Recombinant Full Length Human ATP7B Protein, C-Flag-tagged
Cat.No. : | ATP7B-33HFL |
Product Overview : | Recombinant Full Length Human ATP7B Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
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Description : | This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein is a monomer, and functions as a copper-transporting ATPase which exports copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease which is characterized by copper accumulation. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 157.1 kDa |
AA Sequence : | MPEQERQITAREGASRKILSKLSLP TRAWEPAMKKSFAFDNVGYEGGLDG LGPSSQVATSTVRILGMTCQ SCVKSIEDRISNLKGIISMKVSLEQ GSATVKYVPSVVCLQQVCHQIGDMG FEASIAEGKAASWPSRSLPA QEAVVKLRVEGMTCQSCVSSIEGKV RKLQGVVRVKVSLSNQEAVITYQPY LIQPEDLRDHVNDMGFEAAI KSKVAPLSLGPIDIERLQSTNPKRP LSSANQNFNNSETLGHQGSHVVTLQ LRIDGMHCKSCVLNIEENIG QLLGVQSIQVSLENKTAQVKYDPSC TSPVALQRAIEALPPGNFKVSLPDG AEGSGTDHRSSSSHSPGSPP RNQVQGTCSTTLIAIAGMTCASCVH SIEGMISQLEGVQQISVSLAEGTAT VLYNPAVISPEELRAAIEDM GFEASVVSESCSTNPLGNHSAGNSM VQTTDGTPTSLQEVAPHTGRLPANH APDILAKSPQSTRAVAPQKC FLQIKGMTCASCVSNIERNLQKEAG VLSVLVALMAGKAEIKYDPEVIQPL EIAQFIQDLGFEAAVMEDYA GSDGNIELTITGMTCASCVHNIESK LTRTNGITYASVALATSKALVKFDP EIIGPRDIIKIIEEIGFHAS LAQRNPNAHHLDHKMEIKQWKKSFL CSLVFGIPVMALMIYMLIPSNEPHQ SMVLDHNIIPGLSILNLIFF ILCTFVQLLGGWYFYVQAYKSLRHR SANMDVLIVLATSIAYVYSLVILVV AVAEKAERSPVTFFDTPPML FVFIALGRWLEHLAKSKTSEALAKL MSLQATEATVVTLGEDNLIIREEQV PMELVQRGDIVRVVPGGKFP VDGKVLEGNTMADESLITGEAMPVT KKPGSTVIAGSINAHGSVLIKATHV GNDTTLAQIVKLVEEAQMSK APIQQLADRFSGYFVPFIIIMSTLT LVVWIVIGFIDFGVVQKYFPNPNKH ISQTEVIIRFAFQTSITVLC IACPCSLGLATPTAVMVGTGVAAQN GILIKGGKPLEMAHKIKTVMFDKTG TITHGVPRVMRVLLLGDVAT LPLRKVLAVVGTAEASSEHPLGVAV TKYCKEELGTETLGYCTDFQAVPGC GIGCKVSNVEGILAHSERPL SAPASHLNEAGSLPAEKDAAPQTFS VLIGNREWLRRNGLTISSDVSDAMT DHEMKGQTAILVAIDGVLCG MIAIADAVKQEAALAVHTLQSMGVD VVLITGDNRKTARAIATQVGINKVF AEVLPSHKVAKVQELQNKGK KVAMVGDGVNDSPALAQADMGVAIG TGTDVAIEAADVVLIRNDLLDVVAS IHLSKRTVRRIRINLVLALI YNLVGIPIAAGVFMPIGIVLQPWMG SAAMAASSVSVVLSSLQLKCYKKPD LERYEAQAHGHMKPLTASQV SVHIGMDDRWRDSPRATPWDQVSYV SQVSLSSLTSDKPSRHSAAADDDGD KWSLLLNGRDEEQYITRTRPLEQKL ISEEDLAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : | Druggable Genome, Transmembrane |
Gene Name : | ATP7B ATPase copper transporting beta [ Homo sapiens (human) ] |
Official Symbol : | ATP7B |
Synonyms : | WD; PWD; WC1; WND |
Gene ID : | 540 |
mRNA Refseq : | NM_000053.4 |
Protein Refseq : | NP_000044.2 |
MIM : | 606882 |
UniProt ID : | P35670 |
Products Types
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Atp7b-275M | Recombinant Mouse Atp7b Protein, His-tagged | +Inquiry |
ATP7B-407H | Recombinant Human ATP7B Protein, His (Fc)-Avi-tagged | +Inquiry |
ATP7B-885M | Recombinant Mouse ATP7B Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
ATP7B-8572HCL | Recombinant Human ATP7B 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionATP7B facilitates copper transport from the cytoplasm to the Golgi apparatus, where copper is incorporated into proteins. It also mediates copper export from cells when copper levels are elevated, preventing toxicity.
ATP7B interacts with various proteins in the copper transport pathway. Disruptions in these interactions can lead to mislocalization of ATP7B and compromise its ability to regulate copper levels properly.
ATP7B ensures the proper supply of copper to enzymes involved in various cellular processes, including energy production and antioxidant defense. Dysregulation can disrupt these processes, affecting cell function.
ATP7B is crucial for copper excretion into bile, a process that contributes to systemic copper balance. Dysfunctional ATP7B results in impaired copper excretion, leading to the accumulation of copper in tissues.
Mutations in the ATP7B gene lead to impaired copper transport, causing copper accumulation in tissues. This is associated with Wilson's disease, a disorder characterized by copper toxicity, especially in the liver and brain.
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