ATP7B

  • Official Full Name

    ATPase, Cu++ transporting, beta polypeptide

  • Overview

    This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD).
  • Synonyms

    ATP7B; ATPase, Cu++ transporting, beta polypeptide; ATPase, Cu++ transporting, beta polypeptide (Wilson disease) , WND; copper-transporting ATPase 2; Wilson disease; copper pump 2; Wilson disease-associated protein; ATPase, Cu(2+)- transporting, beta poly;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ATP7B-174H Recombinant Human ATP7B E.coli N/A
Human ATP7B-1014H Recombinant Human ATP7B protein, GST-tagged Wheat Germ GST
Human ATP7B-8572HCL Recombinant Human ATP7B 293 Cell Lysate HEK293 N/A
Human ATP7B-467H Recombinant Human ATP7B Protein, His-tagged E.coli His Thr59~Val426
Human ATP7B-468H Recombinant Human ATP7B Protein, Myc/ddk-tagged HEK293T Myc/DDK
Human ATP7B-3895H Recombinant Human ATP7B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ATP7B-407H-B Recombinant Human ATP7B Protein Pre-coupled Magnetic Beads HEK293
Human ATP7B-407H Recombinant Human ATP7B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ATP7B-33HFL Recombinant Full Length Human ATP7B Protein, C-Flag-tagged Mammalian cells Flag
Human ATP7B-1054H Recombinant Human ATP7B Protein (Thr59-Val426), His tagged E.coli His Thr59-Val426
Mouse ATP7B-2172M Recombinant Mouse ATP7B Protein Mammalian Cell His
Mouse ATP7B-885M Recombinant Mouse ATP7B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Atp7b-275M Recombinant Mouse Atp7b Protein, His-tagged E.coli N-His Gln1369-Ile1462
Mouse Atp7b-676M Recombinant Mouse Atp7b Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse ATP7B-885M-B Recombinant Mouse ATP7B Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ATP7B Related Articles

ATP7B involved in several pathways and played different roles in them. We selected most pathways ATP7B participated on our site, such as Ion channel transport, Ion transport by P-type ATPases, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP7B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ion channel transportATP8B1;TRPC4A;ATP6V1G3;TRPC5A;TTYH1;ATP1A1A.5;CLCN1A;ATP1A1A.3;ATP10A
Ion transport by P-type ATPasesATP1A1A.2;FXYD3;ATP2B1B;FXYD6-FXYD2;ATP2C2;CUTC;FXYD6;CCC2;ATP2C1
Transmembrane transport of small moleculesBEST4;SLC31A1;ANO5B;CLCN6;SLC15A3;SLC29A4;ANKHA;TSC22D3;SLC26A7

ATP7B has several biochemical functions, for example, ATP binding, copper ion binding, copper-exporting ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP7B itself. We selected most functions ATP7B had, and list some proteins which have the same functions with ATP7B. You can find most of the proteins on our site.

Function Related Protein
ATP bindingDDX3X;PI4KB;CCT7;EIF2AK1;OAS1B;CDK10;MAP3K6;UBE2T;CSNK1G2
copper ion bindingTYRP1B;LOXL5B;HAMP;HEPHL1;APOA4;COMMD1;SNAI3;LOXL2A;MOXD2
copper-exporting ATPase activityATP7A;ATP7B
protein bindingDYX1C1;RPL14;ATP6V1E1;RAB11FIP3;TUBB4A;TSSK6;FHOD1;PHAX;UPF3B

ATP7B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP7B here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP7B.

Palm-Espling, ME; Lundin, C; et al. Interaction between the Anticancer Drug Cisplatin and the Copper Chaperone Atox1 in Human Melanoma Cells. PROTEIN AND PEPTIDE LETTERS 21:63-68(2014).
Valtorta, S; Belloli, S; et al. Comparison of F-18-Fluoroazomycin-Arabinofuranoside and Cu-64-Diacetyl-Bis(N4-Methylthiosemicarbazone) in Preclinical Models of Cancer. JOURNAL OF NUCLEAR MEDICINE 54:1106-1112(2013).
  • Q&As
  • Reviews

Q&As (5)

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How does the ATP7B protein contribute to copper transport within cells, and what cellular compartments are involved in this process? 01/14/2022

ATP7B facilitates copper transport from the cytoplasm to the Golgi apparatus, where copper is incorporated into proteins. It also mediates copper export from cells when copper levels are elevated, preventing toxicity.

How does ATP7B interact with other proteins involved in copper metabolism, and what are the implications of disruptions in these interactions? 02/22/2021

ATP7B interacts with various proteins in the copper transport pathway. Disruptions in these interactions can lead to mislocalization of ATP7B and compromise its ability to regulate copper levels properly.

How does ATP7B-mediated copper transport impact the activity of copper-dependent enzymes, and what are the broader implications for cellular function? 09/18/2020

ATP7B ensures the proper supply of copper to enzymes involved in various cellular processes, including energy production and antioxidant defense. Dysregulation can disrupt these processes, affecting cell function.

What is the role of ATP7B in copper excretion at the systemic level, and how does this relate to copper metabolism in the body? 05/30/2019

ATP7B is crucial for copper excretion into bile, a process that contributes to systemic copper balance. Dysfunctional ATP7B results in impaired copper excretion, leading to the accumulation of copper in tissues.

Can you explain the consequences of mutations in the ATP7B gene, particularly in relation to Wilson's disease? 11/05/2018

Mutations in the ATP7B gene lead to impaired copper transport, causing copper accumulation in tissues. This is associated with Wilson's disease, a disorder characterized by copper toxicity, especially in the liver and brain.

Customer Reviews (3)

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Reviews
01/15/2021

    Impressed with the product quality.

    05/09/2020

      The product exceeded expectations.

      09/28/2018

        This product consistently delivers accurate results in our experiments.

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