CCND1
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Official Full Name
cyclin D1
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Overview
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. -
Synonyms
CCND1; cyclin D1; BCL1; PRAD1; U21B31; D11S287E; B-cell CLL/lymphoma 1; G1/S-specific cyclin D1; cyclin D1 (PRAD1: parathyroid adenomatosis 1); parathyroid adenomatosis 1; BCL-1 oncogene; PRAD1 oncogene;
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- N/A
- N
- T7|His
- Involved Pathway
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- Interacting Protein
- CCND1 Related Articles
- CCND1 Related Signal Pathway
CCND1 involved in several pathways and played different roles in them. We selected most pathways CCND1 participated on our site, such as FoxO signaling pathway, Cell cycle, p signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCND1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| FoxO signaling pathway | SGK1;KLF2B;RAG2;HRASB;PRKAB1B;MAP2K2B;FBXO32;SOS1;CDKN1BA |
| Cell cycle | STAG2;BRCC3;CDC16;ABL1;GORASP1;ANAPC7;GADD45BA;CDKN2A;SGOL1 |
| p signaling pathway | CDK1;APAF1;CCNB3;RPRMA;GADD45AB;STEAP3;PTEN;RRM2B;SHISA5 |
| PIK-Akt signaling pathway | VEGFA;GNG11;MTCP1;HSP90B1;GH1;LAMA2;EPO;Fgf15;SGK1 |
| AMPK signaling pathway | FOXO1;IRS2;CAB39;ACACA;CPT1A;CAMKK1;PRKAG2;INS;ADRa1A |
| Wnt signaling pathway | FZD3;NFATC4;MAPK8;LEF1;PPP3R1;DVL3A;SENP2;WNT2;WNT7AA |
| Hippo signaling pathway | GLI2;TGFBR2;CCND1;BMP5;WNT2;WNT7B;PRKCZ;PPP2CB;WNT11 |
| Focal adhesion | IBSP;VWF;TNXB;ROCK2A;RHOAA;RHOB;GRB2A;PPP1CAB;PTEN |
| Jak-STAT signaling pathway | PIAS4A;NT5C3;CSF3R;GM2002;AKT3A;PIK3R3;IL23;IL2RG;IL9 |
| Prolactin signaling pathway | PIK3R1;INS1;AKT1;GALT;MAPK10;TH;MAP2K2;SOCS6;MAPK12 |
| Thyroid hormone signaling pathway | MTOR;ESR1;ATP1A2;ITGB3;MED12L;NRAS;PLN;TP53;PRKCA |
| Oxytocin signaling pathway | GUCY1B3;CACNG7;ITPR3;PIK3CG;CAMKK2;CALML3;ROCK2;CACNA2D3;CALM1 |
| Hepatitis B | FASLG;CREB5;PIK3CG;NFATC1;MAPK1;CASP8;PIK3R1;HBXIP;IFNA17 |
| Measles | STAT2;IL1A;IRAK4;OAS1;SH2D1A;Ifna15;TLR7;TRP53;CD3E |
| HTLV-I infection | WNT9A;TGFBR1;DLG1;HLA-DPA1;SPI1;PPP3CB;LCK;IL1R2;IKBKB |
| Pathways in cancer | FZD5;LEF1;LPAR3;NCOA4;RASSF5;CASP9;Fgf15;FASLG;WNT11 |
| Viral carcinogenesis | GRB2;DNAJA3;NRAS;CCND2;IRF3;CCNA1;GTF2H3;BAD;HIST1H4G |
| Proteoglycans in cancer | TP53;PDPK1;WNT16;PLCG2;FLNC;VTN;HSPB2;WNT5A;HCLS1 |
| MicroRNAs in cancer | CDCA5;HNRNPK;SOCS1;RPTOR;PLAU;PRKCA;CDC25A;SPRY2;DICER1 |
| Colorectal cancer | KRAS;RHOA;TGFBR1;MAPK8;TGFB2;AKT2;TRP53;TCF7L2;MAPK10 |
| Pancreatic cancer | AKT1;MAPK10;NFKB1;RAC2;IKBKG;RAC1;IKBKB;TGFB1;PIK3R5 |
| Endometrial cancer | MAPK3;BAD;SOS1;CTNNA3;PIK3CA;NRAS;PIK3R1;BRAF;PIK3CB |
| Glioma | RAF1;CALM2;NRAS;CALML3;CALM1;MTOR;PRKCG;SHC3;MAPK3 |
| Prostate cancer | RAF1;BAD;IGF1R;CREB3L2;TCF7;GSK3B;BCL2;MAPK3;CREB5 |
| Thyroid cancer | CCND1;CDH1;MAP2K1;TCF7;NRAS;PPARG;TRP53;BRAF;RXRB |
| Melanoma | BRAF;PIK3R5;PDGFRA;ARAF;MDM2;PIK3CB;PIK3CD;PIK3R2;PIK3R1 |
| Bladder cancer | RB1;KRAS;MAP2K2;MDM2;TP53;RASSF1;RAF1;FGFR3;DAPK3 |
| Chronic myeloid leukemia | RB1;AKT1;PIK3R2;SHC4;MECOM;TRP53;PIK3CB;GRB2;TP53 |
| Acute myeloid leukemia | MTOR;MYC;NRAS;CHUK;RUNX1T1;CCND1;FLT3;SPI1;RPS6KB2 |
| Small cell lung cancer | PIK3CD;NFKBIA;AKT1;MAX;CKS2;PIK3R3;PTGS2;BIRC7;BIRC8 |
| Non-small cell lung cancer | TP53;PDPK1;RXRG;SOS1;MAPK3;FHIT;TRP53;CCND1;HRAS |
| Viral myocarditis | CXADR;CD28;Casp3;HLA-G;RAC2;HLA-DQB1;CD40LG;CASP9;H2-Q10 |
CCND1 has several biochemical functions, for example, cyclin-dependent protein serine/threonine kinase regulator activity, enzyme binding, histone deacetylase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCND1 itself. We selected most functions CCND1 had, and list some proteins which have the same functions with CCND1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cyclin-dependent protein serine/threonine kinase regulator activity | CCNC;CCNL2;CCNK;CCNT2A;FAM58A;CCNT1;CKS2;CKS1B;CDK4 |
| enzyme binding | EGLN1;NOXA1;AKIRIN2;CTNNBL1;AXIN2;N4BP2L2;UGT1A6;CABYR;PHB |
| histone deacetylase binding | NKX2-5;HIF1A;XBP1;RUNX2;DDX20;RFXANK;KLF4;TFAP4;SRF |
| proline-rich region binding | TCERG1;YAP1;BAIAP2;CSK;PRPF40A;CYLD;WBP4;GAREM;APBB1 |
| protein binding | ITGA4;DLL1;PEG10;TRPM8;VAMP1;PNKP;RAPGEF6;PLEKHM1;KL |
| protein complex binding | UQCRC2;ANKRD32;CRHR1;PDX1;CRIPT;SREBF1;CFLAR;CCNE1;CALCA |
| protein kinase activity | GM7168;TBCK;PRKAG1;SGK2B;CSNK2A2A;GM4922;ADRBK2;HIPK3A;CAMKVB |
| protein kinase binding | RAD9A;DCX;CALM3;CNTLN;TICAM1;CDKN2B;CAMK2N1A;PRC1;SOCS1 |
| transcription corepressor activity | YY1;CDX2;NR0B2A;MXD1;ARHGAP35;SF1;NANOG;TRIM28;C1D |
| transcription factor binding | PARK7;SIRT2;E2F1;MYOCD;NFKB1;ARRB1;MDFI;SOX10;APBB2 |
CCND1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCND1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCND1.
CDK4; CDKN1A
Tajiri, R; Ooi, A; et al. Intratumoral heterogeneous amplification of ERBB2 and subclonal genetic diversity in gastric cancers revealed by multiple ligation-dependent probe amplification and fluorescence in situ hybridization. HUMAN PATHOLOGY 45:725-734(2014).
Rao, C; Lin, SL; et al. High Expression of IGFBP7 in Fibroblasts Induced by Colorectal Cancer Cells Is Co-Regulated by TGF-beta and Wnt Signaling in a Smad2/3-Dvl2/3-Dependent Manner. PLOS ONE 9:-(2014).
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