CCL11

  • Official Full Name

    chemokine (C-C motif) ligand 11

  • Overview

    Chemokine (C-C motif) ligand 11 (CCL11) is a small cytokine belonging to the CC chemokine family that is also known as eotaxin-1. CCL11 selectively recruits eosinophils by inducing their chemotaxis, and therefore, is implicated in allergic responses. The effects of CCL11 are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for which CCL11 is a ligand include CCR2, CCR3 and CCR5. However, it has been found that eotaxin-1 (CCL11) has high degree selectivity for its receptor, such that they are inactive on neutrophils and monocytes, which do not express CCR3.[5] The gene for human CCL11 (scya11) is encoded on three exons and is located on chromosome 17.
  • Synonyms

    Ccl11; chemokine (C-C motif) ligand 11; Scya11; eotaxin; eotaxin-1; MGC22554; small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin); small inducible cytokine A11; C-C motif chemokine 11; Eosinophil chemotactic protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Cattle
  • Equine
  • Horse
  • Human
  • Mouse
  • Pig
  • Rabbit
  • Rat
  • Rhesus
  • Rhesus Macaque
  • Rhesus Monkey
  • Sheep
  • CHO
  • E.coli
  • HEK293
  • Human
  • Human Cell
  • Human Cells
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • Biotin
  • DYKDDDDK
  • Fc
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • N/A
  • N
  • SUMO
  • Strep II
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CCL11-167H Active Recombinant Human CCL11, HIgG1 Fc-tagged CHO Fc
Human CCL11P-102H Active Human CCL11, Biotin-tagged Biotin
Human CCL11-172H Active Recombinant Human CCL11 Human N/A
Human CCL11-165H Active Recombinant Human CCL11, MIgG2a Fc-tagged CHO Fc
Human CCL11-166H Active Recombinant Human CCL11, HIgG1 Fc-tagged, mutant CHO Fc
Human CCL11-27H Recombinant Human Chemokine (C-C motif) ligand 11,His-tagged E.coli His
Human CCL11-289H Recombinant Human CCL11, StrepII-tagged Human Cell Strep II 24-97, 74 a.a.
Human CCL11-622H Recombinant Human Chemokine (C-C motif) Ligand 11, His-tagged E.coli His 24-97aa
Human CCL11-225H Recombinant Human CCL11 Protein, His-tagged E.coli His
Human CCL11-595H Recombinant Human CCL11 protein, His & GST-tagged E.coli His/GST Gly24~Pro97 (Accession # Q6I9T4)
Human CCL11-0606H Recombinant Human CCL11 Protein, GST-Tagged Wheat Germ GST
Human CCL11-7735HCL Recombinant Human CCL11 293 Cell Lysate HEK293 N/A
Human CCL11-3903H Recombinant Human CCL11 protein, His-tagged E.coli His 25-97 aa
Human CCL11-3564H Recombinant Human CCL11 protein E.coli N/A 74
Human CCL11-213H Recombinant Human CCL11 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human CCL11-2647H Recombinant Human CCL11 protein, GST-tagged E.coli GST 1-97aa
Human CCL11-1430H Recombinant Human CCL11 Protein (Gly24-Pro97), N-GST tagged E.coli N-GST Gly24-Pro97
Human CCL11-6244H Recombinant Human CCL11 Protein (Ile41-Pro97), N-His-SUMO tagged E.coli N-His-SUMO Ile41-Pro97
Human CCL11-2919HF Recombinant Full Length Human CCL11 Protein, GST-tagged In Vitro Cell Free System GST 97 amino acids
Human CCL11-44H Recombinant Human CCL11 Protein E.coli 74 amino acid
Human CCL11-129C Active Recombinant Human CCL11 Protein (74 aa) E.coli 74
Human CCL11-58H Recombinant Human CCL11 Protein, Biotin-tagged E.coli Biotin
Human CCL11-08H Recombinant Human CCL11 Protein E.coli
Human CCL11-1406H Recombinant Human CCL11 Protein (Gly24-Pro97) E.coli Tag Free Gly24-Pro97
Mouse Ccl11-128M Active Recombinant Mouse Ccl11 Protein E.coli
Mouse Ccl11-620M Recombinant Mouse Ccl11 protein E.coli N/A 74
Mouse CCL11-37M Recombinant Mouse Chemokine (C-C Motif) Ligand 11 E.coli N/A
Mouse Ccl11-4329M Recombinant Mouse Ccl11 Protein Yeast N/A 74aa
Mouse Ccl11-1347M Active Recombinant Mouse Ccl11 Protein E.coli His24-Pro97
Mouse Ccl11-1777M Recombinant Mouse Ccl11 protein, His & GST-tagged E.coli His/GST His24~Pro97
Mouse Ccl11-035C Active Recombinant Mouse Ccl11 Protein (74 aa) E.coli 74
Rat Ccl11-636R Recombinant Rat Ccl11 protein E.coli N/A 74
Rat CCL11-1210R Recombinant Rat CCL11 Protein Mammalian Cell His
Rat Ccl11-596R Recombinant Rat Ccl11 protein, His & GST-tagged E.coli His/GST His24~Pro97 (Accession # P97545)
Rat CCL11-868R-B Recombinant Rat CCL11 Protein Pre-coupled Magnetic Beads HEK293
Rat CCL11-868R Recombinant Rat CCL11 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Monkey CCL11-1155R Active Recombinant Rhesus Monkey CCL11 Protein E.coli N/A
Rabbit CCL11-4377R Recombinant Rabbit CCL11 Protein Yeast N/A 73aa
Bovine CCL11-130B Recombinant Bovine Chemokine (C-C motif) Lligand 11 Yeast N/A
Cattle CCL11-593C Recombinant Cattle CCL11 protein, His & T7-tagged E.coli His/T7 Gln24~Ser97
Equine CCL11-138E Recombinant Equine CCL11 Yeast N/A
Horse CCL11-594H Recombinant Horse CCL11 protein, His & GST-tagged E.coli His/GST Gln24~Phe100
Rhesus CCL11-221R Recombinant Rhesus CCL11 protein E.coli N/A 74
Rhesus Macaque CCL11-679R Recombinant Rhesus monkey CCL11 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CCL11-507R-B Recombinant Rhesus Macaque CCL11 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CCL11-507R Recombinant Rhesus Macaque CCL11 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Sheep CCL11-4345S Recombinant Sheep CCL11 Protein Yeast N/A 74aa
Pig CCL11-149S Recombinant Swine CCL11 Yeast N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CCL11 involved in several pathways and played different roles in them. We selected most pathways CCL11 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Asthma, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionCCR8L;FLT3LG;IFNA21;IFNGR1;IL1B;IL15;EDAR;IL6R;CXCL3
Chemokine signaling pathwayCCL22;CXCL1;PIK3R3;Cxcl15;PAK1;CXCL3;ADRBK1;Ccl27a;ROCK1
AsthmaHLA-DRA;H2-AB1;HLA-DOA;HLA-DMA;HLA-DRB4;HLA-DQB1;PRG2;HLA-DRB1;HLA-DQA1

CCL11 has several biochemical functions, for example, CCR chemokine receptor binding, chemokine activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL11 itself. We selected most functions CCL11 had, and list some proteins which have the same functions with CCL11. You can find most of the proteins on our site.

Function Related Protein
CCR chemokine receptor bindingCCL3L1;CCL24;CCL35.1;CCL17;CCL33.3;CCL19A.2;CXCL32B.1;CCL38A.4;CCL19A.1
chemokine activityCCL34B.9;CXCL1;Ccl12;IL8L2;CCL27B;Ccl9;CCL34A.4;CCL3L3;CCL19A.1
protein bindingTNFRSF13B;PRKRIP1;KPNA2;CEACAM21;HMGB2;JAG2;ARHGEF15;ITM2B;SRM

CCL11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL11 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL11.

DPP4; CCR3; NUDT3; TPI1

Gene Family

GPCRs Chemokines Cytokines

Research Area

Related articles

Sugaya, M; et al. Chemokines and Skin Diseases. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS 63:109-115(2015).
Andreasen, A; Petersen, HH; et al. Immune and inflammatory responses in pigs infected with Trichuris suis and Oesophagostomum dentatum. VETERINARY PARASITOLOGY 207:249-258(2015).
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