CA2
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Official Full Name
Carbonic anhydrase II
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Overview
Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. -
Synonyms
CA 2; CA II; CA-II; CA2; CAC; CAH2_HUMAN; CAII; Car 2; Carbonate dehydratase II; Carbonic anhydrase 2; Carbonic anhydrase B; Carbonic anhydrase C; Carbonic anhydrase II; Carbonic dehydratase; EC 4.2.1.1; IUB: 4.2.1.1; CA, HUMAN LIVER; CA1, BOVINE ERYTHROCYTES; CARBONATE DEHYDRATASE; CARBONATE HYDRO-LYASE; CARBONIC ANHYDRASE; PANCREAS, BOVINE; carbonic anhydrase from bovine erythro-cytes; Dehydratase, carbonate; TDX-02; Car-2; Ltw-5; Lvtw-5; AI131712; Car2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Native Proteins
- Capsicum annuum (Bell pepper)
- Chicken
- Dog
- Human
- Mouse
- Rabbit
- Rat
- Rhesus Macaque
- Rhesus monkey
- Sheep
- Zebrafish
- Dog
- E. coli
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Human
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Mouse
- Rabbit
- Rat
- Rhesus monkey
- Sheep
- Wheat Germ
- Yeast
- Flag
- GST
- His
- Fc
- Avi
- SUMO
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
CA2 involved in several pathways and played different roles in them. We selected most pathways CA2 participated on our site, such as Nitrogen metabolism, Proximal tubule bicarbonate reclamation, Collecting duct acid secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with CA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Nitrogen metabolism | CAR1;CA6;Car9;GLUL;CAR5A;CA1;CA8;CA4;GLUD1A |
| Proximal tubule bicarbonate reclamation | PCK2;GLS2;MDH1;CA4;ATP1A1;PCK1;AQP1;SLC38A3;CA2 |
| Collecting duct acid secretion | ATP6V0E2;ATP6V1B2;ATP6V0D1;ATP6V0A2;ATP6V1B1;ATP6V1G2;ATP6V0D2;ATP6V0E;SLC12A7 |
| Gastric acid secretion | CALM4;CALM3;ATP1A3;ATP1B4;ITPR1;ATP1A1;MYLK;Car2;GNAI1 |
| Pancreatic secretion | CLCA5;PRKCB;ATP1B3;PLA2G2F;GNAQ;ATP1A4;Slc4a2;CPA2;RAP1B |
| Bile secretion | ABCG8;SLC51A;FAM84B;SLCO1B1;SLC22A1;SLC10A2;CA2;AQP1;ATP1A1 |
CA2 has several biochemical functions, for example, arylesterase activity, carbonate dehydratase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CA2 itself. We selected most functions CA2 had, and list some proteins which have the same functions with CA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| arylesterase activity | PON1;APMAP;Car2;C20orf3;PON2;PON3;CA2;CAR1;CA1 |
| carbonate dehydratase activity | CAR13;Car14;CA15B;CA12;Car8;CA5;CAR15;CAR7;CAR3 |
| protein binding | ACBD3;SNRPG;FMNL3;PSIP1;CDKL3;KLHL6;RSPH1;KCNK16;GSTO2 |
| zinc ion binding | ANPEPB;LHX2A;TP53I3;KPNB1;TRIM46B;TRIM105;USP45;PDLIM5;TET1 |
CA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CA2.
Cdk1; PCNA; USP42; ANKZF1; PTCHD2
Research Area
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Q&As (7)
Ask a questionCA2 deficiency is a rare autosomal recessive disorder with metabolic acidosis and osteopetrosis.
Acetazolamide is a known inhibitor, used clinically for glaucoma and altitude sickness.
Some mutations can lead to CA2 deficiency, affecting acid-base balance and leading to metabolic acidosis.
CA2 is one of the most efficient and fastest enzymes, displaying higher activity than many other isoforms.
CA2 accelerates the reversible conversion of CO2 and water to bicarbonate and protons, aiding in pH regulation.
CA2 plays a crucial role in CO2 transport and acid-base balance in various tissues.
CA2 is ubiquitously expressed but is particularly abundant in red blood cells and certain epithelial tissues.
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