Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human BAX Protein, DYKDDDDK-tagged

Cat.No. : BAX-31H
Product Overview : Recombinant protein from the full-length sequence of Homo sapiens BCL2 associated X, apoptosis regulator (BAX), transcript variant alpha (NM_138761), with a DYKDDDDK tag was expressed in human cells.
  • Specification
  • Gene Information
  • Related Products
Description : The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
Source : Human cells
Species : Human
Tag : DYKDDDDK
Molecular Mass : 22.1 kDa
Endotoxin : < 0.1 ng/ μg of protein (< 1 EU/ μg)
Purity : > 90% by SDS-PAGE gel and Coomassie Blue staining
Applications : Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
Storage Buffer : Purified protein formulated in a sterile solution of TBS buffer, pH7.4, without any preservatives
Gene Name : BAX BCL2 associated X, apoptosis regulator [ Homo sapiens (human) ]
Official Symbol : BAX BCL2 associated X, apoptosis regulator [ Homo sapiens (human) ]
Synonyms : BAX; BCL2 associated X, apoptosis regulator; BCL2L4; apoptosis regulator BAX; BCL2 associated X protein; BCL2-associated X protein omega; Baxdelta2G9; Baxdelta2G9omega; Baxdelta2omega; bcl-2-like protein 4; bcl2-L-4
Gene ID : 581
mRNA Refseq : NM_138764
Protein Refseq : NP_620119
MIM : 600040
UniProt ID : Q07812

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (7)

Ask a question
Are genetic mutations in BAX linked to any diseases? 06/12/2022

Some genetic mutations in BAX are associated with cancer.

What therapeutic strategies are being explored involving BAX? 04/04/2022

Strategies include modulating BAX activity for cancer therapy and neurodegenerative diseases.

How does BAX interact with other members of the Bcl-2 protein family? 03/24/2022

BAX can form heterodimers with anti-apoptotic Bcl-2 proteins, or homodimers to promote apoptosis.

What happens when BAX is dysregulated? 04/28/2020

Dysregulation can lead to excessive cell death or contribute to cancer.

What is BAX's role in cellular apoptosis? 02/25/2020

BAX promotes apoptosis by permeabilizing the mitochondrial membrane.

What triggers the activation of BAX? 10/29/2019

Stress signals or cellular damage can trigger BAX activation.

How is BAX regulated within the cell? 10/07/2019

It is regulated by various members of the Bcl-2 family and other signaling pathways.

Customer Reviews (3)

Write a review
Reviews
01/07/2020

    Reliable partner for protein expression and analysis.

    01/23/2019

      Swift and reliable protein purification services.

      01/18/2018

        Consistency in results, a hallmark of their service.

        Ask a Question for All BAX Products

        Required fields are marked with *

        My Review for All BAX Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends