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FTL

  • Official Full Name

    ferritin, light polypeptide

  • Overview

    This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]
  • Synonyms

    FTL; ferritin, light polypeptide; LFTD; NBIA3; ferritin light chain; ferritin L-chain; ferritin L subunit; ferritin light polypeptide-like 3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Chicken
  • Horse
  • Human
  • Rat
  • Rhesus Macaque
  • E. coli
  • E.coli
  • HEK293
  • Human Liver
  • In Vitro Cell Free System
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • C
  • Myc
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FTL-529H Recombinant Human Ferritin, Light Polypeptide E.coli N/A
Human FTL-6939H Recombinant Human FTL protein(Met1-Asp175), His-tagged E. coli N-His Met1-Asp175
Human FTL-28154TH Recombinant Human FTL protein E.coli N/A
Human FTL-800H Recombinant Human FTL Protein, His-tagged E.coli His
Human FTL-65H Recombinant Human FTL protein, MYC/DDK-tagged HEK293 Myc/DDK
Human FTL-8235H Recombinant Human FTL protein, His & T7-tagged E.coli His/T7 Ser2~Asp175 (Accession # P02792)
Human FTL-6126HCL Recombinant Human FTL 293 Cell Lysate HEK293 N/A
Human FTL-26944TH Native Human FTL N/A
Human FTL-5123HF Recombinant Full Length Human FTL Protein, GST-tagged In Vitro Cell Free System GST 175 amino acids
Human FTL-3011H Recombinant Human RTL protein, GST-tagged E.coli GST Met1-Asp175
Human FTL-673H Native Human Ferritin, Light Polypeptide Human Liver N/A
Human FTL-2322H Recombinant Human FTL Protein (Ser2-Asp175), N-His tagged E.coli N-His Ser2-Asp175
Human FTL-4533H Recombinant Human FTL Protein, GST-tagged Wheat Germ GST
Human FTL-400H Recombinant Human FTL Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human FTL-9299HFL Recombinant Full Length Human FTL protein, Flag-tagged Mamanlian cells Flag
Rat FTL-2403R Recombinant Rat FTL Protein Mammalian Cell His
Rat FTL-2059R Recombinant Rat FTL Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat FTL-2059R-B Recombinant Rat FTL Protein Pre-coupled Magnetic Beads HEK293
Cattle FTL-8233C Recombinant Cattle FTL protein, His-tagged E.coli His Met1~Asp175 (Accession # O46415)
Horse FTL-8234H Recombinant Horse FTL protein, His-tagged E.coli His Met1~Asp175 (Accession # P02791)
Rhesus Macaque FTL-1758R Recombinant Rhesus monkey FTL Protein, His-tagged Mammalian Cell His
Rhesus Macaque FTL-1579R Recombinant Rhesus Macaque FTL Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque FTL-1579R-B Recombinant Rhesus Macaque FTL Protein Pre-coupled Magnetic Beads HEK293
Chicken FTL-5953C Recombinant Chicken FTL Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FTL Related Articles

FTL involved in several pathways and played different roles in them. We selected most pathways FTL participated on our site, such as Mineral absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with FTL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Mineral absorptionMT1B;SLC8A1;SLC11A1;VDR;MT1F;HEPH;SLC26A3;TRPM6;Trf

FTL has several biochemical functions, for example, ferric iron binding, identical protein binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FTL itself. We selected most functions FTL had, and list some proteins which have the same functions with FTL. You can find most of the proteins on our site.

Function Related Protein
ferric iron bindingFTH1A;Trf;FTL;FTH1;FTH1B;MIOX;FTMT;TF;FTHL17
identical protein bindingRIPK1;APLP1;LYZ1;RNF4;TMEM115;DHX8;CHEK2;FBP1;ZHX2
iron ion bindingHIF1AN;CYP4A11;TYW1B;CH25HL2;PDF;FDX1;JHDM1D;CYP51A1;CYP2C55
protein bindingPDZD11;FGD5;TRIP6;PSMB8;TESC;POLM;CALM2;RBBP4;ZNF544

FTL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FTL here. Most of them are supplied by our site. Hope this information will be useful for your research of FTL.

FTH1; SDCBP

Jeon, JO; Kim, S; et al. Designed Nanocage Displaying Ligand-Specific Peptide Bunches for High Affinity and Biological Activity. ACS NANO 7:7462-7471(2013).
Mahawar, M; Rabadi, SM; et al. Identification of a Live Attenuated Vaccine Candidate for Tularemia Prophylaxis. PLOS ONE 8:-(2013).
  • Q&As
  • Reviews

Q&As (6)

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What is the relationship between FTL protein and Alzheimer's disease? 12/28/2022

Current studies have shown that abnormal iron metabolism may be related to Alzheimer's disease, and FTL protein is one of the key proteins in iron metabolism. Therefore, FTL protein may be involved in the occurrence and progression of Alzheimer's disease. However, further research is needed to confirm the specific relationship.

What health problems can abnormal FTL protein levels cause? 03/24/2022

Abnormal levels of FTL protein can lead to a variety of health problems such as abnormal iron metabolism, anemia, neuropathy, heart disease, immune system abnormalities, and diabetes.

How can FTL proteins be used to treat certain diseases? 02/08/2022

Research is currently underway to develop new therapeutics using FTL protein as a target, such as improving symptoms of abnormal iron metabolism and related diseases by modulating the expression and function of FTL protein. However, further research and clinical trial validation are needed for specific applications.

How to Prevent FTL Protein-Related Diseases? 01/10/2022

Prevention of FTL protein-related diseases is mainly by maintaining a healthy lifestyle, such as a balanced diet, moderate exercise, and avoiding excessive intake of iron-containing drugs. In addition, regular check-ups and related examinations can also help to detect potential problems early.

What is the relationship between FTL protein and multiple sclerosis? 11/30/2021

Current studies have shown that multiple sclerosis may be related to abnormal iron metabolism, and FTL protein is one of the key proteins in iron metabolism, so it may be related to the occurrence and progression of multiple sclerosis. However, further research is needed to confirm the specific relationship.

How can lifestyle changes affect the function of FTL proteins? 12/21/2019

Lifestyle changes, such as healthy diet and moderate exercise, can affect the function and expression level of FTL protein. These changes can promote normal iron metabolism, which can help maintain good health.

Customer Reviews (3)

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Reviews
12/03/2022

    FTL has very good antigenicity and can induce target immune response.

    07/02/2022

      FTL has high sensitivity and strong specificity.

      05/16/2021

        The catalytic efficiency is high and the time consuming is short, which greatly saves the time of the experimental members.

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