Recombinant Mouse Atp7b Protein, His-tagged
Cat.No. : | Atp7b-275M |
Product Overview : | Recombinant Mouse Atp7b Protein (Gln1369-Ile1462) with N-His tag was expressed in E. coli. |
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Description : | Enables P-type divalent copper transporter activity. Acts upstream of or within several processes, including cellular transition metal ion homeostasis; lactation; and protein maturation by copper ion transfer. Located in membrane and trans-Golgi network. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study Wilson disease. Human ortholog(s) of this gene implicated in Wilson disease. Orthologous to human ATP7B (ATPase copper transporting beta). |
Source : | E. coli |
Species : | Mouse |
Tag : | His |
Form : | Freeze-dried powder |
Molecular Mass : | Predicted Molecular Mass: 14.3 kDa Accurate Molecular Mass: 14 kDa |
Protein length : | Gln1369-Ile1462 |
Purity : | > 97% |
Applications : | Positive Control; Immunogen; SDS-PAGE; WB. |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months. |
Storage Buffer : | 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300. |
Reconstitution : | Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL. Do not vortex. |
Gene Name : | Atp7b ATPase, Cu++ transporting, beta polypeptide [ Mus musculus (house mouse) ] |
Official Symbol : | Atp7b |
Synonyms : | ATP7B; ATPase, Cu++ transporting, beta polypeptide; copper-transporting ATPase 2; toxic milk; copper pump 2; Wilson protein; wilson disease-associated protein homolog; tx; WND; Atp7a |
Gene ID : | 11979 |
mRNA Refseq : | NM_007511 |
Protein Refseq : | NP_031537 |
UniProt ID : | Q64446 |
Products Types
◆ Recombinant Protein | ||
ATP7B-468H | Recombinant Human ATP7B Protein, Myc/ddk-tagged | +Inquiry |
ATP7B-407H | Recombinant Human ATP7B Protein, His (Fc)-Avi-tagged | +Inquiry |
ATP7B-885M | Recombinant Mouse ATP7B Protein, His (Fc)-Avi-tagged | +Inquiry |
Atp7b-676M | Recombinant Mouse Atp7b Protein, MYC/DDK-tagged | +Inquiry |
ATP7B-467H | Recombinant Human ATP7B Protein, His-tagged | +Inquiry |
◆ Lysates | ||
ATP7B-8572HCL | Recombinant Human ATP7B 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Write a reviewImpressed with the product quality.
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Q&As (5)
Ask a questionATP7B facilitates copper transport from the cytoplasm to the Golgi apparatus, where copper is incorporated into proteins. It also mediates copper export from cells when copper levels are elevated, preventing toxicity.
ATP7B interacts with various proteins in the copper transport pathway. Disruptions in these interactions can lead to mislocalization of ATP7B and compromise its ability to regulate copper levels properly.
ATP7B ensures the proper supply of copper to enzymes involved in various cellular processes, including energy production and antioxidant defense. Dysregulation can disrupt these processes, affecting cell function.
ATP7B is crucial for copper excretion into bile, a process that contributes to systemic copper balance. Dysfunctional ATP7B results in impaired copper excretion, leading to the accumulation of copper in tissues.
Mutations in the ATP7B gene lead to impaired copper transport, causing copper accumulation in tissues. This is associated with Wilson's disease, a disorder characterized by copper toxicity, especially in the liver and brain.
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