Bax

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Bax

Official Full Name BCL2-associated X protein
Background This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.
Synonyms BAX; bcl2-L-4; BCL2L4; Bcl2-L-4; BCL2-associated X protein; Bcl-2-associated X protein; Apoptosis regulator BAX; apoptosis regulator BAX; Bcl-2-like protein 4; bcl-2-like protein 4; OTTHUMP00000218291; OTTHUMP00000218292; OTTHUMP00000218293; OTTHUMP00000218294; OTTHUMP00000218295; OTTHUMP00000218296
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human BAX-094H Recombinant Human BAX Protein, GST-tagged Wheat Germ GST
    Human BAX-095H Recombinant Human BAX Protein, GST-tagged Wheat Germ GST
    Human BAX-26650TH Recombinant Human BAX protein, GST-tagged E.coli GST
    Human BAX-321H Recombinant Human BCL2-Associated X Protein, GST-tagged E.coli GST
    Human BAX-3974H Recombinant Human BAX Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human BAX-458H Recombinant Human BAX Mammalian Cell His
    Human BAX-6975H Recombinant Human BAX, GST-tagged E.coli GST
    Human BAX-6976H Recombinant Human BAX, His-tagged E.coli His
    Human BAX-8493H Recombinant human BAX protein, GST-tagged E.coli GST
    Human BAX-8506HCL Recombinant Human BAX 293 Cell Lysate HEK293 N/A
    Mouse Bax-1381M Recombinant Mouse BCL2-associated X Protein, GST-tagged E.coli GST
    Mouse BAX-2300M Recombinant Mouse BAX Protein Mammalian Cell His
    Mouse Bax-244M Recombinant Mouse BCL2-associated X Protein E.coli N/A
    Mouse Bax-691M Recombinant Mouse Bax Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rhesus Macaque BAX-514R Recombinant Rhesus monkey BAX Protein, His-tagged Mammalian Cell His

    Bax involved in several pathways and played different roles in them. We selected most pathways Bax participated on our site, such as Sphingolipid signaling pathway, p signaling pathway, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with Bax were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Sphingolipid signaling pathway ABCC1; SPTLC3; LASS1; RAC2; GNAI2; MAPK8; S1PR4; HRAS; SPHK1; NRAS
    p signaling pathway SESN1; GADD45BB; TP53I3; IGF1; TP53; SIAH1; SIAH1A; CYCSB; CDK1; CCNG1
    Protein processing in endoplasmic reticulum DNAJC5GA; ATXN3; RPN1; RAD23AB; BAXA; DNAJC10; HSPA1B; CUL1B; CANX; GSBP9
    Apoptosis BNIP3LB; TNFRSF10A; IKBKG; HMGB2; CSF2RB; CAPN1B; ADD1; CASP10; BIRC5A; TP53
    Neurotrophin signaling pathway PLCG1; CAMK4; PIK3R5; NGFRAP1; RAPGEF1; AKT2; MAPK8; RAP1A; MAP2K2; PDPK1
    Non-alcoholic fatty liver disease (NAFLD) GSK3A; XBP1; BID; NDUFA9; NDUFA12; PRKAB1; KCNA3; COX7B; NDUFV2; FAS
    Amyotrophic lateral sclerosis (ALS) TOMM40L; ALS2; DAXX; BCL2L1; BCL2; MAP2K3; BID; GRIN2A; NEFL; TNF
    Huntingtons disease DNAH6; NDUFV1; NRF1; POLR2L; GRIN1; POLR2J3; NDUFA9; POLR2B; POLR2K; TFAM
    Prion diseases NOTCH1; Hc; IL1A; STIP1; IL1B; C7; HSPA5; PRKACB; CCL5; NCAM2
    Tuberculosis HLA-DOA; CD209B; APAF1; CD209; IFNA8; NFYB; IL6; CALML3; Itgam&Itgb2; PPP3CA
    Hepatitis B IFNA7; ATF4; NFKBIA; DDX58; IL-8; EGR2; CREB5; NFATC3; IFNA21; OSTN
    HTLV-I infection HLA-DPA1; PDGFRB; WNT2B; ANAPC7; NFKB1; MAP3K14; TGFB2; BUB3; DVL2; NFATC2
    Pathways in cancer RARB; RBX1; GNG3; SPI1; FOXO1; WNT11; STAT1; GNAI1; LAMB2; ARHGEF12
    Viral carcinogenesis SCRIB; HIST1H4L; HLA-A; RHOA; SP100; RBL1; EP300; TBPL1; HIST1H4B; HPN
    Colorectal cancer RAF1; TGFB1; SMAD4; RALGDS; PIK3R1; PIK3CD; PIK3CG; MAPK9; BIRC5; TGFB2

    Bax has several biochemical functions, for example, BH3 domain binding, channel activity, chaperone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Bax itself. We selected most functions Bax had, and list some proteins which have the same functions with Bax. You can find most of the proteins on our site.

    Function Related Protein
    BH3 domain binding BCL2L1; BCL2; BAX; MCL1
    channel activity PANX2; GJA8; PANX1A; BAX; TRPA1; PANX1B; BAXA; BAXB; STEAP1; P2RX6
    chaperone binding TBCD; PFDN6; HSCB; DNAJB6; AHSA2; PRNP; CALR; BAG2; DNAJB4; TBCC
    heat shock protein binding HSPA6; PPP5C; HSPA8; HDAC2; DLST; DNAJA3B; BCOR; DNAJC7; DNAJC9; FKBP5
    identical protein binding TRIP13; CDC42BPA; ACTB; SERPINB1A; KRTAP10-5; AMELX; CHMP4B; CRYAA; C; OAT
    lipid binding PSAP; LPAR3; ATP5G1; BPIFA3; SEC14L3; FNBP1; STARD13; APOC2; APOH; APODA.2
    protein binding CASR; POLE4; KCNG4; CPNE1; PRKAA1; ETS2; CTLA4; ARPC5; SKI; CD300LD
    protein complex binding DLG4; BAX; YWHAB; FYB; GIT1; KAT2B; RPAIN; NRAS; KAT6B; CRHR1
    protein heterodimerization activity BARD1; HER5; DMRT3; NPM1; CREB3L3; SNX2; KCNK9; BTBD11; CHRNB4; NKX2-5
    protein homodimerization activity GPD1C; ADD1; CAMK2B; ABCB9; PRLR; PPP2R4; CTSE; CD247; RNF40; RAB11FIP4A

    Bax has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Bax here. Most of them are supplied by our site. Hope this information will be useful for your research of Bax.

    Beers, K; Ferguson, J; et al. Comparison of the RAPID-B-(R) flow cytometer and the BAX((R)) system for the detection of non-0157 shiga toxin-producing Escherichia coli (STEC) in beef products. FOOD CONTROL 50:72-75(2015).
    Gurzu, S; Kadar, Z; et al. Gastric cancer in young vs old Romanian patients: immunoprofile with emphasis on maspin and mena protein reactivity. APMIS 123:223-233(2015).

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