Active Recombinant Human BMP6

Cat.No. : BMP6-68H
Product Overview : Recombinant human bone morphogenetic protein 6 (Gln382-His513) was expressed in NSO Cells.
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Cat. No. : BMP6-68H
Description : Bone Morphogenetic Protein 6 (BMP-6), also known as Vgr-1, is one of at least 15 structurally and functionally related BMPs which are members of the transforming growth factor β (TGF-β) superfamily. Human BMP-6 is synthesized as a 513 amino acid (aa) precursor protein that is cleaved at the dibasic cleavage site (RxxR) to release the 18 kDa C-terminal mature protein. Biologically active BMP -6 consists of a disulfide-linked homodimer of the mature proteins. Mature human BMP-6 shares 96% and 98% aa sequence identity with mouse and rat BMP-6, respectively. Cellular responses to BMP-6 are mediated by hetero-oligomeric complexes of type I (Activin RIA/ALK -2 and BMPR-IA/ALK-3) and type II (Activin RIIA and BMPR-II) serine/threonine kinase receptors. Glycosylation of BMP-6 is required for its interaction with Activin RIA. BMP6 induces the expression of Noggin and is subsequently antagonized by Noggin. BMP-6 induces a wide range of cellular responses. It promotes osteoblast differentiation from mesenchymal stem cells, chondrocyte maturation (9), Ang II-induced aldosterone production in the adrenal cortex, hormone production and responsiveness in ovarian granulosa cells, iNOS and TNF-α production in macrophages, the cell death of B cells, and neurite outgrowth. BMP-6 expression is induced in astrocytes surrounding sites of brain injury where it functions as a neuroprotectant. BMP-6 is up-regulated during prostate cancer progression and promotes tumor cell metastasis to bone. Through interactions with the BMP coreceptor RGM-C/Hemojuvelin, BMP-6 plays an important role in iron homeostasis by promoting Hepcidin expression and preventing serum iron overload.
Source : Mammalian cells
Sequence : Gln382-His513
SDS-PAGE : 18 kDa, reducing conditions
Activity : Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 for this effect is typically 0.02-0.15 μg/mL.
Endotoxin Level : <1.0 EU per 1 μg of the protein by the LAL method.
Purity : >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Formulation : Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein. See Certificate of Analysis for details.
Reconstitution : Reconstitute at 100 μg/mL in sterile 4 mMHCl containing at least 0.1% human or bovine serum albumin.
Shipping : The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability &Storage : Use a manual defrost freezer and avoid repeated freeze/thaw cycles. 12 months from date of receipt, 20 to 70°C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, 20 to 70 °C under sterile conditions after reconstitution.
Gene Name : BMP6 bone morphogenetic protein 6 [ Homo sapiens ]
Official Symbol : BMP6
Synonyms : BMP6; bone morphogenetic protein 6; VGR; VG; vegetal related growth factor (TGFB-related); Bone morphogenetic protein 6; VG-1-related protein; VG-1-R; VGR-1
Gene ID : 654
mRNA Refseq : NM_001718
Protein Refseq : NP_001709
MIM : 112266
UniProt ID : P22004
Chromosome Location : 6p24-p23
Pathway : Cytokine-cytokine receptor interaction; Hedgehog signaling pathway; TGF-beta signaling pathway.
Function : cytokine activity; growth factor activity; protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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Reviews
08/14/2022

    The BMP6 protein has proven to be an invaluable tool in protein electron microscopy (EM) structure analysis.

    11/02/2020

      The BMP6 protein is of exceptional quality, making it an ideal choice to meet my experimental needs.

      10/15/2019

        This protein demonstrates great performance in WB assays, providing accurate and reliable results that are crucial for protein analysis.

        Q&As (5)

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        Are there any ongoing clinical trials involving BMP6? 01/27/2022

        Yes, there are several ongoing clinical trials investigating the therapeutic applications of BMP6, including its use in bone regeneration and the treatment of musculoskeletal disorders.

        Can BMP6 be used in conjunction with other growth factors? 10/09/2017

        Yes, BMP6 is often used in combination with other growth factors and scaffolds to enhance its regenerative potential, especially in tissue engineering applications.

        Is BMP6 only relevant for bone-related conditions? 11/01/2016

        No, BMP6's influence extends beyond bone health. It has been implicated in various cellular processes, including iron homeostasis, and its therapeutic potential is being explored in multiple medical fields.

        How does BMP6 contribute to the treatment of bone disorders? 08/08/2016

        BMP6 has therapeutic potential in treating bone disorders, such as non-union fractures and osteoporosis. Its ability to stimulate bone formation makes it a valuable candidate for regenerative medicine.

        Can BMP6 be administered systemically or is it site-specific? 01/15/2016

        BMP6 can be administered both locally and systemically, depending on the therapeutic goals. Local administration is often preferred for targeted effects, such as bone regeneration at a specific site.

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