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Official Full Name ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
Background This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of;eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular;processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient;generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of;three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP;catalytic site. The V0 domain consists of five different subunits: a, c, c, c, and d. Additional isoforms of many of;the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This;encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues. Transcript variants derived;from alternative polyadenylation exist.
Synonyms ATP6V1A; ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A; ATP6A1, ATP6V1A1, ATPase, H+ transporting, lysosomal (vacuolar proton pump), alpha polypeptide, 70kD, isoform 1 , VPP2; V-type proton ATPase catalytic subunit A; VA68; Vma1; V-ATPase subuni
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ATP6V1A-1000H Recombinant Human ATP6V1A protein, GST-tagged Wheat Germ GST
    Human ATP6V1A-10040H Recombinant Human ATP, His-tagged E.coli His
    Human ATP6V1A-8585HCL Recombinant Human ATP6V1A 293 Cell Lysate HEK293 N/A
    Mouse ATP6V1A-2158M Recombinant Mouse ATP6V1A Protein Mammalian Cell His
    Rhesus Macaque ATP6V1A-466R Recombinant Rhesus monkey ATP6V1A Protein, His-tagged Mammalian Cell His
    Chicken ATP6V1A-6533C Recombinant Chicken ATP6V1A Mammalian Cell His

    ATP6V1A involved in several pathways and played different roles in them. We selected most pathways ATP6V1A participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6V1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Oxidative phosphorylation NDUFB5; LHPP; ATP6V1G1; ATP5IB; ATP5F1; NDUFS4; NDUFAB1A; ATP6V0A2B; ATP4A; NDUFS8B
    Metabolic pathways PNPLA2; NT5C3B; AKR1B8; MTMR1; MGAT5B; HMGCRA; BHMT; GLYCTK; IDO2; POLR2F
    Phagosome C3A.1; THBS4B; THBS2; FCGR1; ITGA5; BMA2; TUBA3A; MBL1; RAB5B; ATP6V1E1
    Synaptic vesicle cycle NAPA; SLC18A1; SNAP25; ATP6V0E2; UNC13C; ATP6V1B1; RAB3A; ATP6V1G2; ATP6V1B2; ATP6V1F
    Collecting duct acid secretion ATP6V1C1; ATP6V1F; ATP6V1B1; ATP6V0E1; ATP6V1E1; ATP6V0E2; ATP6V1C2; ATP4A; ATP6V0A1; ATP6V1E2
    Vibrio cholerae infection ATP6V1C1; ATP6V1B1; ATP6V0B; PRKACG; ATP6V1C2; ERO1L; ACTG1; ATP6V1F; ATP6V1E1; ATP6V1E2
    Epithelial cell signaling in Helicobacter pylori infection JAM3; MAPK13; MAPK12; ATP6V1G1; ATP6V0A1; ATP6V1H; CXCR2; PLCG1; ATP6V0A2; F11R
    Rheumatoid arthritis HLA-DQA1; ATP6V0A4; ATP6V1D; HLA-DRA; CXCL12; CTLA4; TNFRSF11A; TNF; HLA-DMA; IL23

    ATP6V1A has several biochemical functions, for example, ATP binding, proton-transporting ATPase activity, rotational mechanism. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6V1A itself. We selected most functions ATP6V1A had, and list some proteins which have the same functions with ATP6V1A. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding MAP3K4; TLK1A; ATP1A1A.3; HSPE1; ABCC5; ACTR2A; TARS; PAK2A; MYHZ1.1; HARS
    proton-transporting ATPase activity, rotational mechanism ATP6V0CB; ATP6AP1B; ATPV0E2; ATP5E; ATP6V1E2; ATP6V1E1B; ATP6V0A4; ATP6V1AA; ATP5D; TCIRG1

    ATP6V1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6V1A here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6V1A.

    CHMP4B; HLA-B; TK1; ANXA7; CDKN1A; SMN1; b4e1j8_human; b7z6l9_human; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; pi3p; 15-deoxy-delta(12,14; FLOT2; CALM1; e9pbb7_human; Flot1; TM9SF1; MYO1B; DNAJC13

    Peinado, MA; Hernandez, R; et al. Proteomic characterization of nitrated cell targets after hypobaric hypoxia and reoxygenation in rat brain. JOURNAL OF PROTEOMICS 109:309-321(2014).
    Alzamora, R; Al-Bataineh, MM; et al. AMP-activated protein kinase regulates the vacuolar H+-ATPase via direct phosphorylation of the A subunit (ATP6V1A) in the kidney. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 305:F943-F956(2013).

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