Recombinant Human DNMT3B Protein, His (Fc)-Avi-tagged
Cat.No. : | DNMT3B-780H |
Product Overview : | Recombinant Human DNMT3B with His (Fc)-Avi tag was expressed and purified |
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Source : | HEK293 |
Species : | Human |
Tag : | His&Fc&Avi |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method |
Purity : | ≥85% by SDS-PAGE |
Stability : | Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | PBS buffer |
Gene Name : | DNMT3B DNA methyltransferase 3 beta [ Homo sapiens (human) ] |
Official Symbol : | DNMT3B |
Synonyms : | ICF; ICF1; FSHD4; M.HsaIIIB |
Gene ID : | 1789 |
mRNA Refseq : | NM_006892.4 |
Protein Refseq : | NP_008823.1 |
MIM : | 602900 |
UniProt ID : | Q9UBC3 |
Products Types
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DNMT3B-895H | Recombinant Human DNMT3B Protein, His-tagged | +Inquiry |
◆ Lysates | ||
DNMT3B-6854HCL | Recombinant Human DNMT3B 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-1716 | DNMT3B Chemiluminescent Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewThe DNMT3B protein is of exceptional quality and has proven to be an ideal choice to meet my experimental requirements.
With its consistent and outstanding results, the DNMT3B protein is an indispensable tool that I highly recommend for researchers in need of reliable and precise protein analysis.
Its purity and reliability have consistently resulted in successful outcomes in my research projects, providing me with accurate and reproducible data.
Q&As (5)
Ask a questionTargeting DNMT3B for therapeutic purposes may lead to off-target effects and unintended changes in DNA methylation, potentially causing adverse effects on normal cellular function and gene expression.
Yes, mutations in the DNMT3B gene are linked to a rare genetic disorder called ICF (Immunodeficiency, Centromeric instability, Facial anomalies) syndrome, characterized by immune system deficiencies, facial abnormalities, and unstable centromeric regions in chromosomes.
Research has shown that alterations in DNMT3B expression or activity can be associated with various types of cancer, making it a potential biomarker for cancer diagnosis, prognosis, and treatment response.
DNMT3B plays a crucial role in establishing de novo DNA methylation patterns during embryonic development and cell differentiation, contributing to the epigenetic regulation of gene expression.
Inhibition of DNMT3B activity through targeted therapy or epigenetic modifying agents has been explored as a potential treatment strategy to reverse abnormal DNA methylation patterns and restore normal gene expression in cancer cells.
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