Recombinant Human bone morphogenetic protein 6, His-tagged
Cat.No. : | BMP6-575H |
Product Overview : | BMP6, 375-513aa, Human, His tag, E.coli |
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Description : | The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, BMP6 has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity. Recombinant human BMP6 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
Source : | E.coli |
Species : | Human |
Tag : | His-tag |
Form : | Liquid. In 10mM Sodium citrate buffer (pH 3.5) containing 10% glycerol. |
Molecular Mass : | 18 kDa (164aa) confirmed by MALDI-TOF |
AA Sequence : | MGSSHHHHHH SSGLVPRGSH MGSHMSASSR RRQQSRNRST QSQDVARVSS ASDYNSSELK TACRKHELYV SFQDLGWQDW IIAPKGYAAN YCDGECSFPL NAHMNATNHA IVQTLVHLMN PEYVPKPCCA PTKLNAISVL YFDDNSNVIL KKYRNMVVRA CGCH |
Purity : | >85% by SDS - PAGE |
Storage : | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles. |
Concentration : | 0.25 mg/ml (determined by Bradford assay) |
Protein length : | 375-513 |
Gene Name : | BMP6 bone morphogenetic protein 6 [ Homo sapiens ] |
Official Symbol : | BMP6 |
Synonyms : | BMP6; bone morphogenetic protein 6; vegetal related growth factor (TGFB related) , VGR; VGR1; BMP-6; VGR-1; VG-1-R; VG-1-related protein; Vg1-related sequence; vegetal-related (TGFB related) cytokine; vegetal related growth factor (TGFB-related); VGR; |
Gene ID : | 654 |
mRNA Refseq : | NM_001718 |
Protein Refseq : | NP_001709 |
MIM : | 112266 |
UniProt ID : | P22004 |
Chromosome Location : | 6p24-p23 |
Pathway : | BMP receptor signaling, organism-specific biosystem; Endochondral Ossification, organism-specific biosystem; Hedgehog signaling pathway, organism-specific biosystem; Hedgehog signaling pathway, conserved biosystem; Id Signaling Pathway, organism-specific biosystem; TGF-beta signaling pathway, organism-specific biosystem; TGF-beta signaling pathway, conserved biosystem; |
Function : | BMP receptor binding; cytokine activity; growth factor activity; protein heterodimerization activity; |
Products Types
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BMP6-281H | Active Recombinant Human BMP6 Protein (Val397-His513), C-His tagged, Animal-free, Carrier-free | +Inquiry |
BMP6-656R | Recombinant Rat BMP6 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
BMP6-8430HCL | Recombinant Human BMP6 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewThe BMP6 protein has proven to be an invaluable tool in protein electron microscopy (EM) structure analysis.
The BMP6 protein is of exceptional quality, making it an ideal choice to meet my experimental needs.
This protein demonstrates great performance in WB assays, providing accurate and reliable results that are crucial for protein analysis.
Q&As (5)
Ask a questionYes, there are several ongoing clinical trials investigating the therapeutic applications of BMP6, including its use in bone regeneration and the treatment of musculoskeletal disorders.
Yes, BMP6 is often used in combination with other growth factors and scaffolds to enhance its regenerative potential, especially in tissue engineering applications.
No, BMP6's influence extends beyond bone health. It has been implicated in various cellular processes, including iron homeostasis, and its therapeutic potential is being explored in multiple medical fields.
BMP6 has therapeutic potential in treating bone disorders, such as non-union fractures and osteoporosis. Its ability to stimulate bone formation makes it a valuable candidate for regenerative medicine.
BMP6 can be administered both locally and systemically, depending on the therapeutic goals. Local administration is often preferred for targeted effects, such as bone regeneration at a specific site.
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