CD82
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Official Full Name
CD82 molecule
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Overview
This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
CD82; CD82 molecule; R2; 4F9; C33; IA4; ST6; GR15; KAI1; SAR2; TSPAN27; CD82 antigen; tspan-27; C33 antigen; tetraspanin-27; inducible membrane protein R2; metastasis suppressor Kangai-1; kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4));
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rattus norvegicus (Rat)
- E.coli
- E.coli expression system
- HEK293
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Fc
- GST
- His
- Avi
- SUMO
- Non
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | CD82-0867H | Recombinant Human CD82 Protein, GST-Tagged | Wheat Germ | GST |
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| Human | CD82-27889TH | Recombinant Human CD82 | Wheat Germ | Non | 267 amino acids |
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| Human | CD82-3969H | Recombinant Human CD82 protein(Gly111-Leu228), His-tagged | HEK293 | His | Gly111-Leu228 | |
| Human | CD82-1960HCL | Recombinant Human CD82 cell lysate | Human Cell | Non |
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| Human | CD82-3970H | Recombinant Human CD82(Gly103-Gln225) Protein, N-Fc-tagged | HEK293 | Fc | Gly103-Gln225 |
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| Human | CD82-3070HF | Recombinant Full Length Human CD82 Protein, GST-tagged | In Vitro Cell Free System | GST | 267 amino acids |
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| Human | CD82-67HF | Recombinant Full Length Human CD82 Protein | In Vitro Cell Free System | 267 amino acids |
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| Human | CD82-127H | Recombinant Human CD82 protein, His-tagged | E.coli | His | 35-264 aa |
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| Human | CD82-146H | Recombinant Human CD82 Protein, C-His-tagged | E.coli | His |
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| Human | CD82-3721H | Recombinant Human CD82 Protein (Gly111-Leu228), C-His tagged | Mammalian cells | His | Gly111-Leu228 |
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| Mouse | CD82-3111M | Recombinant Mouse CD82 Protein | Mammalian Cell | His |
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| Mouse | CD82-1470M-B | Recombinant Mouse CD82 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | CD82-1470M | Recombinant Mouse CD82 Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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| Mouse | Cd82-2674M | Recombinant Mouse Cd82 protein, His-SUMO-tagged | E.coli | His&SUMO | 111-227aa |
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| Homo sapiens (Human) | RFL30269HF | Recombinant Full Length Human Cd82 Antigen(Cd82) Protein, His-Tagged | E.coli expression system | His | Full Length (1-267) |
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| Mus musculus (Mouse) | RFL2400MF | Recombinant Full Length Mouse Cd82 Antigen(Cd82) Protein, His-Tagged | E.coli expression system | His | Full Length (1-266) |
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| Rattus norvegicus (Rat) | RFL11281RF | Recombinant Full Length Rat Cd82 Antigen(Cd82) Protein, His-Tagged | E.coli expression system | His | Full Length (1-266) |
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| Chicken | CD82-1848C | Recombinant Chicken CD82 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
CD82 involved in several pathways and played different roles in them. We selected most pathways CD82 participated on our site, such as Direct p53 effectors, Integrated Pancreatic Cancer Pathway, p53 signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD82 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Direct p53 effectors | CCNK;DUSP1;PLK3;BCL2L14;DDB2;CTSD;GADD45A;DDX5;HIC1 |
| Integrated Pancreatic Cancer Pathway | AGA;JUND;RAPGEF3;IL11;RB1CC1;FKBP3;NOXA1;MAPK4;PPP1R13L |
| p53 signaling pathway | GADD45G;CD82;SESN3 |
CD82 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD82 itself. We selected most functions CD82 had, and list some proteins which have the same functions with CD82. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MAP1S;ANKRD49;POLA1;ADRBK1;L3MBTL3;REST;ICAM4;CTDSP2;MT2A |
CD82 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD82 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD82.
VANGL1; CD19; NFKB1; NUP88; q9wmx2-pro_0000037550
Research Area
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Q&As (7)
Ask a questionGenetic mutations in CD82 can lead to reduced tumor-suppressive functions, enhancing the risk of cancer spread.
Targeting CD82 in cancer therapy could exploit its tumor-suppressive properties to prevent metastasis.
CD82 collaborates with other membrane proteins to regulate various signaling pathways, impacting cell behavior.
CD82, a member of the tetraspanin family, is involved in modulating cell signaling and intercellular communication.
Altered CD82 activity can influence immune cell interactions and responses.
CD82 acts as a tumor suppressor, inhibiting cancer cell migration and metastasis.
It plays a crucial role in regulating cell migration and adhesion, key processes in tissue organization and wound healing.
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