromatin bindingRAG2;NFKB2;NCOA2;WDHD1;PYGO2;APTX;BRD3;MBD1;ARX
protein bindingGYPC;ANLN;HOXA9;CYB5R1;NEUROG1;MOB4;IL6R;HHIP;SAMHD1
protein homodimerization activityBCL2;GJC3;PDCD6;TERT;MZF1;APOC2;ADD2;PLEK;SLK
transcription factor activity, sequence-specific DNA bindingTFDP1B;ZFP82;TBX5A;SFPI1;TGIF1;HLFA;PBX1;STAT1B;ZNF484
transcription factor activity, transcription factor bindingPER2;LDB1A;CRY1;MTA2;PER1;HIF1A;LDB2A;LDB1B;ASCL1
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific bindingBTG2;NR2E1;SP3;E2F8;CREBBP;NFIL3-4;SNAI2;RELA;RCOR1

ASCL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASCL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ASCL1.

TCF4; TCF3; dna-1

Karow, M; Schichor, C; et al. Lineage-reprogramming of Pericyte-derived Cells of the Adult Human Brain into Induced Neurons. Jove-Journal of Visualized Experiments :-(2014).
Teicher, BA; et al. Targets in small cell lung cancer. BIOCHEMICAL PHARMACOLOGY 87:211-219(2014).
  • Q&As
  • Reviews

Q&As (8)

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Is ASCL1 associated with any human diseases? 07/21/2020

Yes, ASCL1 is associated with several human diseases, including neuroblastoma and small cell lung cancer, where it is often overexpressed and contributes to tumor development.

Is ASCL1 involved in neurogenesis? 12/13/2019

Yes, ASCL1 is a key regulator of neurogenesis. It acts as a transcription factor that directs the differentiation of neural stem cells into neurons during development.

Can ASCL1 promote cellular reprogramming? 07/24/2019

Yes, ASCL1, in combination with other transcription factors, can induce the reprogramming of somatic cells into neurons in vitro, demonstrating its ability to change cell fate.

Is ASCL1 important for the formation of specific neuronal subtypes? 05/22/2018

Yes, ASCL1 is critical for the formation of several neuronal subtypes, including subtypes in the cerebral cortex, olfactory bulb, and autonomic ganglia.

Does ASCL1 have any role in non-neuronal tissues? 11/24/2017

Although ASCL1 is primarily associated with neural development, it is also expressed in specific regions of the developing lung, where it influences lung neuroendocrine cell differentiation.

Can ASCL1 be targeted for therapeutic interventions or drug discovery? 04/01/2017

ASCL1 is actively being researched as a potential therapeutic target in neuroblastoma and small cell lung cancer. Developing drugs that inhibit ASCL1 may help treat these diseases.

Does ASCL1 have a role in adult neurogenesis? 10/01/2016

While ASCL1's role in adult neurogenesis is not fully understood, studies suggest that it may play a role in the generation of newborn neurons in certain brain regions, such as the olfactory bulb.

What are the known interacting partners of ASCL1? 06/09/2016

ASCL1 interacts with various proteins involved in neural development and transcriptional regulation, including NEUROD1, TCF3, TLE1, and HDAC1.

Customer Reviews (3)

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Reviews
08/14/2022

    Their collaboration, expertise, and customized solutions contribute to the successful execution of experiments, reliable data generation, and the advancement of scientific knowledge in the field.

    10/15/2019

      the manufacturer's support is crucial for researchers using ASCL1 protein in trials.

      02/22/2019

        They may offer educational resources such as technical guides, protocols, and application notes, which can aid researchers in understanding the principles, techniques, and potential applications of ASCL1 protein in their studies.

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