Recombinant Mouse Bmp6 Protein, MYC/DDK-tagged

• Cat.No.: Bmp6-713M
• Product Overview: Purified recombinant protein of full-length mouse bone morphogenetic protein 6 (Bmp6), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Mice lacking this gene exhibit delayed ossification of the sternum, iron overload, and reduced fertility in females.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 56.4 kDa
• Purity: >80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Bmp6 bone morphogenetic protein 6 [ Mus musculus (house mouse) ]
• Official Symbol: Bmp6
• Synonyms: Bmp6; bone morphogenetic protein 6; Vgr1; D13Wsu115e; bone morphogenetic protein 6; VG-1-related protein
• Gene ID: 12161
• mRNA Refseq: NM_007556
• Protein Refseq: NP_031582
• UniProt ID: P20722

Reviews

08/14/2022

The BMP6 protein has proven to be an invaluable tool in protein electron microscopy (EM) structure analysis.

11/02/2020

The BMP6 protein is of exceptional quality, making it an ideal choice to meet my experimental needs.

10/15/2019

This protein demonstrates great performance in WB assays, providing accurate and reliable results that are crucial for protein analysis.

Q&As

Are there any ongoing clinical trials involving BMP6?

Yes, there are several ongoing clinical trials investigating the therapeutic applications of BMP6, including its use in bone regeneration and the treatment of musculoskeletal disorders.

Can BMP6 be used in conjunction with other growth factors?

Yes, BMP6 is often used in combination with other growth factors and scaffolds to enhance its regenerative potential, especially in tissue engineering applications.

Is BMP6 only relevant for bone-related conditions?

No, BMP6's influence extends beyond bone health. It has been implicated in various cellular processes, including iron homeostasis, and its therapeutic potential is being explored in multiple medical fields.

How does BMP6 contribute to the treatment of bone disorders?

BMP6 has therapeutic potential in treating bone disorders, such as non-union fractures and osteoporosis. Its ability to stimulate bone formation makes it a valuable candidate for regenerative medicine.

Can BMP6 be administered systemically or is it site-specific?

BMP6 can be administered both locally and systemically, depending on the therapeutic goals. Local administration is often preferred for targeted effects, such as bone regeneration at a specific site.