ATP6V1A

Official Full Name

ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
Overview

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of;eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular;processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient;generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of;three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP;catalytic site. The V0 domain consists of five different subunits: a, c, c, c, and d. Additional isoforms of many of;the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This;encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues. Transcript variants derived;from alternative polyadenylation exist.
Synonyms

ATP6V1A; ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A; ATP6A1, ATP6V1A1, ATPase, H+ transporting, lysosomal (vacuolar proton pump), alpha polypeptide, 70kD, isoform 1 , VPP2; V-type proton ATPase catalytic subunit A; VA68; Vma1; V-ATPase subuni;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rhesus Macaque

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ATP6V1A-1000H	Recombinant Human ATP6V1A protein, GST-tagged	Wheat Germ	GST		$498 / 2µg
Human	ATP6V1A-10040H	Recombinant Human ATP, His-tagged	E.coli	His	268-617a.a.	$319 / 25μg
Human	ATP6V1A-8585HCL	Recombinant Human ATP6V1A 293 Cell Lysate	HEK293	Non		Inquiry
Human	ATP6V1A-1500HF	Recombinant Full Length Human ATP6V1A Protein, GST-tagged	In Vitro Cell Free System	GST	617 amino acids	Inquiry
Mouse	ATP6V1A-2158M	Recombinant Mouse ATP6V1A Protein	Mammalian Cell	His		Inquiry
Mouse	ATP6V1A-875M	Recombinant Mouse ATP6V1A Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Mouse	ATP6V1A-875M-B	Recombinant Mouse ATP6V1A Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	ATP6V1A-466R	Recombinant Rhesus monkey ATP6V1A Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	ATP6V1A-295R	Recombinant Rhesus Macaque ATP6V1A Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Rhesus Macaque	ATP6V1A-295R-B	Recombinant Rhesus Macaque ATP6V1A Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	ATP6V1A-6533C	Recombinant Chicken ATP6V1A	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

ATP6V1A involved in several pathways and played different roles in them. We selected most pathways ATP6V1A participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6V1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Oxidative phosphorylation	NDUFA8;NDUFA1;NDUFA6;NDUFA3;NDUFA9A;ATP5I;UQCRC2A;UQCRB;COX4I2
Metabolic pathways	PIP5K1B;AUH;DHCR7;DGKD;INPP5L;MOCS1;COX5B;BCO1L;PSAT1
Phagosome	TUBA1A;cgr2b;ATP6V1C1A;TUBB6;ACTB1;BLB1;ATP6V0E;HLA-DRB1;TUBA4L
Synaptic vesicle cycle	STX2;ATP6V1G1;UNC13C;ATP6V1E1;SLC17A7;ATP6V0A1;STX1B;SYT1;ATP6V1B1
Collecting duct acid secretion	CA2;TCIRG1;ATP6V1E1;ATP6V0A2;ATP4B;CLCNKB;ATP6V1G1;SLC4A1;ATP6V1C1
Vibrio cholerae infection	KDELR3;ATP6V1B2;ACTB;PLCG1;ATP6V1H;ATP6V1F;ATP6AP1;ATP6V1A;ATP6V0A4
Epithelial cell signaling in Helicobacter pylori infection	ATP6V1D;ATP6V0C;MAPK12;LYN;ATP6V0A1;ATP6V1E2;ATP6V1F;ATP6V1H;CCL5
Rheumatoid arthritis	TNFRSF11A;ATP6V0C;Ccl12;ATP6V0B;IFNG;Il23a; Il12b;HLA-DOB;HLA-DPA1;GM-CSF

ATP6V1A has several biochemical functions, for example, ATP binding, proton-transporting ATPase activity, rotational mechanism. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6V1A itself. We selected most functions ATP6V1A had, and list some proteins which have the same functions with ATP6V1A. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	MKKS;CLCN5;FES;TSSK1;PIKFYVE;MLH3;RECQL;PCCA;MAPK11
proton-transporting ATPase activity, rotational mechanism	ATP6V0A1B;TCIRG1;ATP6V1H;ATP6V0A2B;ATP5E;ATP6V0E;ATP6AP1;ATP6V1E2;ATP6V1E1B

ATP6V1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6V1A here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6V1A.

CHMP4B; HLA-B; TK1; ANXA7; CDKN1A; SMN1; b4e1j8_human; b7z6l9_human; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; pi3p; 15-deoxy-delta(12,14; FLOT2; CALM1; e9pbb7_human; Flot1; TM9SF1; MYO1B; DNAJC13

Research Area

Peinado, MA; Hernandez, R; et al. Proteomic characterization of nitrated cell targets after hypobaric hypoxia and reoxygenation in rat brain. JOURNAL OF PROTEOMICS 109:309-321(2014).

Alzamora, R; Al-Bataineh, MM; et al. AMP-activated protein kinase regulates the vacuolar H+-ATPase via direct phosphorylation of the A subunit (ATP6V1A) in the kidney. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 305:F943-F956(2013).