Recombinant Human DNMT3B Protein, His (Fc)-Avi-tagged

Cat.No. : DNMT3B-780H
Product Overview : Recombinant Human DNMT3B with His (Fc)-Avi tag was expressed and purified
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Source : HEK293
Species : Human
Tag : His&Fc&Avi
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method
Purity : ≥85% by SDS-PAGE
Stability : Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
Storage Buffer : PBS buffer
Gene Name : DNMT3B DNA methyltransferase 3 beta [ Homo sapiens (human) ]
Official Symbol : DNMT3B
Synonyms : ICF; ICF1; FSHD4; M.HsaIIIB
Gene ID : 1789
mRNA Refseq : NM_006892.4
Protein Refseq : NP_008823.1
MIM : 602900
UniProt ID : Q9UBC3

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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Reviews
11/09/2020

    The DNMT3B protein is of exceptional quality and has proven to be an ideal choice to meet my experimental requirements.

    09/10/2020

      With its consistent and outstanding results, the DNMT3B protein is an indispensable tool that I highly recommend for researchers in need of reliable and precise protein analysis.

      04/23/2019

        Its purity and reliability have consistently resulted in successful outcomes in my research projects, providing me with accurate and reproducible data.

        Q&As (5)

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        What are the potential side effects of targeting DNMT3B for therapeutic purposes? 12/04/2022

        Targeting DNMT3B for therapeutic purposes may lead to off-target effects and unintended changes in DNA methylation, potentially causing adverse effects on normal cellular function and gene expression.

        Are there any genetic disorders associated with mutations in the DNMT3B gene? 03/29/2021

        Yes, mutations in the DNMT3B gene are linked to a rare genetic disorder called ICF (Immunodeficiency, Centromeric instability, Facial anomalies) syndrome, characterized by immune system deficiencies, facial abnormalities, and unstable centromeric regions in chromosomes.

        Can DNMT3B protein be used as a potential biomarker for cancer diagnosis or prognosis? 11/08/2020

        Research has shown that alterations in DNMT3B expression or activity can be associated with various types of cancer, making it a potential biomarker for cancer diagnosis, prognosis, and treatment response.

        How does DNMT3B protein contribute to epigenetic regulation in cells? 09/21/2018

        DNMT3B plays a crucial role in establishing de novo DNA methylation patterns during embryonic development and cell differentiation, contributing to the epigenetic regulation of gene expression.

        What are the therapeutic implications of targeting DNMT3B in cancer treatment? 02/03/2018

        Inhibition of DNMT3B activity through targeted therapy or epigenetic modifying agents has been explored as a potential treatment strategy to reverse abnormal DNA methylation patterns and restore normal gene expression in cancer cells.

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