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CA2

  • Official Full Name

    Carbonic anhydrase II

  • Overview

    Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.
  • Synonyms

    CA 2; CA II; CA-II; CA2; CAC; CAH2_HUMAN; CAII; Car 2; Carbonate dehydratase II; Carbonic anhydrase 2; Carbonic anhydrase B; Carbonic anhydrase C; Carbonic anhydrase II; Carbonic dehydratase; EC 4.2.1.1; IUB: 4.2.1.1; CA, HUMAN LIVER; CA1, BOVINE ERYTHROCYTES; CARBONATE DEHYDRATASE; CARBONATE HYDRO-LYASE; CARBONIC ANHYDRASE; PANCREAS, BOVINE; carbonic anhydrase from bovine erythro-cytes; Dehydratase, carbonate; TDX-02; Car-2; Ltw-5; Lvtw-5; AI131712; Car2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Native Proteins
  • Capsicum annuum (Bell pepper)
  • Chicken
  • Dog
  • Human
  • Mouse
  • Rabbit
  • Rat
  • Rhesus Macaque
  • Rhesus monkey
  • Sheep
  • Zebrafish
  • Dog
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Mouse
  • Rabbit
  • Rat
  • Rhesus monkey
  • Sheep
  • Wheat Germ
  • C
  • Myc
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • SUMO
  • MYC
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CA2-219H Active Recombinant Human CA2 E.coli N/A
Human CA2-0237H Active Recombinant Human CA2 Protein E.coli N/A
Human CA2-1114H Active Recombinant Human CA2 protein, His-tagged E.coli His Met 1-Lys 260
Human CA2-144H Recombinant Human Carbonic Anhydrase II E.coli N/A
Human CA2-27265TH Recombinant Human CA2 E.coli N/A
Human CA2-0238H Recombinant Human CA2 Protein, GST-Tagged Wheat Germ GST
Human CA2-220H Recombinant Human CA2, C13&N15-labeled HEK293 N/A
Human CA2-10619H Recombinant Human CA2, GST-tagged E.coli GST 1-260a.a.
Human CA2-864H Recombinant Human CA2, His tagged E.coli His
Human CA2-7915HCL Recombinant Human CA2 293 Cell Lysate HEK293 N/A
Human CA2-479H-B Recombinant Human CA2 Protein Pre-coupled Magnetic Beads HEK293
Human CA2-114H Recombinant Human CA2 Protein, His-tagged HEK293 His 260
Human CA2-201H Recombinant Human CA2 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human CA2-30H Native Human Carbonic Anhydrase II (CA2) Protein Human N/A
Human CA2-2617H Recombinant Human CA2 protein, His-SUMO-tagged E.coli His-SUMO 2-260aa
Human CA2-2583H Active Recombinant Human CA2 protein E.coli N/A Ser2-Lys260
Human CA2-2060HFL Recombinant Full Length Human CA2 Protein, C-Flag-tagged Mammalian cells Flag
Human CA2-479H Recombinant Human CA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CA2-2734HF Recombinant Full Length Human CA2 Protein, GST-tagged In Vitro Cell Free System GST 260 amino acids
Human CA2-0615H Recombinant Human CA2 Protein (Met1-Lys260), N-His-tagged E.coli N-His Met1-Lys260
Human CA2-354H Recombinant Human CA2 protein, His-tagged HEK293 His 259
Mouse Car2-886M Active Recombinant Mouse Car2 Protein, His-tagged E.coli His
Mouse CAR2-2718M Recombinant Mouse CAR2 Protein Mammalian Cell His
Mouse Car2-1191M Recombinant Mouse Carbonic Anhydrase 2, His-tagged Mouse His
Mouse CA2-1158M-B Recombinant Mouse CA2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Car2-765M Recombinant Mouse Car2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse CA2-31M Native Mouse Carbonic Anhydrase II (CA2) Protein Mouse N/A
Mouse CA2-1158M Recombinant Mouse CA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Car2-7677R Recombinant Rat Car2 protein, His-tagged E.coli His Met1~Lys260 (Accession # P27139)
Rat CA2-1057R Recombinant Rat CA2 Protein Mammalian Cell His
Rat CA2-716R-B Recombinant Rat CA2 Protein Pre-coupled Magnetic Beads HEK293
Rat CA2-33R Native Rat Carbonic Anhydrase II (CA2) Protein Rat N/A
Rat CA2-716R Recombinant Rat CA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus monkey CA2-7678R Recombinant Rhesus monkey CA2 protein, His-tagged E.coli His Met1~Lys260 (Accession # H9FZI2)
Rhesus monkey CA2-35R Native Rhesus monkey Carbonic Anhydrase II (CA2) Protein Rhesus monkey N/A
Rabbit CA2-34R Native Rabbit Carbonic Anhydrase II (CA2) Protein Rabbit N/A
Dog CA2-29D Native Dog Carbonic Anhydrase II (CA2) Protein Dog N/A
Capsicum annuum (Bell pepper) RFL11115CF Recombinant Full Length Capsicum Annuum Beta-Carotene Hydroxylase 2, Chloroplastic(Ca2) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (100-316)
Rhesus Macaque CA2-597R Recombinant Rhesus monkey CA2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CA2-425R Recombinant Rhesus Macaque CA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CA2-425R-B Recombinant Rhesus Macaque CA2 Protein Pre-coupled Magnetic Beads HEK293
Sheep CA2-32S Native Sheep Carbonic Anhydrase II (CA2) Protein Sheep N/A
Zebrafish CA2-9899Z Recombinant Zebrafish CA2 Mammalian Cell His
Chicken CA2-7676C Recombinant Chicken CA2 protein, His-tagged E.coli His Met1~Gln260 (Accession # P07630)
Chicken CA2-6869C Recombinant Chicken CA2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CA2 involved in several pathways and played different roles in them. We selected most pathways CA2 participated on our site, such as Nitrogen metabolism, Proximal tubule bicarbonate reclamation, Collecting duct acid secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with CA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Nitrogen metabolismCA5B;CAR7;CPS1;Car14;CA4;GLUD1B;CAR5A;CA12;CA5
Proximal tubule bicarbonate reclamationAQP1;SLC38A3;PCK1;ATP1A1;CA2;SLC9A3;GLS2;Car2;ATP1A4
Collecting duct acid secretionATP6V1F;Car2;ATP4B;ATP6V0E;ATP6V0C;ATP6V1G2;ATP6V0E1;ATP6V0D2;ATP6V1B1
Gastric acid secretionSST;CAMK2A;MYLK3;ACTB;PLCB1;ATP4B;MYLK4;KCNK2;GNAQ
Pancreatic secretionATP1B3;CPA1;CELA2B;AMY2B;ATP2A3;CPB1;FXYD2;PLCB3;PLA2G10
Bile secretionSLC2A1;SLC10A1;CYP3A4;ATP1B4;ABCG8;Car2;CYP7A1;GNAS;ABCB4

CA2 has several biochemical functions, for example, arylesterase activity, carbonate dehydratase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CA2 itself. We selected most functions CA2 had, and list some proteins which have the same functions with CA2. You can find most of the proteins on our site.

Function Related Protein
arylesterase activityPON2;APMAP;CA2;CA1;PON3;CAR1;Car2;C20orf3;PON1
carbonate dehydratase activityCA2;Car2;CA14;CAR1;Car4;CA9;CA5B;CA15C;CAR7
protein bindingTNFSF13B;C10orf18;GPS1;KLC1;FOXRED2;LTF;IGF2;NRIP1;NAGK
zinc ion bindingRNF138;NUP153;BIRC2;PAPLNB;ZDHHC11;RNF2;MORC1;ZFP330;GRIN2B

CA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CA2.

Cdk1; PCNA; USP42; ANKZF1; PTCHD2

Research Area

Related articles

Kale, SL; Arora, N; et al. Per a 10 activates human derived epithelial cell line in a protease dependent manner via PAR-2. IMMUNOBIOLOGY 220:525-532(2015).
Zhang, Y; Li, H; et al. Melatonin-mediated inhibition of Purkinje neuron P-type Ca2+ channels in vitro induces neuronal hyperexcitability through the phosphatidylinositol 3-kinase-dependent protein kinase C delta pathway. JOURNAL OF PINEAL RESEARCH 58:321-334(2015).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
Is CA2 involved in any particular pathological conditions? 07/05/2022

CA2 deficiency is a rare autosomal recessive disorder with metabolic acidosis and osteopetrosis.

What are the known inhibitors of CA2 and their clinical implications? 02/23/2022

Acetazolamide is a known inhibitor, used clinically for glaucoma and altitude sickness.

How do mutations in the CA2 gene influence enzyme activity or stability? 06/13/2021

Some mutations can lead to CA2 deficiency, affecting acid-base balance and leading to metabolic acidosis.

How does CA2's enzymatic activity compare to other carbonic anhydrase isoforms? 07/28/2019

CA2 is one of the most efficient and fastest enzymes, displaying higher activity than many other isoforms.

What role does CA2 play in the physiological regulation of pH? 07/23/2019

CA2 accelerates the reversible conversion of CO2 and water to bicarbonate and protons, aiding in pH regulation.

Are there specific cellular pathways where CA2 plays a significant role? 11/14/2018

CA2 plays a crucial role in CO2 transport and acid-base balance in various tissues.

How is CA2 expression distributed across different human tissues? 07/04/2018

CA2 is ubiquitously expressed but is particularly abundant in red blood cells and certain epithelial tissues.

Customer Reviews (3)

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Reviews
05/01/2022

    Efficient sample processing, a time-saving boon for researchers.

    08/30/2021

      Professional expertise, elevates our protein research projects.

      06/08/2021

        Invaluable assistance for intricate protein experiments.

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