Recombinant Human BMP6 Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : BMP6-5977H
Product Overview : BMP6 MS Standard C13 and N15-labeled recombinant protein (NP_001709) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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Description : This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Differential expression of this gene may be associated with progression of breast and prostate cancer. Mutations in this gene may be associated with iron overload in human patients.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 57 kDa
AA Sequence : MPGLGRRAQWLCWWWGLLCSCCGPP PLRPPLPAAAAAAAGGQLLGDGGSP GRTEQPPPSPQSSSGFLYRRLKTQE KREMQKEILSVLGLPHRPRPLHGLQ QPQPPALRQQEEQQQQQQLPRGEPP PGRLKSAPLFMLDLYNALSADNDED GASEGERQQSWPHEAASSSQRRQPP PGAAHPLNRKSLLAPGSGSGGASPL TSAQDSAFLNDADMVMSFVNLVEYD KEFSPRQRHHKEFKFNLSQIPEGEV VTAAEFRIYKDCVMGSFKNQTFLIS IYQVLQEHQHRDSDLFLLDTRVVWA SEEGWLEFDITATSNLWVVTPQHNM GLQLSVVTRDGVHVHPRAAGLVGRD GPYDKQPFMVAFFKVSEVHVRTTRS ASSRRRQQSRNRSTQSQDVARVSSA SDYNSSELKTACRKHELYVSFQDLG WQDWIIAPKGYAANYCDGECSFPLN AHMNATNHAIVQTLVHLMNPEYVPK PCCAPTKLNAISVLYFDDNSNVILK KYRNMVVRACGCHTRTRPLEQKLIS EEDLAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : BMP6 bone morphogenetic protein 6 [ Homo sapiens (human) ]
Official Symbol : BMP6
Synonyms : BMP6; bone morphogenetic protein 6; vegetal related growth factor (TGFB related), VGR; VGR1; BMP-6; VGR-1; VG-1-R; VG-1-related protein; Vg1-related sequence; vegetal-related (TGFB related) cytokine; vegetal related growth factor (TGFB-related); VGR;
Gene ID : 654
mRNA Refseq : NM_001718
Protein Refseq : NP_001709
MIM : 112266
UniProt ID : P22004

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any ongoing clinical trials involving BMP6? 01/27/2022

Yes, there are several ongoing clinical trials investigating the therapeutic applications of BMP6, including its use in bone regeneration and the treatment of musculoskeletal disorders.

Can BMP6 be used in conjunction with other growth factors? 10/09/2017

Yes, BMP6 is often used in combination with other growth factors and scaffolds to enhance its regenerative potential, especially in tissue engineering applications.

Is BMP6 only relevant for bone-related conditions? 11/01/2016

No, BMP6's influence extends beyond bone health. It has been implicated in various cellular processes, including iron homeostasis, and its therapeutic potential is being explored in multiple medical fields.

How does BMP6 contribute to the treatment of bone disorders? 08/08/2016

BMP6 has therapeutic potential in treating bone disorders, such as non-union fractures and osteoporosis. Its ability to stimulate bone formation makes it a valuable candidate for regenerative medicine.

Can BMP6 be administered systemically or is it site-specific? 01/15/2016

BMP6 can be administered both locally and systemically, depending on the therapeutic goals. Local administration is often preferred for targeted effects, such as bone regeneration at a specific site.

Customer Reviews (3)

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08/14/2022

    The BMP6 protein has proven to be an invaluable tool in protein electron microscopy (EM) structure analysis.

    11/02/2020

      The BMP6 protein is of exceptional quality, making it an ideal choice to meet my experimental needs.

      10/15/2019

        This protein demonstrates great performance in WB assays, providing accurate and reliable results that are crucial for protein analysis.

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