Recombinant Human CD82
Cat.No. : | CD82-27889TH |
Product Overview : | Recombinant full length Human CD82 with N terminal proprietary tag; Predicted MWt 55.11 kDa. |
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Description : | This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
Protein length : | 267 amino acids |
Molecular Weight : | 55.110kDa inclusive of tags |
Source : | Wheat germ |
Tissue specificity : | Lymphoid specific. |
Form : | Liquid |
Purity : | Proprietary Purification |
Storage buffer : | pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | MGSACIKVTKYFLFLFNLIFFILGAVILGFGVWILADKSS FISVLQTSSSSLRMGAYVFIGVGAVTMLMGFLGCIGAVNE VRCLLGLYFAFLLLILIAQVTAGALFYFNMGKLKQEMGGI VTELIRDYNSSREDSLQDAWDYVQAQVKCCGWVSFYNWTD NAELMNRPEVTYPCSCEVKGEEDNSLSVRKGFCEAPGNRT QSGNHPEDWPVYQEGCMEKVQAWLQENLGIILGVGVGVAI VELLGMVLSICLCRHVHSEDYSKVPKY |
Sequence Similarities : | Belongs to the tetraspanin (TM4SF) family. |
Tag : | Non |
Gene Name : | CD82 CD82 molecule [ Homo sapiens ] |
Official Symbol : | CD82 |
Synonyms : | CD82; CD82 molecule; CD82 antigen , KAI1, kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and IA4)) , ST6; CD82 antigen; IA4; R2; R2 leukocyte antigen; suppression of tumorigenicit |
Gene ID : | 3732 |
mRNA Refseq : | NM_001024844 |
Protein Refseq : | NP_001020015 |
MIM : | 600623 |
Uniprot ID : | P27701 |
Chromosome Location : | 11p11.2 |
Pathway : | Direct p53 effectors, organism-specific biosystem; p53 signaling pathway, organism-specific biosystem; p53 signaling pathway, conserved biosystem; |
Function : | protein binding; |
Products Types
◆ Recombinant Protein | ||
CD82-1470M | Recombinant Mouse CD82 Protein, His (Fc)-Avi-tagged | +Inquiry |
CD82-3969H | Recombinant Human CD82 protein(Gly111-Leu228), His-tagged | +Inquiry |
CD82-0867H | Recombinant Human CD82 Protein, GST-Tagged | +Inquiry |
CD82-146H | Recombinant Human CD82 Protein, C-His-tagged | +Inquiry |
CD82-3111M | Recombinant Mouse CD82 Protein | +Inquiry |
◆ Lysates | ||
CD82-1960HCL | Recombinant Human CD82 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Write a reviewIntegral to our research. Highly recommended service.
Exceptional accuracy and support. A research necessity.
Boosts research efficiency. Contributes to discoveries.
Q&As (7)
Ask a questionGenetic mutations in CD82 can lead to reduced tumor-suppressive functions, enhancing the risk of cancer spread.
Targeting CD82 in cancer therapy could exploit its tumor-suppressive properties to prevent metastasis.
CD82 collaborates with other membrane proteins to regulate various signaling pathways, impacting cell behavior.
CD82, a member of the tetraspanin family, is involved in modulating cell signaling and intercellular communication.
Altered CD82 activity can influence immune cell interactions and responses.
CD82 acts as a tumor suppressor, inhibiting cancer cell migration and metastasis.
It plays a crucial role in regulating cell migration and adhesion, key processes in tissue organization and wound healing.
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