ENG
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Official Full Name
endoglin
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Overview
This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013] -
Synonyms
ENG; endoglin; END; HHT1; ORW1; CD105 antigen; ORW; CD105;
- Recombinant Proteins
- Cell & Tissue Lysates
- Others
- Antibody
- Protein Pre-coupled Magnetic Beads
- Chicken
- Homo sapiens (Human)
- Human
- Mouse
- Rat
- Sus scrofa (Pig)
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Human Cell
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Rabbit
- Sf9 Insect Cell
- C
- His
- Fc Chimera
- GST
- hFc
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- Strep II
- Trx|His
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | ENG-26364TH | Recombinant Human ENG | N/A | |||
Human | ENG-133H | Recombinant Human Endoglin,Sf9 | Sf9 Insect Cell | N/A | ||
Human | ENG-132H | Recombinant Human Endoglin | E.coli | N/A | ||
Human | ENG-63H | Active Recombinant Human ENG protein, hFc-tagged | HEK293 | hFc | Met1-Gly586 | |
Human | ENG-783H | Recombinant Human ENG Protein, Trx-6His-tagged | E.coli | Trx/His | ||
Human | ENG-3146H | Recombinant Human ENG protein(Met1-Gly586), His-tagged | HEK293 | C-His | Met1-Gly586 | |
Human | ENG-428H | Recombinant Human endoglin, His-tagged | E.coli | His | ||
Human | ENG-4917H | Recombinant Human Endoglin | Sf9 Insect Cell | N/A | ||
Human | ENG-12449H | Recombinant Human ENG, GST-tagged | E.coli | GST | C-term-49a.a. | |
Human | ENG-300H | Recombinant Human ENG, StrepII-tagged | Human Cell | Strep II | 26-585, 560 a.a. | |
Human | ENG-2457HCL | Recombinant Human ENG cell lysate | Human Cell | N/A | ||
Human | ENG-0897H | Recombinant Human ENG Protein (Thr27-Gly581), N-His tagged | E.coli | N-His | Thr27-Gly581 | |
Human | ENG-1425H | Recombinant Human ENG Protein, His-tagged | E.coli | N-His | Thr336-Phe450 | |
Human | ENG-027H | Recombinant Human ENG Protein, C-His-tagged | E.coli | C-His | ||
Human | ENG-813H | Recombinant Human ENG protein, His-Avi-tagged | HEK293 | His-Avi | Glu26-Gly586 | |
Human | ENG-5969H | Recombinant Human ENG Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK | ||
Human | ENG-4297HF | Recombinant Full Length Human ENG Protein, GST-tagged | In Vitro Cell Free System | GST | 658 amino acids | |
Human | CDA094P | Recombinant Human CD-105 Protein | E.coli | N/A | ||
Human | ENG-4076H | Recombinant Human ENG Protein (Met1-Gly586), C-His tagged | Mammalian cells | C-His | Met1-Gly586 | |
Mouse | Eng-449M | Active Recombinant Mouse Endoglin | Mammalian cells | N/A | ||
Mouse | Eng-982M | Recombinant Mouse Endoglin | Insect Cell | N/A | ||
Mouse | Eng-3289M | Active Recombinant Mouse Eng protein, His-tagged | HEK293 | His | Met1-Gly580 | |
Mouse | Eng-5693M | Recombinant Mouse Eng protein, His-tagged | E.coli | His | Thr336~Phe450 (Accession # Q63961) | |
Mouse | ENG-2267MCL | Recombinant Mouse ENG cell lysate | Human Cell | N/A | ||
Mouse | Eng-10540M | Recombinant Mouse Eng Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | Eng-7199M | Recombinant Mouse Eng Protein | Insect Cell | |||
Mouse | CAB11530RM | Rabbit Anti-Mouse Endoglin Monoclonal Antibody | Rabbit | N/A | ||
Mouse | Eng-2823M | Recombinant Mouse Eng Protein, Myc/DDK-tagged | HEK293T | Myc/DDK | ||
Mouse | Eng-10540M-B | Recombinant Mouse Eng Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | Eng-638R | Active Recombinant Rat Eng, Fc Chimera | Mammalian cells | Fc Chimera | ||
Rat | Eng-5694R | Recombinant Rat Eng protein, His-tagged | E.coli | His | Glu26~Pro136 (Accession # Q6Q3E8) | |
Rat | Eng-25R | Recombinant Rat Eng Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | Eng-25R-B | Recombinant Rat Eng Protein Pre-coupled Magnetic Beads | HEK293 | |||
Homo sapiens (Human) | RFL23630HF | Recombinant Full Length Human Endoglin(Eng) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (26-658) | |
Sus scrofa (Pig) | RFL28093SF | Recombinant Full Length Pig Endoglin(Eng) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (25-653) | |
Chicken | ENG-3642C | Recombinant Chicken ENG | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- ENG Related Articles
- ENG Related Research Area
ENG involved in several pathways and played different roles in them. We selected most pathways ENG participated on our site, such as HIF-1-alpha transcription factor network, TGF Beta Signaling Pathway, TGF-beta Receptor Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ENG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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HIF-1-alpha transcription factor network | TFF3;ADM;PLIN2;ENG;CP;CITED2;NDRG1;NPM1;GATA2 |
TGF Beta Signaling Pathway | FST;NOG;ZNF423;LEFTY1;ZFP423;TGFBR3;ENG;RUNX3;FOXH1 |
TGF-beta Receptor Signaling Pathway | GIPC1;STAMBPL1;CTCF;STK11IP;ZEB2A;COPS5;RUNX2A;TRAP1;NFYBB |
ENG has several biochemical functions, for example, contributes_to BMP binding, activin binding, galactose binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ENG itself. We selected most functions ENG had, and list some proteins which have the same functions with ENG. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
contributes_to BMP binding | |
activin binding | FST;SMAD7;TGFBR3;SMURF1;FKBP1A;ACVR1;ACVRL1;ENG;ACVR2B |
galactose binding | LGALS9;CLEC4F;GALK1;COLEC12;ENG |
glycosaminoglycan binding | CCDC80;EPYC;PODXL2;VIT;EGFLAM;TGFBR2;BGN;SPOCK3;ENG |
protein binding | TRIM29;RHOBTB3;GUCY2C;PTPN1;FAIM;CCNL2;EPHB4;PBLD;SCARA3 |
protein homodimerization activity | HMGCL;TMEM192;CCL5;TPD52L1;BOKB;SLC6A4;GIPC1;LILRB1;FZD1 |
transforming growth factor beta binding | TGFB3;TGFBR1;VASN;LTBP1;LTBP4;ENG;TGFBR3;ACVR1;HYAL2 |
contributes_to transforming growth factor beta binding | ENG;TGFBR2;TGFBR1;TGFBR3 |
transforming growth factor beta receptor, cytoplasmic mediator activity | CDKN1B;ENG |
transforming growth factor beta-activated receptor activity | ENG;LTBP1;BMPR2B;ACVRL1;BMPR2A;TGFBR1;TGFBR3;TGFBR2 |
transmembrane signaling receptor activity | BCAM;P2RX5;IL27RA;CD5;EMR4;CALCRLA;VIPR1B;CD72;ENG |
type I transforming growth factor beta receptor binding | SMAD7;TGFB1;TGFBR2;ENG;TGFB3;FKBP1A;SMAD2;SNX25;SMAD6 |
type II transforming growth factor beta receptor binding | BAMBI;TGFB1A;TGFB3;TGFBR1;TGFB2;TGFB1;ENG;TGFBR3 |
ENG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ENG here. Most of them are supplied by our site. Hope this information will be useful for your research of ENG.
ITGA5; ITGB1; TGFB1; ganglioside_gm1; ARRB2; MMP14; ybgA; lutB; purH
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