Recombinant Human CD82

Cat.No. : CD82-27889TH
Product Overview : Recombinant full length Human CD82 with N terminal proprietary tag; Predicted MWt 55.11 kDa.
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Description : This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Protein length : 267 amino acids
Molecular Weight : 55.110kDa inclusive of tags
Source : Wheat germ
Tissue specificity : Lymphoid specific.
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : MGSACIKVTKYFLFLFNLIFFILGAVILGFGVWILADKSS FISVLQTSSSSLRMGAYVFIGVGAVTMLMGFLGCIGAVNE VRCLLGLYFAFLLLILIAQVTAGALFYFNMGKLKQEMGGI VTELIRDYNSSREDSLQDAWDYVQAQVKCCGWVSFYNWTD NAELMNRPEVTYPCSCEVKGEEDNSLSVRKGFCEAPGNRT QSGNHPEDWPVYQEGCMEKVQAWLQENLGIILGVGVGVAI VELLGMVLSICLCRHVHSEDYSKVPKY
Sequence Similarities : Belongs to the tetraspanin (TM4SF) family.
Tag : Non
Gene Name : CD82 CD82 molecule [ Homo sapiens ]
Official Symbol : CD82
Synonyms : CD82; CD82 molecule; CD82 antigen , KAI1, kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and IA4)) , ST6; CD82 antigen; IA4; R2; R2 leukocyte antigen; suppression of tumorigenicit
Gene ID : 3732
mRNA Refseq : NM_001024844
Protein Refseq : NP_001020015
MIM : 600623
Uniprot ID : P27701
Chromosome Location : 11p11.2
Pathway : Direct p53 effectors, organism-specific biosystem; p53 signaling pathway, organism-specific biosystem; p53 signaling pathway, conserved biosystem;
Function : protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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02/28/2021

    Integral to our research. Highly recommended service.

    10/22/2020

      Exceptional accuracy and support. A research necessity.

      08/26/2018

        Boosts research efficiency. Contributes to discoveries.

        Q&As (7)

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        How do genetic variations in CD82 affect cancer progression? 02/19/2023

        Genetic mutations in CD82 can lead to reduced tumor-suppressive functions, enhancing the risk of cancer spread.

        What potential therapeutic applications arise from targeting CD82 in cancer treatment? 09/15/2022

        Targeting CD82 in cancer therapy could exploit its tumor-suppressive properties to prevent metastasis.

        How does CD82 interact with other membrane proteins in signaling pathways? 10/07/2020

        CD82 collaborates with other membrane proteins to regulate various signaling pathways, impacting cell behavior.

        What is the primary role of CD82 in cell signaling and communication? 11/09/2019

        CD82, a member of the tetraspanin family, is involved in modulating cell signaling and intercellular communication.

        What is the impact of altered CD82 activity on immune response? 11/24/2018

        Altered CD82 activity can influence immune cell interactions and responses.

        What role does CD82 play in tumor suppression and metastasis prevention? 06/22/2017

        CD82 acts as a tumor suppressor, inhibiting cancer cell migration and metastasis.

        How does CD82 contribute to the regulation of cell migration and adhesion? 06/12/2017

        It plays a crucial role in regulating cell migration and adhesion, key processes in tissue organization and wound healing.

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