ATP6V1A

  • Official Full Name

    ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A

  • Overview

    This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of;eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular;processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient;generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of;three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP;catalytic site. The V0 domain consists of five different subunits: a, c, c, c, and d. Additional isoforms of many of;the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This;encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues. Transcript variants derived;from alternative polyadenylation exist.
  • Synonyms

    ATP6V1A; ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A; ATP6A1, ATP6V1A1, ATPase, H+ transporting, lysosomal (vacuolar proton pump), alpha polypeptide, 70kD, isoform 1 , VPP2; V-type proton ATPase catalytic subunit A; VA68; Vma1; V-ATPase subuni;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ATP6V1A-1000H Recombinant Human ATP6V1A protein, GST-tagged Wheat Germ GST
Human ATP6V1A-10040H Recombinant Human ATP, His-tagged E.coli His 268-617a.a.
Human ATP6V1A-8585HCL Recombinant Human ATP6V1A 293 Cell Lysate HEK293 N/A
Human ATP6V1A-1500HF Recombinant Full Length Human ATP6V1A Protein, GST-tagged In Vitro Cell Free System GST 617 amino acids
Mouse ATP6V1A-2158M Recombinant Mouse ATP6V1A Protein Mammalian Cell His
Mouse ATP6V1A-875M Recombinant Mouse ATP6V1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ATP6V1A-875M-B Recombinant Mouse ATP6V1A Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ATP6V1A-466R Recombinant Rhesus monkey ATP6V1A Protein, His-tagged Mammalian Cell His
Rhesus Macaque ATP6V1A-295R Recombinant Rhesus Macaque ATP6V1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque ATP6V1A-295R-B Recombinant Rhesus Macaque ATP6V1A Protein Pre-coupled Magnetic Beads HEK293
Chicken ATP6V1A-6533C Recombinant Chicken ATP6V1A Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

ATP6V1A involved in several pathways and played different roles in them. We selected most pathways ATP6V1A participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6V1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Oxidative phosphorylationATP6AP1;ATP6V1C1A;ATP5G3B;MT-ATP6;ATP5J;COX15;NDUFA1;ATP6V1G1;ATP4A
Metabolic pathwaysPOLD4;NME2;Atp5g2;GCH1;MGAT3A;PAFAH1B1A;FPGT;CERS5;IPMK
PhagosomeCORO1A;ATP6V0D1;BLA;CLEC7A;MRC1;BMA1;ATP6AP1;TLR2-1;ATP6V0A1B
Synaptic vesicle cycleRAB3A;ATP6V1D;ATP6V1B2;STX1A;STXBP1;ATP6V1E2;CPLX2;ATP6V0D1;UNC13A
Collecting duct acid secretionATP6V0D2;ATP4A;ATP4B;ATP6V1E1;ATP6V1F;CLCNKB;ATP6V0E2;ATP6V1C2;SLC4A1
Vibrio cholerae infectionATP6V1A;PRKCA;ATP6V0D2;SEC61G;ATP6AP1;ATP6V0A1;ERO1L;KDELR2;PRKACG
Epithelial cell signaling in Helicobacter pylori infectionCXCR2;ATP6V1C1;ATP6V1G2;ATP6V0B;MAPK11;CCL5;MAPK8;MAP3K14;MAPK13
Rheumatoid arthritisCXCL12;ATP6V1C1;ATP6AP1;IL-8;ATP6V0A4;ATP6V1H;CCL3L3;H2-AB1;HLA-DMA

ATP6V1A has several biochemical functions, for example, ATP binding, proton-transporting ATPase activity, rotational mechanism. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6V1A itself. We selected most functions ATP6V1A had, and list some proteins which have the same functions with ATP6V1A. You can find most of the proteins on our site.

Function Related Protein
ATP bindingNLRP2;SBK1;STK25A;UBE2O;STK32B;IPMK;DDX21;NLK1;CDC42BPB
proton-transporting ATPase activity, rotational mechanismATP6V0CB;ATP6V0B;ATP5E;ATP6V0A1A;ATP6V0E1;ATP6V1F;ATP6V0E;ATP6V1E2;ATPV0E2

ATP6V1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6V1A here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6V1A.

CHMP4B; HLA-B; TK1; ANXA7; CDKN1A; SMN1; b4e1j8_human; b7z6l9_human; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; pi3p; 15-deoxy-delta(12,14; FLOT2; CALM1; e9pbb7_human; Flot1; TM9SF1; MYO1B; DNAJC13

Research Area

Related articles

Peinado, MA; Hernandez, R; et al. Proteomic characterization of nitrated cell targets after hypobaric hypoxia and reoxygenation in rat brain. JOURNAL OF PROTEOMICS 109:309-321(2014).
Alzamora, R; Al-Bataineh, MM; et al. AMP-activated protein kinase regulates the vacuolar H+-ATPase via direct phosphorylation of the A subunit (ATP6V1A) in the kidney. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 305:F943-F956(2013).
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