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Official Full Name cyclin D1
Background The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
Synonyms CCND1; cyclin D1; BCL1; PRAD1; U21B31; D11S287E; B-cell CLL/lymphoma 1; G1/S-specific cyclin D1; cyclin D1 (PRAD1: parathyroid adenomatosis 1); parathyroid adenomatosis 1; BCL-1 oncogene; PRAD1 oncogene
    • Species :
    • Cattle
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • DDK
    • flag
    • GST
    • His
    • MBP
    • T7
    • MYC/DDK
    • Myc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CCND1-21H Recombinant Human CCND1 protein, His-tagged E. coli His
    Human CCND1-483H Recombinant Human CCND1 Protein, His-GST-tagged E. coli His/GST
    Mouse Ccnd1-798M Recombinant Mouse Ccnd1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human CCND1-834H Recombinant Human CCND1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CCND1-0658H Recombinant Human CCND1 Protein, GST-Tagged Wheat Germ GST
    Human CCND1-1444H Recombinant Human Cyclin D1, GST-tagged E.coli GST
    Human CCND1-171H Recombinant Human CCND1 protein, DDK-tagged Insect Cell DDK
    Human CCND1-221H Recombinant Human CCND1 protein, T7/His-tagged E.coli T7/His
    Human CCND1-23H Recombinant Human CCND1 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CCND1-24H Recombinant Human CCND1 protein, Flag-tagged Insect Cell flag
    Human CCND1-27520TH Recombinant Human CCND1, His-tagged E.coli His
    Human CCND1-27756TH Recombinant Human CCND1 E.coli N/A
    Human CCND1-31773TH Recombinant Human Human CDK6, His-tagged His
    Human CCND1-354H Recombinant Human CCND1 protein, His/MBP-tagged E.coli His/MBP
    Human CCND1-355H Recombinant Human CCND1 protein, His/MBP-tagged E.coli His/MBP
    Human CCND1-7713HCL Recombinant Human CCND1 293 Cell Lysate HEK293 N/A
    Human CDK4/CCND1-633H Recombinant Human CDK4/CCND1, His-tagged Sf9 Insect Cell His
    Human IGLC1-14119H Recombinant Human IGLC1, His-tagged E.coli His
    Mouse Ccnd1-2610M Recombinant Mouse Ccnd1 protein, His-tagged E.coli His
    Mouse CCND1-2988M Recombinant Mouse CCND1 Protein Mammalian Cell His
    Rat CCND1-1219R Recombinant Rat CCND1 Protein Mammalian Cell His
    Rat Ccnd1-2611R Recombinant Rat Ccnd1 protein, His-tagged E.coli His
    Rhesus Macaque CCND1-698R Recombinant Rhesus monkey CCND1 Protein, His-tagged Mammalian Cell His
    Chicken CCND1-2609C Recombinant Chicken CCND1 protein, His-tagged E.coli His
    Chicken CCND1-6933C Recombinant Chicken CCND1 Mammalian Cell His
    Zebrafish CCND1-8654Z Recombinant Zebrafish CCND1 Mammalian Cell His
    Cattle CCND1-2608C Recombinant Cattle CCND1 protein, His & T7-tagged E.coli His/T7

    ccnd1 involved in several pathways and played different roles in them. We selected most pathways ccnd1 participated on our site, such as FoxO signaling pathway, Cell cycle, p signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ccnd1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    FoxO signaling pathway PLK2B; GADD45B; KRAS; PIK3CG; FOXG1; GADD45AA; MAP2K1; GRB2; NLK; INS
    p signaling pathway CD82B; CCND1; RRM2B; PPM1DB; BAX; SESN2; IGF1; Casp3; TP53AIP1; SHISA5
    PIK-Akt signaling pathway PPP2R3A; GNG8; IL3RA; PKN2; FGFR1; SGK1; IFNA21; Il2; TNN; MET
    AMPK signaling pathway CAMKK2; PIK3CD; PIK3R5; PPP2CB; STRADA; PPARG; PFKFB2; TBC1D1; EEF2; G6PC
    Wnt signaling pathway WNT1; FZD3B; PORCN; CTBP2A; WNT3; FZD7A; PRKACAA; CAMK2G; DKK4; FZD7B
    Hippo signaling pathway WNT1; CCND3; PPP2R1B; PPP2R2A; FGF1; DLG1; FZD3; FRMD6; YWHAZ; PPP1CB
    Focal adhesion VCL; FN1; FLT1; RHOA; MYL12A; ITGB1A; RAF1B; ARHGAP35; MYL9B; LAMB4
    Jak-STAT signaling pathway FHL1B; IFNPHI3; CRLF2; IL15RA; SOCS7; GRB2; TYK2; IFNA10; IFNAR2; IL7
    Prolactin signaling pathway ELF5; SHC3; GSK3B; MAPK3; MAPK12; MAP2K1; PIK3R1; SIRPA; INS; LHCGR
    Thyroid hormone signaling pathway RCAN1; PIK3R5; ATP1A2; GATA4; MED4; ATP2A2; ATP1B2; STAT1; MAP2K1; BAD
    Oxytocin signaling pathway NFATC3; OXT; NOS3; CALM1; CAMK1; MAP2K5; PLCB3; PRKAG2; PRKAB1; PPP1CC
    Hepatitis B STAT2; PIK3R3; BAD; TGFB1; VDAC3; IFNA12; OSTN; RB1; NFATC2; MAVS
    Measles PIK3R5; IFNGR1; IFNA1; IFNA14; CD3D; IFNA17; PRKCQ; TLR9; CD209B; IFNA5
    Pathways in cancer Fzd4; FZD6; PTGER1; MSH3; FZD10; FGF18; FAS; LPAR6; RXRA; MAPK9
    Viral carcinogenesis PIK3CA; HIST1H2BJ; HLA-E; ACTN4; CREB5; ATP6V0D1; YWHAB; HIST1H4A; MDM2; HIST1H2BM
    Proteoglycans in cancer ROCK2; PLCG2; IL12B; MSN; EZR; ANK1; RRAS2; KRAS; TRP53; PIK3R3
    MicroRNAs in cancer PDGFB; PDCD4; ITGB3; MMP16; TP63; TTC6; SOCS1; SERPINB5; CCNE1; ERBB3
    Colorectal cancer MAPK10; RHOA; PIK3R5; TP53; MAP2K1; GSK3B; ARAF; KRAS; RAF1; BCL2
    Pancreatic cancer RELA; AKT2; RAF1; RAC1; TGFBR1; ARAF; MAPK3; PIK3R2; IKBKB; SMAD3
    Endometrial cancer TP53; KRAS; PIK3R2; GRB2; PDPK1; ARAF; MAP2K2; GSK3B; PIK3R1; AKT1
    Prostate cancer HSP90AB1; IKBKG; NFKBIA; PIK3CG; MTOR; HSP90AA1; SMARCC2; Pdgfa&Pdgfb; SMARCD1; PIK3R1
    Thyroid cancer CCND1; RXRA; CDH1; NRAS; NCOA4; MAPK3; MAPK1; KRAS; RXRB; MAP2K2
    Melanoma PDGFD; FGF19; RB1; RAF1; FGF4; PIK3R2; MET; MITF; TP53; HRAS
    Bladder cancer MAPK3; MYC; E2F1; TYMP; ARAF; RB1; MAP2K2; HBEGF; IL-8; RPS6KA5
    Chronic myeloid leukemia BCR; SMAD4; GAB2; TGFB2; TGFBR2; PIK3R3; HDAC2; CCND1; PIK3CG; CRK
    Acute myeloid leukemia AKT1; NFKB1; MYC; PIK3CD; PIK3R3; CCND1; SOS1; PIM2; RARA; NRAS
    Small cell lung cancer CASP9; FHIT; LAMB4; LAMA2; LAMC2; CKS2; LAMA4; NOS2; AKT2; CYCS
    Non-small cell lung cancer MAPK1; RXRB; HRAS; PRKCG; ALK; RXRG; PRKCA; STK4; CCND1; FHIT
    Viral myocarditis PRF1; HLA-DRA; HLA-DRB4; HLA-DQA2; ICAM1; CASP9; HLA-DPA1; CXADR; HLA-A; H2-AB1

    ccnd1 has several biochemical functions, for example, cyclin-dependent protein serine/threonine kinase regulator activity, enzyme binding, histone deacetylase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ccnd1 itself. We selected most functions ccnd1 had, and list some proteins which have the same functions with ccnd1. You can find most of the proteins on our site.

    Function Related Protein
    cyclin-dependent protein serine/threonine kinase regulator activity CCNL1A; CKS2; CCNK; CCNT1; PSTPIP2; FAM58A; CCNC; CCNT2A; CKS1B; CCNL1B
    enzyme binding CYP2C19; UGT1A4; GSTM1; RXRA; FAM84B; NFKBIA; NR5A1; UGT1A7; HNRNPUL1; TRP53
    histone deacetylase binding CEBPA; SKOR2; SUDS3; YWHAB; PRDM1; MAGEA2; GLI3; HIC1; WDTC1; PKN2
    proline-rich region binding BAIAP2L1; CCND1; PRPF40A; WBP4; FAM59A; TCERG1; ITSN1; CSK; YAP1; PFN1
    protein binding IK; SPINK2; CCDC94; WDR61; FBP2; SMAD3; GTF2H1; TAF2; RNF40; MZB1
    protein complex binding RANBP2; MTAP1B; KHDRBS1; MYSM1; CDK5RAP2; INS2; FLCN; MYO7A; TUBB; TAB1
    protein kinase activity RIPK1L; NRBP1; MAP2K1; RIPK3; PRKCDA; LIMK1A; RIPK4; TEX14; NPR1A; CSNK1A1
    protein kinase binding KIF13B; CCNT2B; TPX2; PTEN; CDC25C; MAP2K3; CCND3; ACVRL1; CRY1; CCNL1A
    transcription corepressor activity KLF12; HIRA; HIPK2; TFCP2L1; NFIL3; ZNF136; SP100; TBL1XR1; PEX14; BHLHE40
    transcription factor binding RBFOX2; INSIG2; TP73; ATF7; HMGA1-RS1; HMGB1; PSMC5; STK36; CTBP1; THRA

    ccnd1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ccnd1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ccnd1.

    CDK4; CDKN1A

    Tajiri, R; Ooi, A; et al. Intratumoral heterogeneous amplification of ERBB2 and subclonal genetic diversity in gastric cancers revealed by multiple ligation-dependent probe amplification and fluorescence in situ hybridization. HUMAN PATHOLOGY 45:725-734(2014).
    Rao, C; Lin, SL; et al. High Expression of IGFBP7 in Fibroblasts Induced by Colorectal Cancer Cells Is Co-Regulated by TGF-beta and Wnt Signaling in a Smad2/3-Dvl2/3-Dependent Manner. PLOS ONE 9:-(2014).

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