FTL
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Official Full Name
ferritin, light polypeptide
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Overview
This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008] -
Synonyms
FTL; ferritin, light polypeptide; LFTD; NBIA3; ferritin light chain; ferritin L-chain; ferritin L subunit; ferritin light polypeptide-like 3;
- Recombinant Proteins
- Cell & Tissue Lysates
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Cattle
- Chicken
- Horse
- Human
- Rat
- Rhesus Macaque
- E. coli
- E.coli
- HEK293
- Human Liver
- In Vitro Cell Free System
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- C
- Myc
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- His|T7
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- FTL Related Articles
FTL involved in several pathways and played different roles in them. We selected most pathways FTL participated on our site, such as Mineral absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with FTL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Mineral absorption | MT1B;SLC8A1;SLC11A1;VDR;MT1F;HEPH;SLC26A3;TRPM6;Trf |
FTL has several biochemical functions, for example, ferric iron binding, identical protein binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FTL itself. We selected most functions FTL had, and list some proteins which have the same functions with FTL. You can find most of the proteins on our site.
Function | Related Protein |
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ferric iron binding | FTH1A;Trf;FTL;FTH1;FTH1B;MIOX;FTMT;TF;FTHL17 |
identical protein binding | RIPK1;APLP1;LYZ1;RNF4;TMEM115;DHX8;CHEK2;FBP1;ZHX2 |
iron ion binding | HIF1AN;CYP4A11;TYW1B;CH25HL2;PDF;FDX1;JHDM1D;CYP51A1;CYP2C55 |
protein binding | PDZD11;FGD5;TRIP6;PSMB8;TESC;POLM;CALM2;RBBP4;ZNF544 |
FTL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FTL here. Most of them are supplied by our site. Hope this information will be useful for your research of FTL.
FTH1; SDCBP
- Q&As
- Reviews
Q&As (6)
Ask a questionCurrent studies have shown that abnormal iron metabolism may be related to Alzheimer's disease, and FTL protein is one of the key proteins in iron metabolism. Therefore, FTL protein may be involved in the occurrence and progression of Alzheimer's disease. However, further research is needed to confirm the specific relationship.
Abnormal levels of FTL protein can lead to a variety of health problems such as abnormal iron metabolism, anemia, neuropathy, heart disease, immune system abnormalities, and diabetes.
Research is currently underway to develop new therapeutics using FTL protein as a target, such as improving symptoms of abnormal iron metabolism and related diseases by modulating the expression and function of FTL protein. However, further research and clinical trial validation are needed for specific applications.
Prevention of FTL protein-related diseases is mainly by maintaining a healthy lifestyle, such as a balanced diet, moderate exercise, and avoiding excessive intake of iron-containing drugs. In addition, regular check-ups and related examinations can also help to detect potential problems early.
Current studies have shown that multiple sclerosis may be related to abnormal iron metabolism, and FTL protein is one of the key proteins in iron metabolism, so it may be related to the occurrence and progression of multiple sclerosis. However, further research is needed to confirm the specific relationship.
Lifestyle changes, such as healthy diet and moderate exercise, can affect the function and expression level of FTL protein. These changes can promote normal iron metabolism, which can help maintain good health.
Customer Reviews (3)
Write a reviewFTL has very good antigenicity and can induce target immune response.
FTL has high sensitivity and strong specificity.
The catalytic efficiency is high and the time consuming is short, which greatly saves the time of the experimental members.
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