CCL11
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Official Full Name
chemokine (C-C motif) ligand 11 -
Overview
Chemokine (C-C motif) ligand 11 (CCL11) is a small cytokine belonging to the CC chemokine family that is also known as eotaxin-1. CCL11 selectively recruits eosinophils by inducing their chemotaxis, and therefore, is implicated in allergic responses. The effects of CCL11 are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for which CCL11 is a ligand include CCR2, CCR3 and CCR5. However, it has been found that eotaxin-1 (CCL11) has high degree selectivity for its receptor, such that they are inactive on neutrophils and monocytes, which do not express CCR3.[5] The gene for human CCL11 (scya11) is encoded on three exons and is located on chromosome 17. -
Synonyms
Ccl11;chemokine (C-C motif) ligand 11;Scya11;eotaxin;eotaxin-1;MGC22554;small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin);small inducible cytokine A11;C-C motif chemokine 11;Eosinophil chemotactic protein
Recombinant Proteins
- Equine
- Human
- Mouse
- Sheep
- Rabbit
- Rhesus macaque
- Rat
- Bovine
- Pig
- Cattle
- Horse
- Yeast
- E.coli
- CHO
- Human
- Wheat Germ
- Mammalian Cells
- Human Cells
- HEK293
- In Vitro Cell Free System
- Non
- His
- Fc
- GST
- Strep II
- T7
- Flag
- Avi
- SUMO
Involved Pathway
CCL11 involved in several pathways and played different roles in them. We selected most pathways CCL11 participated on our site, such as Cytokine-cytokine receptor interaction,Chemokine signaling pathway,Asthma, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemokine signaling pathway | WASL,GNAI1,FOXO3,GNAI2,PIK3R1,PF4V1,VAV1,CXCL11,PPBP,GNG5 |
| Cytokine-cytokine receptor interaction | Cxcl15,CXCL2,TNFSF11,TNFSF10,CXCL1,Il6ra,TNFSF15,KIT,IFNG,INHBA |
| Asthma | TNF,EPX,HLA-DOA,IL3,HLA-DRB1,IL13,IL5,H2-AB1,IL10,FCER1A |
Protein Function
CCL11 has several biochemical functions, for example, CCR chemokine receptor binding,chemokine activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL11 itself. We selected most functions CCL11 had, and list some proteins which have the same functions with CCL11. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| CCR chemokine receptor binding | CCL19,CCL1,CX3CL1,CCL34B.1,CCL17,CCL22,CCL38.1,CCL19A.1,XCL2,CCL18 |
| chemokine activity | CXCL8B.3,CCL19,CCL25B,CXCL2,CCL34B.9,CCL44,CCL28,CCL23,Cxcl15,CCL18 |
| protein binding | UTP14A,RGP1,E2F7,WIBG,SLU7,SIGLEC6,KIAA1609,TSPO,GTF2F2,GNB3 |
Interacting Protein
CCL11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL11 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL11.
DPP4;CCR3;NUDT3;TPI1
Resources
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References
- Sugaya, M; et al. Chemokines and Skin Diseases. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS 63:109-115(2015).
- Andreasen, A; Petersen, HH; et al. Immune and inflammatory responses in pigs infected with Trichuris suis and Oesophagostomum dentatum. VETERINARY PARASITOLOGY 207:249-258(2015).
