ccnd1
Share
  • Official Full Name
  • cyclin D1
  • Background
  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
  • Synonyms
  • CCND1; cyclin D1; BCL1; PRAD1; U21B31; D11S287E; B-cell CLL/lymphoma 1; G1/S-specific cyclin D1; cyclin D1 (PRAD1: parathyroid adenomatosis 1); parathyroid adenomatosis 1; BCL-1 oncogene; PRAD1 oncogene
Cat.#:CCND1-0658HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CCND1 Protein, GST-Tagged
+Inquiry
Cat.#:CDK4/CCND1-633HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human CDK4/CCND1, His-tagged
+Inquiry
Cat.#:CCND1-171HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human CCND1 protein, DDK-tagged
+Inquiry
Cat.#:CCND1-221HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCND1 protein, T7/His-tagged
+Inquiry
Cat.#:CCND1-23HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CCND1 protein, MYC/DDK-tagged
+Inquiry
Cat.#:CCND1-24HTag:flag
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human CCND1 protein, Flag-tagged
+Inquiry
Cat.#:CCND1-27520THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCND1, His-tagged
+Inquiry
Cat.#:CCND1-27756THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCND1
+Inquiry
Cat.#:CCND1-31773THTag:His
Source (Host):Species:Human
Product nameRecombinant Human Human CDK6, His-tagged
+Inquiry
Cat.#:CCND1-354HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCND1 protein, His/MBP-tagged
+Inquiry
Cat.#:CCND1-355HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCND1 protein, His/MBP-tagged
+Inquiry
Cat.#:IGLC1-14119HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IGLC1, His-tagged
+Inquiry
Cat.#:Ccnd1-2610MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ccnd1 protein, His-tagged
+Inquiry
Cat.#:CCND1-2988MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CCND1 Protein
+Inquiry
Cat.#:CCND1-1219RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CCND1 Protein
+Inquiry
Cat.#:Ccnd1-2611RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ccnd1 protein, His-tagged
+Inquiry
Cat.#:CCND1-698RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CCND1 Protein, His-tagged
+Inquiry
Cat.#:CCND1-2609CTag:His
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken CCND1 protein, His-tagged
+Inquiry
Cat.#:CCND1-6933CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CCND1
+Inquiry
Cat.#:CCND1-8654ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CCND1
+Inquiry
Cat.#:CCND1-2608CTag:His/T7
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle CCND1 protein, His & T7-tagged
+Inquiry
Cat.#:CCND1-1444HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Cyclin D1, GST-tagged
+Inquiry
Cat.#:CCND1-7713HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CCND1 293 Cell Lysate
+Inquiry

Involved Pathway

CCND1 involved in several pathways and played different roles in them. We selected most pathways CCND1 participated on our site, such as FoxO signaling pathway, Cell cycle, p signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCND1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
FoxO signaling pathway
PRKAB1A; MAP2K2; SIRT1; AKT2L; IKBKB; TGFB1; INS2; MAPK11; KLF2; AGAP2
Cell cycle
SMC1B; YWHAZ; POT1; NUPL2; SKA1; DHFR; PTTG2; NUDC; SMC1AL; MSH5
p signaling pathway
TNFRSF10B; PTENB; RFWD2; ZMAT3; BAI1; ATM; EI24; CYCSB; CCNE2; TP73
PIK-Akt signaling pathway
FGF6; GNG4; ITGA4; FGF19; PPP2R2D; PPP2R1B; ITGB3; IFNA7; GHR; TSC1
AMPK signaling pathway
ULK1; PPP2R2C; AKT3; CPT1B; CCNA2; PFKFB4; PRKAB1; CPT1A; CAMKK2; FBP2
Wnt signaling pathway
MAPK9; NFATC3; RUVBL1; RAC1B; TP53; PPARDB; FZD2; WNT11R; PPP3R1; CAMK2B1
Hippo signaling pathway
SCRIB; LLGL2; AMH; PPP2CB; TEAD2; WTIP; WWTR1; LLGL1; AJUBA; WNT5B
Focal adhesion
RAC3A; TNC; PTK2AB; BADB; GSK3AA; TLN1; PDPK1B; ITGA6B; COL2A1; MYL9A
Jak-STAT signaling pathway
LEPB; TP-1; Il23a; Il12b; LIFR; STAM2; RAF1B; PRP2; AKT2; GM-CSF; CISH
Prolactin signaling pathway
SOCS3; NEK3; SHC3; PRLR; GRB2; ESR2; GALT; MAPK1; KRAS; PIK3CG
Thyroid hormone signaling pathway
PLN; NOTCH3; ATP1B1; MED4; MAPK3; PIK3R1; FOXO1; MED12; PDPK1; SLC9A1
Oxytocin signaling pathway
RYR2; ITPR3; PLA2G4A; MAP2K5; PRKCA; PRKAA2; ACTB; PRKAB1; PPP1R12C; GUCY1B3
Hepatitis B
IKBKB; MAPK3; IKBKE; ELK1; PIK3CA; PIK3CD; APAF1; PTK2B; DDX3X; SMAD4
Measles
PIK3R2; HSPA1B; IL1A; IRAK1; IFNA8; TP73; PIK3CD; PIK3R3; HSPA2; IFNA21
HTLV-I infection
VDAC2; POLD2; RANBP1; TBPL1; RELB; WNT9A; BUB1B; PIK3R2; TBP; CDC20
Pathways in cancer
PRKACB; RHOA; PLCG1; CSF3R; FGF1; RAD51; TCF7; Flt3l; APPL1; PRKACG
Viral carcinogenesis
HIST1H2BL; CREB3L3; H2BFWT; TRADD; CDC42; CASP8; TRAF5; MRPS18B; DNAJA3; EIF2AK2
Proteoglycans in cancer
TLR4; STAT3; FZD1; MET; MSN; ARHGEF1; Casp3; PDCD4; FGFR1; IGF2
MicroRNAs in cancer
GLS2; TTC6; MMP16; FGFR3; PIK3R2; RDX; GRB2; BMI1; PLCG1; RASSF1
Colorectal cancer
APC; TGFBR1; DCC; PIK3CB; AXIN2; TGFB3; ARAF; RAC2; TGFB2; TGFBR2
Pancreatic cancer
MAPK8; PIK3R2; AKT2; RAC1; TGFA; STAT3; PIK3CB; BCL2L1; RALB; RALBP1
Endometrial cancer
HRAS; SOS1; ERBB2; MAP2K2; PIK3R2; PIK3R1; MAPK1; PIK3CD; NRAS; PIK3R5
Glioma
CAMK2D; MTOR; CALML3; RAF1; PIK3R2; ARAF; PIK3CG; PIK3R5; CALM4; CALM3
Prostate cancer
TRP53; NKX3; IKBKG; CREB5; FOXA1; PIK3R2; Ar; MAP2K2; PIK3CD; NKX3-1
Thyroid cancer
LEF1; TFG; BRAF; TCF7L2; CDH1; NRAS; KRAS; TRP53; RXRG; PPARG
Melanoma
FGF20; FGF10; PDGFD; FGF22; FGF9; NRAS; CDH1; FGF17; FGF11; MDM2
Bladder cancer
MAP2K2; RAF1; HRAS; NRAS; EGF; MAPK3; FGFR3; ARAF; E2F1; CXCL8
Chronic myeloid leukemia
MECOM; STAT5A; MAP2K2; AKT2; STAT5B; CDK6; NFKBIA; CBLC; PIK3CG; PIK3R2
Acute myeloid leukemia
GRB2; RELA; RUNX1; RARA; PIM2; LEF1; AKT3; PIM1; STAT5B; TCF7L2
Small cell lung cancer
ITGB1; AKT2; BIRC2; PTK2; APAF1; TRAF3; IKBKG; ITGA2B; BIRC8; PTGS2
Non-small cell lung cancer
RAF1; MAPK3; PIK3CA; PRKCA; HRAS; PDPK1; TRP53; ALK; MAP2K2; PLCG1
Viral myocarditis
H2-Q10; MYH7; CAV1; SGCD; HLA-DPA1; ITGB2; HLA-E; ABL1; HLA-DQA1; SGCA

Protein Function

CCND1 has several biochemical functions, for example, cyclin-dependent protein serine/threonine kinase regulator activity, enzyme binding, histone deacetylase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCND1 itself. We selected most functions CCND1 had, and list some proteins which have the same functions with CCND1. You can find most of the proteins on our site.
Function
Related Protein
Function cyclin-dependent protein serine/threonine kinase regulator activity
Related Protein CKS1B; CCNT1; CCNK; CKS2; CCNE1; CCNC; CCNL1; PSTPIP2; CDK4; CCNT2
Function enzyme binding
Related Protein NLRP1; ADORA2A; RYR2; SELS; ESR2; YES1; CA; PPP3CB; CUTA; SIRT1
Function histone deacetylase binding
Related Protein RAD9A; DDX20; SIX3; ANKRA2; ZMYND15; USF1; HDAC3; HEY2; KLF4; ZNF703
Function proline-rich region binding
Related Protein BAIAP2L1; APBB1; GAREM; ABI2; WBP4; NEDD4; ITSN1; TCERG1; CYLD; GHR
Function protein binding
Related Protein SSBP1; UQCRB; CDKN2AIP; SMC3; SRPK1; CCDC112; SOS1; HDDC2; FAM54A; UCHL1
Function protein complex binding
Related Protein GIT1; UGT1A6A; VPS28; CRTAP; STRN4; Cel; CALY; ANKRD32; GRIN2A; WRN
Function protein kinase activity
Related Protein GSG2; GRK7B; RPS6KAL; PRKCDA; WEE2; GRK7A; CSNK1G2A; CAMK2D1; SRPK1; TNNI3K
Function protein kinase binding
Related Protein CLTC; IBTK; FAM83B; HNRNPA0; CDK5RAP1; IL31RA; DOK7; NEFH; VRK2; PGAM1
Function transcription corepressor activity
Related Protein ZMYND11; SSX2; TBL1X; CCND1; DR1; THRB; FEV; SKOR1A; SKIL; ERF
Function transcription factor binding
Related Protein MAPK1; BRD7; C1QBP; MED25; IFI16; EPN1; FHL2; HDAC3; TRERF1; TFAP2A

Interacting Protein

CCND1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCND1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCND1.
CDK4; CDKN1A

CCND1 Related Articles

Tajiri, R; Ooi, A; et al. Intratumoral heterogeneous amplification of ERBB2 and subclonal genetic diversity in gastric cancers revealed by multiple ligation-dependent probe amplification and fluorescence in situ hybridization. HUMAN PATHOLOGY 45:725-734(2014).
Rao, C; Lin, SL; et al. High Expression of IGFBP7 in Fibroblasts Induced by Colorectal Cancer Cells Is Co-Regulated by TGF-beta and Wnt Signaling in a Smad2/3-Dvl2/3-Dependent Manner. PLOS ONE 9:-(2014).