cdc42

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cdc42

Official Full Name cell division cycle 42
Background The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013]
Synonyms CDC42; cell division cycle 42; G25K; CDC42Hs; cell division control protein 42 homolog; G25K GTP-binding protein; GTP-binding protein, 25kD; growth-regulating protein; GTP binding protein, 25kDa; small GTP binding protein CDC42; dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD)); dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD));
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • pstS1
    • MYC/DDK
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CDC42-0934H Recombinant Human CDC42 Protein, GST-Tagged Wheat Germ GST
    Human CDC42-0936H Recombinant Human CDC42 Protein, GST-pstS1-Tagged Wheat Germ GST/pstS1
    Human CDC42-1023H Recombinant Human Cell Division Cycle 42, GST-tagged E.coli GST
    Human CDC42-1024H Recombinant Human Cell Division Cycle 42 E.coli N/A
    Human CDC42-11008H Recombinant Human CDC42, GST-tagged E.coli GST
    Human CDC42-1394H Recombinant Human Cell Division Cycle 42, T7-tagged E.coli T7
    Human CDC42-1579H Recombinant Human Cell Division Cycle 42 (GTP binding protein, 25kDa), GST-tagged E.coli GST
    Human CDC42-1712H Recombinant Human CDC42 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CDC42-1806H Recombinant Human CDC42, GST tagged E.coli GST
    Human CDC42-2634H Recombinant Human CDC42 protein, His-tagged E.coli His
    Human CDC42-2635H Recombinant Human CDC42 protein, GST-tagged E.coli GST
    Human CDC42-2636H Recombinant Human CDC42(T17N) protein, GST-tagged E.coli GST
    Human CDC42-2637H Recombinant Human CDC42(Q61L) protein, His-tagged E.coli His
    Human CDC42-26610TH Recombinant Human CDC42 E.coli N/A
    Human CDC42-26651TH Recombinant Human CDC42, T7 -tagged E.coli T7
    Human CDC42-4183H Recombinant Human CDC42 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CDC42-6646H Recombinant Human CDC42 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CDC42-7033H Recombinant Human CDC42, GST/His-tagged E.coli GST/His
    Human CDC42-7655HCL Recombinant Human CDC42 293 Cell Lysate HEK293 N/A
    Mouse CDC42-3139M Recombinant Mouse CDC42 Protein Mammalian Cell His
    Mouse Cdc42-856M Recombinant Mouse Cdc42 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rat CDC42-1277R Recombinant Rat CDC42 Protein Mammalian Cell His
    Cynomolgus Monkey CDC42-395C Recombinant Cynomolgus CDC42 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque CDC42-763R Recombinant Rhesus monkey CDC42 Protein, His-tagged Mammalian Cell His
    Chicken CDC42-6605C Recombinant Chicken CDC42 Mammalian Cell His
    Zebrafish CDC42-10904Z Recombinant Zebrafish CDC42 Mammalian Cell His
    Kit-0190 Cdc42 G-LISA Activation Assay Kit (Colorimetric) N/A
    Kit-0191 Cdc42 G-LISA Activation Assay Kit (Colorimetric) II N/A

    cdc42 involved in several pathways and played different roles in them. We selected most pathways cdc42 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with cdc42 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway MAPK14B; RAP1AB; GADD45BB; MEF2CB; PDGFAA; LAMTOR3; MECOM; FOS; NTF3; FASLG
    Ras signaling pathway ELK1; PLCG2; PIK3CG; MRAS; GNG7; GRIN1; MET; PAK1; PAK3; MLLT4
    Rap signaling pathway RRAS; PIK3R3; FGF3; MAPK1; SIPA1L2; MAGI2; Pdgfa&Pdgfb; RAPGEF6; RAP1A; THBS1
    Chemokine signaling pathway GRK7; VAV1; CCL3; PAK1; CCL19; JAK3; CXCR4; GM13304; GNG11; ITK
    Endocytosis KITB; CXCR4B; FLT1; HLA-B; ARRB2A; FAM125A; SNX1A; WASH1; CYTH1B; WAS
    Axon guidance KCNQ2; CLASP1; SPRED2; AP2B1; CXCR4; SDCBP; EPHA10; EPHB4B; EPHB6; ITSN1
    VEGF signaling pathway PIK3CA; CDC42L2; PRKCBB; PPP3CC; AKT2; SH2D2A; PLA2G4D; RAC3; PXNA; RAC1B
    Focal adhesion PTK2AB; PRKCG; RAC3A; ROCK2; HRASA; FN1; ROCK1; ITGA3B; BADB; ARHGAP5
    Adherens junction ACTN2B; CTNNA2; INSRA; FGFR1A; TCF7L2; SSX2IP; WASF3; EGFR; PTBP3; SNAI1
    Tight junction MYH6; PRKCA; YBX3; PRKCH; SHROOM4; CLDN15LB; CLDNG; CLDN5B; INADL; PPP2R1A
    T cell receptor signaling pathway SHB; KRAS; MAPK9; CD8B; SLA1; CD247; NRAS; PPP3R1; CD3E; CD3D; GRAP2
    Fc gamma R-mediated phagocytosis AKT1; LAT; WASF2; VAV3; PPAP2B; MARCKSL1; PLA2G4F; cgr2b; FCGR2A; PLCG1
    Leukocyte transendothelial migration PLCG2; PIK3CB; MYL2; VAV2; VASP; PRKCG; PIK3R5; RHOH; NOX3; ROCK2
    Neurotrophin signaling pathway IRAK4; PTPN11; RPS6KA6; RAP1A; MATK; BCL2; TP53; TRP53; NGFR; MAP3K1
    Regulation of actin cytoskeleton PPP1CC; RAC3B; FGFR1; ARHGEF7A; RAC1B; FGF21; ITGA2B; ACTN3A; MYL2B; PPP1CA
    GnRH signaling pathway LHBETA1; CALM1B; GRB2A; CAMK2B1; MAP3K4; CALM3B; RAF1B; GNRHR4; FSHB; PRKACA
    Non-alcoholic fatty liver disease (NAFLD) NDUFB6; PIK3CG; UQCR10; NDUFA1; NR1H3; LEP; NDUFB3; COX4I2; IL-8; TRAF2
    Bacterial invasion of epithelial cells PIK3R1; WASF2; SEPT2; ELMO1; ACTB; ARPC3; ARPC5; RHOG; SEPT9; CTNNA1
    Epithelial cell signaling in Helicobacter pylori infection ATP6V1C2; RELA; MAPK13; PLCG1; MAPK10; ATP6V0A4; MAP2K4; ATP6V1H; ATP6V1G3; F11R
    Pathogenic Escherichia coli infection TUBAL3; TLR5; TUBA3E; TUBA8; TUBA3C; TUBB6; WASL; ARHGEF2; CD14; WAS
    Shigellosis ACTB; U2AF1; IKBKG; RIPK2; ITGA5; MAD2L2; FBXW11; MAPK12; ATG5; ACTG1
    Salmonella infection NOS2B; IFNG1-2; TLR5B; MAPK12B; ACTG1; PFN4; FLNA; IL6; TLR5; MAPK8B
    Pathways in cancer PIAS2; EGLN2; Pdgfa&Pdgfb; FIGF; WNT9B; RASSF5; MTOR; F2R; GNG3; RAC1
    Viral carcinogenesis CCNA1; SKP2; YWHAZ; CREB3L1; HDAC8; TTC6; BAD; GTF2H4; ACTN4; HIST1H2BO
    Proteoglycans in cancer PPP1CC; PLCG2; FZD1; CD44; RAF1; MAPK13; MAPK3; WNT2; MAP2K2; HSPG2
    Renal cell carcinoma ARAF; FLCN; MAPK3; PIK3CD; GRB2; MAP2K2; AKT1; PTPN11; PAK7; PAK1
    Pancreatic cancer NFKB1; MAPK1; AKT1; ERBB2; RAD51; RALBP1; RAC1; RALGDS; MAPK3; RALB

    cdc42 has several biochemical functions, for example, GTP binding, GTP-dependent protein binding, GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by cdc42 itself. We selected most functions cdc42 had, and list some proteins which have the same functions with cdc42. You can find most of the proteins on our site.

    Function Related Protein
    GTP binding EHD3; RHOB; RASL11A; SUCLG1; ASCL1B; RABL5; GNA15.4; RAB8A; RAB1A; GNAIA
    GTP-dependent protein binding AP1G1; AP3B1; RAB32; RASGRP4; RAPGEF5; CDC42; GCH1; GCHFR; HPS6; PPIAL4A
    GTPase activity RAB15; RAB12; RAB5B; RHOQ; ARHGAP5; RAP1GAP; EFTUD2; EEF1A1B; RAB34A; GNAI2A
    apolipoprotein A-I receptor binding CDC42; APOA1; NR1H2
    identical protein binding BIN1; UAP1; BCHE; FHL2; MIEF1; PARP1; NUDT16; SH3GL1; PTPRG; PSMA7
    mitogen-activated protein kinase kinase kinase binding MAPK9; DUSP19; TCF3; TRAF2; MAPK8IP3; PPEF2; CDC37; MAP4K2; CDC42; MAPK1
    protein binding CRYBA4; FLNA; NR1H2; L3MBTL1; TCEB1; NTN1; VMP1; SKI; ROBO1; SPINLW1
    protein kinase binding CCNT2A; SV2A; TRIM6; FBXW5; CASP9; PRKAB1; CACNB2; CDC42; PLK1; NPM1
    thioesterase binding CALM1; TRAF2; TRAF3; TRAF6; TRAF1; TRAF5; CDC42; CALM3; TRAF4; HAUS7
    ubiquitin protein ligase activity UBE2KB; MED10; ANKIB1A; RABGEF1; MED23; FBXO40; UBE2NA; G2E3; RNF19B; UBE2V2

    cdc42 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cdc42 here. Most of them are supplied by our site. Hope this information will be useful for your research of cdc42.

    PAK1; WAS

    Matsuda, T; Yanase, S; et al. The immunosenescence-related gene Zizimin2 is associated with early bone marrow B cell development and marginal zone B cell formation. IMMUNITY & AGEING 12:-(2015).
    Tang, QH; Liu, ZY; et al. Involvement of activation of C-met signaling pathway in CD151-induced HUVECs angiogenesis. JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES 35:35-41(2015).

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