CCND1

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CCND1

Official Full Name cyclin D1
Background The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
Synonyms CCND1; cyclin D1; BCL1; PRAD1; U21B31; D11S287E; B-cell CLL/lymphoma 1; G1/S-specific cyclin D1; cyclin D1 (PRAD1: parathyroid adenomatosis 1); parathyroid adenomatosis 1; BCL-1 oncogene; PRAD1 oncogene
    • Species :
    • Cattle
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • DDK
    • flag
    • GST
    • His
    • MBP
    • T7
    • MYC/DDK
    • Myc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CCND1-0658H Recombinant Human CCND1 Protein, GST-Tagged Wheat Germ GST
    Human CCND1-1444H Recombinant Human Cyclin D1, GST-tagged E.coli GST
    Human CCND1-171H Recombinant Human CCND1 protein, DDK-tagged Insect Cell DDK
    Human CCND1-21H Recombinant Human CCND1 protein, His-tagged E. coli His
    Human CCND1-221H Recombinant Human CCND1 protein, T7/His-tagged E.coli T7/His
    Human CCND1-23H Recombinant Human CCND1 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CCND1-24H Recombinant Human CCND1 protein, Flag-tagged Insect Cell flag
    Human CCND1-27520TH Recombinant Human CCND1, His-tagged E.coli His
    Human CCND1-27756TH Recombinant Human CCND1 E.coli N/A
    Human CCND1-31773TH Recombinant Human Human CDK6, His-tagged His
    Human CCND1-354H Recombinant Human CCND1 protein, His/MBP-tagged E.coli His/MBP
    Human CCND1-355H Recombinant Human CCND1 protein, His/MBP-tagged E.coli His/MBP
    Human CCND1-483H Recombinant Human CCND1 Protein, His-GST-tagged E. coli His/GST
    Human CCND1-7713HCL Recombinant Human CCND1 293 Cell Lysate HEK293 N/A
    Human CCND1-834H Recombinant Human CCND1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CDK4/CCND1-633H Recombinant Human CDK4/CCND1, His-tagged Sf9 Insect Cell His
    Human IGLC1-14119H Recombinant Human IGLC1, His-tagged E.coli His
    Mouse Ccnd1-2610M Recombinant Mouse Ccnd1 protein, His-tagged E.coli His
    Mouse CCND1-2988M Recombinant Mouse CCND1 Protein Mammalian Cell His
    Mouse Ccnd1-798M Recombinant Mouse Ccnd1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rat CCND1-1219R Recombinant Rat CCND1 Protein Mammalian Cell His
    Rat Ccnd1-2611R Recombinant Rat Ccnd1 protein, His-tagged E.coli His
    Rhesus Macaque CCND1-698R Recombinant Rhesus monkey CCND1 Protein, His-tagged Mammalian Cell His
    Chicken CCND1-2609C Recombinant Chicken CCND1 protein, His-tagged E.coli His
    Chicken CCND1-6933C Recombinant Chicken CCND1 Mammalian Cell His
    Zebrafish CCND1-8654Z Recombinant Zebrafish CCND1 Mammalian Cell His
    Cattle CCND1-2608C Recombinant Cattle CCND1 protein, His & T7-tagged E.coli His/T7

    CCND1 involved in several pathways and played different roles in them. We selected most pathways CCND1 participated on our site, such as FoxO signaling pathway, Cell cycle, p signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCND1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    FoxO signaling pathway S1PR4; PRMT1; HOMER1; PLK2; USP7; G6PC2; ATM; MAP2K2A; TNFSF10; IRS1
    Cell cycle H3F3D; CENPA; DCTN3; HJURP; PTTG1; RBBP7; MYBL2; SPO11; ANAPC2; CLSPN
    p signaling pathway CCND2; TSC2; LRDD; SESN2; IGF1; CASP3A; SIAH2L; CASP8; CCNE1; RRM2
    PIK-Akt signaling pathway GNG7; PHLPP2; PPP2R1A; ITGA10; THBS1; PRKAA1; TLR4; PPP2R5D; GNG12; AKT2
    AMPK signaling pathway RAB10; CAB39L; PPP2CA; TSC1; G6PC3; IGF1; PPP2R5D; PFKM; ADIPOR2; INS
    Wnt signaling pathway WNT8A; DAAM2; WNT2; TBL1XR1; WNT3; NFATC2; MAPK8B; PRKACG; NKD2; RAC1B
    Hippo signaling pathway DLG3; BMP8A; WNT6; WNT16; GDF5; YAP1; WNT7B; SMAD2; WWTR1; FZD7
    Focal adhesion CAV2; AKT1; TNR; PDGFC; PAK6B; CDC42; LAMB1A; PIK3R3A; MAPK6; PTK2AB
    Jak-STAT signaling pathway SOCS4; SOCS6; GRB2B; Ifnlr1; JAK2A; PIAS4B; AKT2L; FHL1A; STAT1B; PRLRA
    Prolactin signaling pathway SOCS7; SOCS6; RELA; SOCS2; PRLR; ELF5; NFKB1; CSH; SOCS5; PRL
    Thyroid hormone signaling pathway DIO3; NOTCH1; MAPK3; ATP1B2; NOTCH3; MED30; MED17; KAT2B; TSC2; PLCD1
    Oxytocin signaling pathway PPP3CC; PRKAG1; PLCB3; RYR3; CACNG1; PRKCB; MYLK3; CALM1; Adcy4; PIK3R5
    Hepatitis B IFNAR1; CASP9; STAT5A; FADD; IFIH1; STAT6; HBXIP; MYD88; CREB3L2; CASP10
    Measles MAVS; IFNB1; TBK1; IFNA14; CCNE1; IFNA13; TACR1; DDX58; AKT1; IFNA4
    HTLV-I infection HLA-DPB1; IL2RG; CDC26; HLA-DOA; NFATC3; MSX1; PRKACB; SLC2A1; RRAS; APC
    Pathways in cancer PDGFA; FZD1; LAMB1; GNG12; FGF17; F2R; MMP1A; LPAR5; ROCK1; RXRG
    Viral carcinogenesis HDAC2; TRAF2; BAD; VAC14; MAPK1; HIST1H4L; STAT3; PIK3CB; GTF2E2; CREB5
    Proteoglycans in cancer FGFR1; TP53; ROCK1; MAP2K1; PPP1CB; SOS1; GPC1; AKT1; RRAS2; RPS6
    MicroRNAs in cancer MAPK1; MCL1; DNMT1; KRAS; DNMT3B; RAF1; IKBKB; IRS1; ERBB2; APC2
    Colorectal cancer MAPK10; MLH1; SMAD2; CYCS; LEF1; PIK3CG; Casp3; TGFB2; SMAD3; MAPK9
    Pancreatic cancer ARAF; TGFBR2; RALBP1; BRCA2; MAP2K1; TGFB1; MAPK8; TP53; RAF1; PIK3CB
    Endometrial cancer HRAS; KRAS; BAD; TCF7; RAF1; ERBB2; BRAF; ILK; AXIN2; TCF7L2
    Glioma CALM3; PRKCB; CALML3; SOS1; MAPK1; NRAS; IGF1; CAMK2D; CALML5; TRP53
    Prostate cancer GSTP1; NDRG1; TRP53; TCF7; FOXO1; CPN1; PTEN; INSRR; MAP2K1; CCNE1
    Thyroid cancer MAP2K2; PAX8; MAPK1; NCOA4; RXRG; TCF7L2; PPARG; NRAS; MAP2K1; BRAF
    Melanoma MET; PDGFC; FGF19; PIK3R5; FGF13; BAD; PTEN; MAPK1; AKT2; FGF22
    Bladder cancer TRP53; ARAF; KRAS; ERBB2; DAPK2; HRAS; MMP1A; NRAS; RB1; E2F3
    Chronic myeloid leukemia BRAF; MECOM; PIK3CA; CTBP2; CBL; SHC3; CDK6; SMAD4; HRAS; AKT2
    Acute myeloid leukemia MAPK3; PIK3R3; PPARD; NRAS; SOS1; CCNA1; RARA; CEBPA; ARAF; CCND1
    Small cell lung cancer BIRC3; NFKB1; BIRC7; RARB; RB1; PIK3CG; LAMA1; LAMA5; AKT2; LAMB1
    Non-small cell lung cancer PLCG2; EML4; RASSF5; CCND1; HRAS; PIK3CD; RAF1; MAP2K2; NRAS; PRKCG
    Viral myocarditis HLA-DQA2; HLA-DOB; HLA-DQB1; CD28; SGCG; HLA-DRB1; HLA-DOA; CD40LG; CYCS; H2-AB1

    CCND1 has several biochemical functions, for example, cyclin-dependent protein serine/threonine kinase regulator activity, enzyme binding, histone deacetylase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCND1 itself. We selected most functions CCND1 had, and list some proteins which have the same functions with CCND1. You can find most of the proteins on our site.

    Function Related Protein
    cyclin-dependent protein serine/threonine kinase regulator activity CKS2; CCNL1A; CCNT2A; CCNE2; CCNT2B; CKS1B; PSTPIP2; CDK4; CCNL1; CCNL2
    enzyme binding TAL1; PPP3CB; CYB5A; SIRT1; C6orf211; DDX5; KIAA1967; APBA3; CDC20; AXIN2
    histone deacetylase binding TFAP4; NACC2; HDAC9; ZMYND15; RUNX2; TRAF6; NKX2-5; YWHAE; HES1; BRMS1L
    proline-rich region binding ABI2; PFN1; TCERG1; CYLD; ABL1; PRPF40A; CCND1; NEDD4; ITSN1; APBB1
    protein binding RHOJ; TSC1; FOS; PTGIS; TLX2; SNX17; MEMO1; Anks6; Reln; ING2
    protein complex binding MLKL; NSF; NCOA1; NFYB; SLC27A5; CASP8; C8G; ATF1; LZTFL1; TXN2
    protein kinase activity NTRK2B; CDK14; IKBKB; MAP3K5; VSIG8B; NRBP2; MAPK12A; NLK1; PDK3; LTK
    protein kinase binding DNM2; SPRED1; SYN1; PRKACA; MAPT; GSTP2; PPP1R12A; LAT; CALM; SQSTM1
    transcription corepressor activity KCNIP3; APEX1; KCNA3; CDYL; LDB1; CTBP2A; NRIP1; HDAC9; ZBTB32; SMYD1
    transcription factor binding PIAS2; BCL3; PDX1; ATG7; CTBP1; TRIB2; KAT2A; SMARCA4; SUFU; RNF4

    CCND1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCND1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCND1.

    CDK4; CDKN1A

    Tajiri, R; Ooi, A; et al. Intratumoral heterogeneous amplification of ERBB2 and subclonal genetic diversity in gastric cancers revealed by multiple ligation-dependent probe amplification and fluorescence in situ hybridization. HUMAN PATHOLOGY 45:725-734(2014).
    Rao, C; Lin, SL; et al. High Expression of IGFBP7 in Fibroblasts Induced by Colorectal Cancer Cells Is Co-Regulated by TGF-beta and Wnt Signaling in a Smad2/3-Dvl2/3-Dependent Manner. PLOS ONE 9:-(2014).

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