| Description : |
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Differential expression of this gene may be associated with progression of breast and prostate cancer. Mutations in this gene may be associated with iron overload in human patients. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
57 kDa |
| AA Sequence : |
MPGLGRRAQWLCWWWGLLCSCCGPP PLRPPLPAAAAAAAGGQLLGDGGSP GRTEQPPPSPQSSSGFLYRRLKTQE KREMQKEILSVLGLPHRPRPLHGLQ QPQPPALRQQEEQQQQQQLPRGEPP PGRLKSAPLFMLDLYNALSADNDED GASEGERQQSWPHEAASSSQRRQPP PGAAHPLNRKSLLAPGSGSGGASPL TSAQDSAFLNDADMVMSFVNLVEYD KEFSPRQRHHKEFKFNLSQIPEGEV VTAAEFRIYKDCVMGSFKNQTFLIS IYQVLQEHQHRDSDLFLLDTRVVWA SEEGWLEFDITATSNLWVVTPQHNM GLQLSVVTRDGVHVHPRAAGLVGRD GPYDKQPFMVAFFKVSEVHVRTTRS ASSRRRQQSRNRSTQSQDVARVSSA SDYNSSELKTACRKHELYVSFQDLG WQDWIIAPKGYAANYCDGECSFPLN AHMNATNHAIVQTLVHLMNPEYVPK PCCAPTKLNAISVLYFDDNSNVILK KYRNMVVRACGCHTRTRPLEQKLIS EEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
